Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome

Genomic analysis of hepatocellular carcinoma (HCC) has been shown to provide clues about local risk factors. In the last decades, the mortality from malignant liver tumors increased sharply in Romania, where both hepatitis viruses and environmental pollutants are known to be highly prevalent. To dat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of exposure science & environmental epidemiology 2015-05, Vol.25 (3), p.256-263
Hauptverfasser:	Tanase, Anna-Maria, Marchio, Agnès, Dumitrascu, Traian, Dima, Simona, Herlea, Vlad, Oprisan, Gabriela, Dejean, Anne, Popescu, Irinel, Pineau, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 692/699/67/1504/1610 692/699/67/2324 704/172 Adult Aflatoxin B1 Aflatoxins Aged Analysis Biochemistry, Molecular Biology Biomarkers, Tumor - genetics Cancer Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - genetics Chemical mutagenesis Deoxyribonucleic acid DNA DNA, Mitochondrial - drug effects Environmental aspects Environmental Exposure - adverse effects Environmental factors Environmental Pollutants - toxicity Epidemiology Female Gene expression Gene mutations Genes Genetic aspects Genetic Markers Genomic analysis Genomics Hepatitis Hepatocellular carcinoma Hepatoma Human health and pathology Humans Hépatology and Gastroenterology Life Sciences Liver cancer Liver Neoplasms - chemically induced Liver Neoplasms - genetics Male Medicine Medicine & Public Health Middle Aged Mitochondria Mortality Mutation NRF2 protein Oncology, Experimental original-article Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics p53 Protein Point Mutation - drug effects Pollutants Prospective Studies Risk analysis Risk Factors Romania Tumors Western Europe β-Catenin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!