APOBEC3A intratumoral DNA electroporation in mice

Human APOBEC3A (A3A) cytidine deaminase shows pro-apoptotic properties resulting from hypermutation of genomic DNA, induction of double-stranded DNA breaks (DSBs) and G1 cell cycle arrest. Given this, we evaluated the antitumor efficacy of A3A by intratumoral electroporation of an A3A expression pla...

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Veröffentlicht in:	Gene therapy 2017-02, Vol.24 (2), p.74-83
Hauptverfasser:	Kostrzak, A, Caval, V, Escande, M, Pliquet, E, Thalmensi, J, Bestetti, T, Julithe, M, Fiette, L, Huet, T, Wain-Hobson, S, Langlade-Demoyen, P
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 45/77 59/5 631/1647/1407 631/1647/1511 631/45/607/1164 631/67/1059 631/67/1813/1634 64/60 Analysis Animals Antitumor activity Apolipoproteins Apoptosis Biochemistry, Molecular Biology Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment Cell Biology Cell cycle Cytidine deaminase Cytidine Deaminase - genetics Deoxyribonucleic acid Diagnosis DNA DNA damage Drb1 protein Electroporation Electroporation - methods Female Fibrosarcoma Gene Expression Gene mutation Gene Therapy Genes Genetic engineering Genetic Therapy Histocompatibility antigens HLA histocompatibility antigens Human Genetics Life Sciences Lymphocytes, Tumor-Infiltrating - immunology Male Melanoma Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - therapy Methods Mice Mice, Inbred C57BL Molecular biology Mutation Nanotechnology original-article Plasmids - genetics Proteins - genetics Risk factors Testing Transgenic mice Tumor Cells, Cultured Tumors
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