The protofilament architecture of a de novo designed coiled coil-based amyloidogenic peptide

Amyloid fibrils are polymers formed by proteins under specific conditions and in many cases they are related to pathogenesis, such as Parkinson’s and Alzheimer’s diseases. Their hallmark is the presence of a β-sheet structure. High resolution structural data on these systems as well as information g...

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Veröffentlicht in:	Journal of structural biology 2018-09, Vol.203 (3), p.263-272
Hauptverfasser:	de Freitas, Mônica Santos, Rezaei Araghi, Raheleh, Brandenburg, Enrico, Leiterer, Jork, Emmerling, Franziska, Folmert, Kristin, Gerling-Driessen, Ulla I.M., Bardiaux, Benjamin, Böttcher, Christoph, Pagel, Kevin, Diehl, Anne, Berlepsch, Hans v., Oschkinat, Hartmut, Koksch, Beate
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Amino Acid Sequence Amyloid Amyloid fibrils Amyloidogenic Proteins Cryoelectron Microscopy Electron microscopy Humans Life Sciences Microscopy, Atomic Force Nuclear Magnetic Resonance, Biomolecular Peptides Protein Domains Protein Structure, Secondary
Online-Zugang:	Volltext
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