Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

Eukaryotic DNA polymerase of the polX family, such as pol μ and terminal deoxynucleotidyl transferase (TdT), are key components of the non-homologous end-joining or V(D)J recombination machinery, respectively. The established role of TdT is to add random nucleotides during V(D)J recombination. Here...

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Veröffentlicht in:	Structure (London) 2016-09, Vol.24 (9), p.1452-1463
Hauptverfasser:	Loc'h, Jérôme, Rosario, Sandrine, Delarue, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Binding Sites Biochemistry, Molecular Biology Chemical Sciences Cristallography Crystallography, X-Ray DNA DNA - chemistry DNA - genetics DNA - metabolism DNA Nucleotidylexotransferase DNA Nucleotidylexotransferase - chemistry DNA Nucleotidylexotransferase - genetics DNA Nucleotidylexotransferase - metabolism DNA-Directed DNA Polymerase DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism double-strand-break DNA repair Gene Expression Humans Life Sciences micro-homology base pair Models, Molecular Nucleotides Nucleotides - chemistry Nucleotides - metabolism Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Recombinant Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Substrate Specificity V(D)J Recombination X-ray crystallography
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