αvβ5/β6 integrin suppression leads to a stimulation of α2β1 dependent cell migration resistant to PI3K/Akt inhibition

Crosstalk between integrins is involved in the regulation of various cell functions including cell migration. Here we identify the interplay between the integrins αvβ5/β6 and α2β1 during cell migration toward type I collagen. Human colon cancer cell lines HT29-D4 and SW480 were used as cell models....

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Veröffentlicht in:	Experimental cell research 2009-07, Vol.315 (11), p.1840-1849
Hauptverfasser:	Defilles, Céline, Lissitzky, Jean-Claude, Montero, Marie-Pierre, André, Frédéric, Prévot, Charles, Delamarre, Estelle, Marrakchi, Naziha, Luis, José, Rigot, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm/genetics Antigens, Neoplasm/physiology Cell Line, Tumor Cell migration Cell Movement/drug effects Cell Movement/physiology Collagen Type I/metabolism Colon adenocarcinoma Crosstalk Focal Adhesions Humans Integrin alpha2beta1/antagonists & inhibitors Integrin alpha2beta1/genetics Integrin alpha2beta1/physiology Integrin signaling Integrins Integrins/antagonists & inhibitors Integrins/genetics Integrins/physiology Life Sciences Oncogene Protein v-akt/antagonists & inhibitors Oncogene Protein v-akt/genetics Oncogene Protein v-akt/physiology Phosphatidylinositol 3-Kinases/antagonists & inhibitors Phosphatidylinositol 3-Kinases/physiology PI3K PKC Protein Kinase Inhibitors/pharmacology Receptors, Vitronectin/antagonists & inhibitors Receptors, Vitronectin/genetics Receptors, Vitronectin/physiology RNA, Small Interfering/genetics Signal Transduction
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