Natural noncanonical protein splicing yields products with diverse b-amino acid residues

Current textbook knowledge holds that the structural scope of ribosomal biosynthesis is based exclusively on a-amino acid backbone topology. Here we report the genome-guided discovery of bacterial pathways that posttranslationally create b-amino acid-containing products. The transformation is widesp...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-02, Vol.359 (6377), p.779-782
Hauptverfasser:	Morinaka, Brandon I, Lakis, Edgars, Verest, Marjan, Helf, Maximilian J, Scalvenzi, Thibault, Vagstad, Anna L, Sims, James, Sunagawa, Shinichi, Gugger, Muriel, Piel, Jörn
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Amino Acid Sequence Amino Acids Bacterial Proteins Cyanobacteria Escherichia coli Genetic Loci Life Sciences Microbiology and Parasitology Mutation Protein Processing, Post-Translational Protein Splicing Tyramine
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