Terminal Deoxynucleotidyl Transferase in the Synthesis and Modification of Nucleic Acids

The terminal deoxynucleotidyl transferase (TdT) belongs to the X family of DNA polymerases. This unusual polymerase catalyzes the template‐independent addition of random nucleotides on 3′‐overhangs during V(D)J recombination. The biological function and intrinsic biochemical properties of the TdT ha...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2019-04, Vol.20 (7), p.860-871
Hauptverfasser:	Sarac, Ivo, Hollenstein, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization Base Pairing Chemical Sciences Deoxyribonucleic acid DNA DNA nucleotidylexotransferase DNA Nucleotidylexotransferase - chemistry DNA, Single-Stranded - chemical synthesis DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-directed DNA polymerase DNA-Directed DNA Polymerase - chemistry end labeling HeLa Cells Humans immobilization Metals - metabolism Nucleic acids Nucleoside triphosphates Nucleotides Nucleotides - chemistry Oligonucleotides Oligonucleotides - chemical synthesis Organic chemistry Saccharomyces cerevisiae terminal deoxynucleotidyl transferase V(D)J recombination
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