A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully establis...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2018-10, Vol.49 (4), p.654-665.e5
Hauptverfasser:	Postat, Jérémy, Olekhnovitch, Romain, Lemaître, Fabrice, Bousso, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial agents Cells, Cultured Cellular manufacture Chemokines Cytokines Cytokines - immunology Cytokines - metabolism Experiments HEK293 Cells Host-Parasite Interactions - immunology Humans Immune system Immunology Infections Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - parasitology Inflammatory response Leishmania Leishmania major - immunology Leishmania major - physiology Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - metabolism Leishmaniasis, Cutaneous - parasitology Life Sciences Macrophages - immunology Macrophages - metabolism Macrophages - parasitology Metabolism Mice, Inbred C57BL Mice, Transgenic monocyte-derived cells Monocytes Monocytes - immunology Monocytes - metabolism Monocytes - parasitology Neutrophils Nitric oxide Nitric Oxide - immunology Nitric Oxide - metabolism OXPHOS quorum sensing Quorum Sensing - immunology Respiration Rodents Software
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