Characterization of botulinum neurotoxin type A subtypes by immunocapture enrichment and liquid chromatography–tandem mass spectrometry

Botulinum neurotoxins (BoNT) are divided into seven toxinotypes based on their immunological properties and each toxinotype contains several subtypes according to their amino acid sequences. Here, we designed a mass spectrometry method able to identify BoNT/A subtypes in complex matrices including c...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2015-07, Vol.407 (19), p.5559-5570
Hauptverfasser:	Morineaux, Valérie, Mazuet, Christelle, Hilaire, Didier, Enche, Julien, Popoff, Michel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acid sequences Amino acids Analysis Analytical Chemistry Animals antibodies Biochemistry blood serum botulinum toxin Botulinum Toxins, Type A - chemistry Botulism Chains Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Chromatography Chromatography, Liquid - methods Citrus Culture detection limit Drinking water Enrichment Female Food Food Contamination Food Science Immunology Laboratory Medicine Life Sciences Limit of Detection Liquid chromatography Liquids Mass spectrometry Mice Mice, Inbred BALB C Molecular Sequence Data monitoring Monitoring/Environmental Analysis Monoclonal antibodies Neurotoxic agents Neurotoxins orange juice Paper in Forefront Peptides Scientific imaging spectrometers tandem mass spectrometry Tandem Mass Spectrometry - methods tap water Thyroid Toxicology Toxins
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