Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate

•Stable Jurkat cell line expressing AID-His130Pro was established.•Mutagenic activity of AID-His130Pro mutant was assessed on an artificial substrate.•AID-His130Pro retained a significant mutagenic activity.•The His130 residue is located in a region required for CSR but not for SHM. Activation induc...

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Veröffentlicht in:	Molecular immunology 2016-11, Vol.79, p.77-82
Hauptverfasser:	Ouadani, Hanen, Ben-Mustapha, Imen, Ben-ali, Meriem, Larguèche, Beya, Jovanic, Tihana, Garcia, Sylvie, Arcangioli, Benoit, Elloumi-Zghal, Houda, Fathallah, Dahmani, Hachicha, Mongia, Masmoudi, Hatem, Rougeon, François, Barbouche, Mohamed-Ridha
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation induced cytidine deaminase AID mutagenic activity Blotting, Western Class switch recombination Cofactors Cytidine Deaminase Cytidine Deaminase - genetics Humans Hyper IgM 2 Hyper-IgM Immunodeficiency Syndrome Hyper-IgM Immunodeficiency Syndrome - genetics Immunoglobulin Class Switching Immunoglobulin Class Switching - genetics Jurkat Cells Life Sciences Mutagenesis, Site-Directed Mutation Somatic hypermutation Somatic Hypermutation, Immunoglobulin Somatic Hypermutation, Immunoglobulin - genetics
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