impact of smoking and polymorphic enzymes of xenobiotic metabolism on the stage of bladder tumors: a generalized ordered logistic regression analysis

Cigarette smoking is the predominant risk factor for bladder cancer in males and females. The tobacco carcinogens are metabolized by various xenobiotic metabolizing enzymes such as N-acetyltransferases (NAT) and glutathione S-transferases (GST). Polymorphisms in NAT and GST genes alter the ability o...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2010-07, Vol.136 (7), p.1111-1116
Hauptverfasser:	Khedhiri, Sami, Stambouli, Nejla, Ouerhani, Slah, Rouissi, Kamel, Marrakchi, Raja, Gaaied, Amel B, Slama, M. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - metabolism Biological and medical sciences Bladder Bladder cancer Cancer Cancer Research Case-Control Studies Disease Progression Female Genotype Glutathione Transferase - genetics Glutathione Transferase - metabolism Hematology Human health and pathology Humans Internal Medicine Life Sciences Logistic Models Male Medical sciences Medicine Medicine & Public Health Neoplasm Staging Nephrology. Urinary tract diseases Oncology Original Paper Pharmacology. Drug treatments Polymorphism, Genetic - genetics Risk Factors Smoking Smoking - adverse effects Tobacco, tobacco smoking Toxicology Tumors of the urinary system Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urology and Nephrology Xenobiotic metabolism
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