Actin’ on HIV: How Dendritic Cells Spread Infection
Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for effic...
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| Veröffentlicht in: | Cell host & microbe 2016-03, Vol.19 (3), p.267-269 |
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| creator | Donahue, Daniel A. Schwartz, Olivier |
| description | Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.
Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer. |
| doi_str_mv | 10.1016/j.chom.2016.02.016 |
| format | Article |
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Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.</description><identifier>ISSN: 1931-3128</identifier><identifier>EISSN: 1934-6069</identifier><identifier>DOI: 10.1016/j.chom.2016.02.016</identifier><identifier>PMID: 26962935</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Actins - metabolism ; Cellular Biology ; Dendritic Cells - immunology ; HIV Infections - immunology ; HIV-1 - physiology ; Human health and pathology ; Humans ; Infectious diseases ; Life Sciences ; T-Lymphocytes - immunology</subject><ispartof>Cell host & microbe, 2016-03, Vol.19 (3), p.267-269</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f03ceeeebbca1769cccb49e078b7cc8d9fc4dcec40f81149c8b73e5e2a23e84f3</citedby><cites>FETCH-LOGICAL-c438t-f03ceeeebbca1769cccb49e078b7cc8d9fc4dcec40f81149c8b73e5e2a23e84f3</cites><orcidid>0000-0002-0729-1475</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chom.2016.02.016$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26962935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://pasteur.hal.science/pasteur-01372388$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Donahue, Daniel A.</creatorcontrib><creatorcontrib>Schwartz, Olivier</creatorcontrib><title>Actin’ on HIV: How Dendritic Cells Spread Infection</title><title>Cell host & microbe</title><addtitle>Cell Host Microbe</addtitle><description>Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.
Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.</description><subject>Actins - metabolism</subject><subject>Cellular Biology</subject><subject>Dendritic Cells - immunology</subject><subject>HIV Infections - immunology</subject><subject>HIV-1 - physiology</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>T-Lymphocytes - immunology</subject><issn>1931-3128</issn><issn>1934-6069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi0EomV5AQ4oRy4JXrI4iEtVllSqxIHlajmTiXDVxsVOi7jxGrweT4JLgSNzmdHom9_yR8gJowmjLD-fJfBsFwkPc0J5EtoOGbJSpHFO83L3e2axYFwOyIH3M0qzjBZsnwx4Xua8FNmQZCPoTff5_hHZLqomTxdRZV-jK-waZ3oD0Rjncx_dLx3qJpp0LQbcdkdkr9Vzj8c__ZA83lw_jKt4enc7GY-mMaRC9nFLBWCougbNirwEgDotkRayLgBkU7aQNoCQ0lYylpYQ9gIz5JoLlGkrDkm8zX3Wc7V0ZqHdm7LaqGo0VUvte1w5RZkouJByzQJ_tuWXzr6s0PdqYTyEL-gO7corVhRcCpEKHlC-RcFZ7x22f_mMqo1eNVMbvWqjV1EensnD0elP_qpeYPN38uszAJdbAIOVtUGnPBjsABvjgjrVWPNf_helyItG</recordid><startdate>20160309</startdate><enddate>20160309</enddate><creator>Donahue, Daniel A.</creator><creator>Schwartz, Olivier</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0729-1475</orcidid></search><sort><creationdate>20160309</creationdate><title>Actin’ on HIV: How Dendritic Cells Spread Infection</title><author>Donahue, Daniel A. ; Schwartz, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f03ceeeebbca1769cccb49e078b7cc8d9fc4dcec40f81149c8b73e5e2a23e84f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Actins - metabolism</topic><topic>Cellular Biology</topic><topic>Dendritic Cells - immunology</topic><topic>HIV Infections - immunology</topic><topic>HIV-1 - physiology</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donahue, Daniel A.</creatorcontrib><creatorcontrib>Schwartz, Olivier</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Cell host & microbe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donahue, Daniel A.</au><au>Schwartz, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Actin’ on HIV: How Dendritic Cells Spread Infection</atitle><jtitle>Cell host & microbe</jtitle><addtitle>Cell Host Microbe</addtitle><date>2016-03-09</date><risdate>2016</risdate><volume>19</volume><issue>3</issue><spage>267</spage><epage>269</epage><pages>267-269</pages><issn>1931-3128</issn><eissn>1934-6069</eissn><abstract>Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.
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| ispartof | Cell host & microbe, 2016-03, Vol.19 (3), p.267-269 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | Actins - metabolism Cellular Biology Dendritic Cells - immunology HIV Infections - immunology HIV-1 - physiology Human health and pathology Humans Infectious diseases Life Sciences T-Lymphocytes - immunology |
| title | Actin’ on HIV: How Dendritic Cells Spread Infection |
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