An epidemiological study of dengue in Delhi, India
[Display omitted] •Targeting the index cases in different socio-economic groups of a community to evaluate the prospective dengue cases for proactive readiness of a resource limited health infrastructure.•Inclusion of asymptomatic dengue cases to ascertain the true burden of the disease load for bet...
Gespeichert in:
| Veröffentlicht in: | Acta tropica 2016-01, Vol.153, p.21-27 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 27 |
|---|---|
| container_issue | |
| container_start_page | 21 |
| container_title | Acta tropica |
| container_volume | 153 |
| creator | Vikram, Kumar Nagpal, B.N Pande, Veena Srivastava, Aruna Saxena, Rekha Anvikar, Anup Das, Aparup Singh, Himmat Anushrita Gupta, Sanjeev K. Tuli, N.R. Telle, Olivier Yadav, N.K. Valecha, Neena Paul, Richard |
| description | [Display omitted]
•Targeting the index cases in different socio-economic groups of a community to evaluate the prospective dengue cases for proactive readiness of a resource limited health infrastructure.•Inclusion of asymptomatic dengue cases to ascertain the true burden of the disease load for better prevention and control.•Assessing the rate of secondary infections in a community for a possible prevention of developing Dengue Haemorrhagic Fever/ Dengue Shock Syndrome.
Delhi, the capital of India, is an important metropolitan hub for major financial and sociocultural exchanges, offering challenging threats to current public health infrastructure. In recent past, an upsurge of dengue cases in Delhi posed a significant menace to the existing dengue control policies. To reform the control strategies and take timely intervention to prevent future epidemics, an epidemiological study on the proportion of both asymptomatic and symptomatic dengue infections in selected population was conducted. The aim of the study was to investigate and assess the epidemiology of dengue infection and to estimate the proportion of asymptomatic and symptomatic dengue infections in Delhi. In this study, around 50 confirmed dengue cases, a total of 2125 individuals as household and neighbourhood contacts, with or without dengue febrile illness, were finger pricked and serologically detected as dengue positive or negative using SD Duo Bioline Rapid Diagnostic Test (SD Inc, Korea) with NS1, IgM & IgG combo test, which detected dengue virus antigen and antibodies to dengue virus in human blood. Out of 2125 individuals, 768 (36.1%) individuals showed positive dengue test with past (25.5%), primary (1.88%) or secondary (8.8%) dengue infections. Higher percentage of IgG was found in age groups 15–24 years and 25–50 years (36% each). Infants ( |
| doi_str_mv | 10.1016/j.actatropica.2015.09.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_pasteur_01370785v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0001706X15301169</els_id><sourcerecordid>1735903616</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-2085ea9ac26c9e9f0e445cd10dcf1c9d7a1ee066cc87bebb905aa07ef430970b3</originalsourceid><addsrcrecordid>eNqNkEtLxDAUhYMoOj7-gtSdC1tv0iaZLIfxCQNuFNyFNLnVDJ2mJq3gv7cyKi5dXS585xz4CDmjUFCg4nJdGDuYIYbeW1MwoLwAVQDjO2RG57LMBePVLpkBAM0liOcDcpjSevqY5GyfHDBRlSVIMSNs0WXYe4cbH9rwMvW1WRpG95GFJnPYvYyY-S67wvbVX2T3nfPmmOw1pk148n2PyNPN9ePyLl893N4vF6vcVpQPOYM5R6OMZcIqVA1gVXHrKDjbUKucNBQRhLB2LmusawXcGJDYVCUoCXV5RPJt76tpdR_9xsQPHYzXd4uV7k0acIwaaClBzvk7nfjzLd_H8DZiGvTGJ4ttazoMY9JUllxBKaiYULVFbQwpRWx--ynoL8V6rf8o1l-KNSg9KZ6yp98zY71B95v8cToByy2Ak5x3j1En67Gz6HxEO2gX_D9mPgECSZHK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1735903616</pqid></control><display><type>article</type><title>An epidemiological study of dengue in Delhi, India</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Vikram, Kumar ; Nagpal, B.N ; Pande, Veena ; Srivastava, Aruna ; Saxena, Rekha ; Anvikar, Anup ; Das, Aparup ; Singh, Himmat ; Anushrita ; Gupta, Sanjeev K. ; Tuli, N.R. ; Telle, Olivier ; Yadav, N.K. ; Valecha, Neena ; Paul, Richard</creator><creatorcontrib>Vikram, Kumar ; Nagpal, B.N ; Pande, Veena ; Srivastava, Aruna ; Saxena, Rekha ; Anvikar, Anup ; Das, Aparup ; Singh, Himmat ; Anushrita ; Gupta, Sanjeev K. ; Tuli, N.R. ; Telle, Olivier ; Yadav, N.K. ; Valecha, Neena ; Paul, Richard</creatorcontrib><description>[Display omitted]
•Targeting the index cases in different socio-economic groups of a community to evaluate the prospective dengue cases for proactive readiness of a resource limited health infrastructure.•Inclusion of asymptomatic dengue cases to ascertain the true burden of the disease load for better prevention and control.•Assessing the rate of secondary infections in a community for a possible prevention of developing Dengue Haemorrhagic Fever/ Dengue Shock Syndrome.
Delhi, the capital of India, is an important metropolitan hub for major financial and sociocultural exchanges, offering challenging threats to current public health infrastructure. In recent past, an upsurge of dengue cases in Delhi posed a significant menace to the existing dengue control policies. To reform the control strategies and take timely intervention to prevent future epidemics, an epidemiological study on the proportion of both asymptomatic and symptomatic dengue infections in selected population was conducted. The aim of the study was to investigate and assess the epidemiology of dengue infection and to estimate the proportion of asymptomatic and symptomatic dengue infections in Delhi. In this study, around 50 confirmed dengue cases, a total of 2125 individuals as household and neighbourhood contacts, with or without dengue febrile illness, were finger pricked and serologically detected as dengue positive or negative using SD Duo Bioline Rapid Diagnostic Test (SD Inc, Korea) with NS1, IgM & IgG combo test, which detected dengue virus antigen and antibodies to dengue virus in human blood. Out of 2125 individuals, 768 (36.1%) individuals showed positive dengue test with past (25.5%), primary (1.88%) or secondary (8.8%) dengue infections. Higher percentage of IgG was found in age groups 15–24 years and 25–50 years (36% each). Infants (<1 year) presented higher incidence of new infections (22% of NS1+IgM positives) as compared to adults. Further analysis revealed that out of the 226 newly infected cases (including NS1 and IgM positives), 142 (63%) were asymptomatic and 84 (37%) were symptomatic, as per WHO guidelines. Our findings also suggest that out of the total population screened, 10.6% dengue infection was either primary or secondary. On the basis of these results, it may be hypothesized that there are large number of asymptomatic dengue infections in the community as compared to reported symptomatic cases in Delhi. For the effective control of dengue transmission in such community like Delhi where dengue epidemics have frequently been encountered, it is essential to ascertain the proportion of asymptomatic dengue infections which may act as a reservoir for dengue transmission, as well as threat for developing dengue haemorrhagic fever (DHF).</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2015.09.025</identifier><identifier>PMID: 26433076</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asymptomatic infection ; Child ; Child, Preschool ; Dengue ; Dengue - epidemiology ; Dengue Virus - isolation & purification ; Emerging diseases ; Epidemiologic Studies ; Female ; Human health and pathology ; Humans ; Incidence ; Index case ; India - epidemiology ; Infant ; Life Sciences ; Male ; Mass Screening - statistics & numerical data ; Middle Aged ; Primary dengue infection ; Secondary dengue infection ; Young Adult</subject><ispartof>Acta tropica, 2016-01, Vol.153, p.21-27</ispartof><rights>2015</rights><rights>Copyright © 2015. Published by Elsevier B.V.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-2085ea9ac26c9e9f0e445cd10dcf1c9d7a1ee066cc87bebb905aa07ef430970b3</citedby><cites>FETCH-LOGICAL-c415t-2085ea9ac26c9e9f0e445cd10dcf1c9d7a1ee066cc87bebb905aa07ef430970b3</cites><orcidid>0000-0002-9473-8406 ; 0000-0002-0665-5089</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actatropica.2015.09.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26433076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://pasteur.hal.science/pasteur-01370785$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vikram, Kumar</creatorcontrib><creatorcontrib>Nagpal, B.N</creatorcontrib><creatorcontrib>Pande, Veena</creatorcontrib><creatorcontrib>Srivastava, Aruna</creatorcontrib><creatorcontrib>Saxena, Rekha</creatorcontrib><creatorcontrib>Anvikar, Anup</creatorcontrib><creatorcontrib>Das, Aparup</creatorcontrib><creatorcontrib>Singh, Himmat</creatorcontrib><creatorcontrib>Anushrita</creatorcontrib><creatorcontrib>Gupta, Sanjeev K.</creatorcontrib><creatorcontrib>Tuli, N.R.</creatorcontrib><creatorcontrib>Telle, Olivier</creatorcontrib><creatorcontrib>Yadav, N.K.</creatorcontrib><creatorcontrib>Valecha, Neena</creatorcontrib><creatorcontrib>Paul, Richard</creatorcontrib><title>An epidemiological study of dengue in Delhi, India</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>[Display omitted]
•Targeting the index cases in different socio-economic groups of a community to evaluate the prospective dengue cases for proactive readiness of a resource limited health infrastructure.•Inclusion of asymptomatic dengue cases to ascertain the true burden of the disease load for better prevention and control.•Assessing the rate of secondary infections in a community for a possible prevention of developing Dengue Haemorrhagic Fever/ Dengue Shock Syndrome.
Delhi, the capital of India, is an important metropolitan hub for major financial and sociocultural exchanges, offering challenging threats to current public health infrastructure. In recent past, an upsurge of dengue cases in Delhi posed a significant menace to the existing dengue control policies. To reform the control strategies and take timely intervention to prevent future epidemics, an epidemiological study on the proportion of both asymptomatic and symptomatic dengue infections in selected population was conducted. The aim of the study was to investigate and assess the epidemiology of dengue infection and to estimate the proportion of asymptomatic and symptomatic dengue infections in Delhi. In this study, around 50 confirmed dengue cases, a total of 2125 individuals as household and neighbourhood contacts, with or without dengue febrile illness, were finger pricked and serologically detected as dengue positive or negative using SD Duo Bioline Rapid Diagnostic Test (SD Inc, Korea) with NS1, IgM & IgG combo test, which detected dengue virus antigen and antibodies to dengue virus in human blood. Out of 2125 individuals, 768 (36.1%) individuals showed positive dengue test with past (25.5%), primary (1.88%) or secondary (8.8%) dengue infections. Higher percentage of IgG was found in age groups 15–24 years and 25–50 years (36% each). Infants (<1 year) presented higher incidence of new infections (22% of NS1+IgM positives) as compared to adults. Further analysis revealed that out of the 226 newly infected cases (including NS1 and IgM positives), 142 (63%) were asymptomatic and 84 (37%) were symptomatic, as per WHO guidelines. Our findings also suggest that out of the total population screened, 10.6% dengue infection was either primary or secondary. On the basis of these results, it may be hypothesized that there are large number of asymptomatic dengue infections in the community as compared to reported symptomatic cases in Delhi. For the effective control of dengue transmission in such community like Delhi where dengue epidemics have frequently been encountered, it is essential to ascertain the proportion of asymptomatic dengue infections which may act as a reservoir for dengue transmission, as well as threat for developing dengue haemorrhagic fever (DHF).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asymptomatic infection</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dengue</subject><subject>Dengue - epidemiology</subject><subject>Dengue Virus - isolation & purification</subject><subject>Emerging diseases</subject><subject>Epidemiologic Studies</subject><subject>Female</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Index case</subject><subject>India - epidemiology</subject><subject>Infant</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mass Screening - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Primary dengue infection</subject><subject>Secondary dengue infection</subject><subject>Young Adult</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLxDAUhYMoOj7-gtSdC1tv0iaZLIfxCQNuFNyFNLnVDJ2mJq3gv7cyKi5dXS585xz4CDmjUFCg4nJdGDuYIYbeW1MwoLwAVQDjO2RG57LMBePVLpkBAM0liOcDcpjSevqY5GyfHDBRlSVIMSNs0WXYe4cbH9rwMvW1WRpG95GFJnPYvYyY-S67wvbVX2T3nfPmmOw1pk148n2PyNPN9ePyLl893N4vF6vcVpQPOYM5R6OMZcIqVA1gVXHrKDjbUKucNBQRhLB2LmusawXcGJDYVCUoCXV5RPJt76tpdR_9xsQPHYzXd4uV7k0acIwaaClBzvk7nfjzLd_H8DZiGvTGJ4ttazoMY9JUllxBKaiYULVFbQwpRWx--ynoL8V6rf8o1l-KNSg9KZ6yp98zY71B95v8cToByy2Ak5x3j1En67Gz6HxEO2gX_D9mPgECSZHK</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Vikram, Kumar</creator><creator>Nagpal, B.N</creator><creator>Pande, Veena</creator><creator>Srivastava, Aruna</creator><creator>Saxena, Rekha</creator><creator>Anvikar, Anup</creator><creator>Das, Aparup</creator><creator>Singh, Himmat</creator><creator>Anushrita</creator><creator>Gupta, Sanjeev K.</creator><creator>Tuli, N.R.</creator><creator>Telle, Olivier</creator><creator>Yadav, N.K.</creator><creator>Valecha, Neena</creator><creator>Paul, Richard</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9473-8406</orcidid><orcidid>https://orcid.org/0000-0002-0665-5089</orcidid></search><sort><creationdate>201601</creationdate><title>An epidemiological study of dengue in Delhi, India</title><author>Vikram, Kumar ; Nagpal, B.N ; Pande, Veena ; Srivastava, Aruna ; Saxena, Rekha ; Anvikar, Anup ; Das, Aparup ; Singh, Himmat ; Anushrita ; Gupta, Sanjeev K. ; Tuli, N.R. ; Telle, Olivier ; Yadav, N.K. ; Valecha, Neena ; Paul, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-2085ea9ac26c9e9f0e445cd10dcf1c9d7a1ee066cc87bebb905aa07ef430970b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asymptomatic infection</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dengue</topic><topic>Dengue - epidemiology</topic><topic>Dengue Virus - isolation & purification</topic><topic>Emerging diseases</topic><topic>Epidemiologic Studies</topic><topic>Female</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Index case</topic><topic>India - epidemiology</topic><topic>Infant</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mass Screening - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Primary dengue infection</topic><topic>Secondary dengue infection</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vikram, Kumar</creatorcontrib><creatorcontrib>Nagpal, B.N</creatorcontrib><creatorcontrib>Pande, Veena</creatorcontrib><creatorcontrib>Srivastava, Aruna</creatorcontrib><creatorcontrib>Saxena, Rekha</creatorcontrib><creatorcontrib>Anvikar, Anup</creatorcontrib><creatorcontrib>Das, Aparup</creatorcontrib><creatorcontrib>Singh, Himmat</creatorcontrib><creatorcontrib>Anushrita</creatorcontrib><creatorcontrib>Gupta, Sanjeev K.</creatorcontrib><creatorcontrib>Tuli, N.R.</creatorcontrib><creatorcontrib>Telle, Olivier</creatorcontrib><creatorcontrib>Yadav, N.K.</creatorcontrib><creatorcontrib>Valecha, Neena</creatorcontrib><creatorcontrib>Paul, Richard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vikram, Kumar</au><au>Nagpal, B.N</au><au>Pande, Veena</au><au>Srivastava, Aruna</au><au>Saxena, Rekha</au><au>Anvikar, Anup</au><au>Das, Aparup</au><au>Singh, Himmat</au><au>Anushrita</au><au>Gupta, Sanjeev K.</au><au>Tuli, N.R.</au><au>Telle, Olivier</au><au>Yadav, N.K.</au><au>Valecha, Neena</au><au>Paul, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An epidemiological study of dengue in Delhi, India</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2016-01</date><risdate>2016</risdate><volume>153</volume><spage>21</spage><epage>27</epage><pages>21-27</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><abstract>[Display omitted]
•Targeting the index cases in different socio-economic groups of a community to evaluate the prospective dengue cases for proactive readiness of a resource limited health infrastructure.•Inclusion of asymptomatic dengue cases to ascertain the true burden of the disease load for better prevention and control.•Assessing the rate of secondary infections in a community for a possible prevention of developing Dengue Haemorrhagic Fever/ Dengue Shock Syndrome.
Delhi, the capital of India, is an important metropolitan hub for major financial and sociocultural exchanges, offering challenging threats to current public health infrastructure. In recent past, an upsurge of dengue cases in Delhi posed a significant menace to the existing dengue control policies. To reform the control strategies and take timely intervention to prevent future epidemics, an epidemiological study on the proportion of both asymptomatic and symptomatic dengue infections in selected population was conducted. The aim of the study was to investigate and assess the epidemiology of dengue infection and to estimate the proportion of asymptomatic and symptomatic dengue infections in Delhi. In this study, around 50 confirmed dengue cases, a total of 2125 individuals as household and neighbourhood contacts, with or without dengue febrile illness, were finger pricked and serologically detected as dengue positive or negative using SD Duo Bioline Rapid Diagnostic Test (SD Inc, Korea) with NS1, IgM & IgG combo test, which detected dengue virus antigen and antibodies to dengue virus in human blood. Out of 2125 individuals, 768 (36.1%) individuals showed positive dengue test with past (25.5%), primary (1.88%) or secondary (8.8%) dengue infections. Higher percentage of IgG was found in age groups 15–24 years and 25–50 years (36% each). Infants (<1 year) presented higher incidence of new infections (22% of NS1+IgM positives) as compared to adults. Further analysis revealed that out of the 226 newly infected cases (including NS1 and IgM positives), 142 (63%) were asymptomatic and 84 (37%) were symptomatic, as per WHO guidelines. Our findings also suggest that out of the total population screened, 10.6% dengue infection was either primary or secondary. On the basis of these results, it may be hypothesized that there are large number of asymptomatic dengue infections in the community as compared to reported symptomatic cases in Delhi. For the effective control of dengue transmission in such community like Delhi where dengue epidemics have frequently been encountered, it is essential to ascertain the proportion of asymptomatic dengue infections which may act as a reservoir for dengue transmission, as well as threat for developing dengue haemorrhagic fever (DHF).</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26433076</pmid><doi>10.1016/j.actatropica.2015.09.025</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9473-8406</orcidid><orcidid>https://orcid.org/0000-0002-0665-5089</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-706X |
| ispartof | Acta tropica, 2016-01, Vol.153, p.21-27 |
| issn | 0001-706X 1873-6254 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_pasteur_01370785v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Asymptomatic infection Child Child, Preschool Dengue Dengue - epidemiology Dengue Virus - isolation & purification Emerging diseases Epidemiologic Studies Female Human health and pathology Humans Incidence Index case India - epidemiology Infant Life Sciences Male Mass Screening - statistics & numerical data Middle Aged Primary dengue infection Secondary dengue infection Young Adult |
| title | An epidemiological study of dengue in Delhi, India |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T05%3A50%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20epidemiological%20study%20of%20dengue%20in%20Delhi,%20India&rft.jtitle=Acta%20tropica&rft.au=Vikram,%20Kumar&rft.date=2016-01&rft.volume=153&rft.spage=21&rft.epage=27&rft.pages=21-27&rft.issn=0001-706X&rft.eissn=1873-6254&rft_id=info:doi/10.1016/j.actatropica.2015.09.025&rft_dat=%3Cproquest_hal_p%3E1735903616%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1735903616&rft_id=info:pmid/26433076&rft_els_id=S0001706X15301169&rfr_iscdi=true |