Human Coronavirus OC43 Associated with Fatal Encephalitis
In this case report, severe encephalitis with no established cause developed in a child with SCID. Through deep sequencing, human coronavirus OC43 was identified in brain tissue. To the Editor: Encephalitis is a serious neurologic syndrome characterized by brain inflammation that may be fatal. Altho...
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| Veröffentlicht in: | The New England journal of medicine 2016-08, Vol.375 (5), p.497-498 |
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| container_title | The New England journal of medicine |
| container_volume | 375 |
| creator | Morfopoulou, Sofia Brown, Julianne R Davies, E. Graham Anderson, Glenn Virasami, Alex Qasim, Waseem Chong, Wui K Hubank, Michael Plagnol, Vincent Desforges, Marc Jacques, Thomas S Talbot, Pierre J Breuer, Judith |
| description | In this case report, severe encephalitis with no established cause developed in a child with SCID. Through deep sequencing, human coronavirus OC43 was identified in brain tissue.
To the Editor:
Encephalitis is a serious neurologic syndrome characterized by brain inflammation that may be fatal. Although the majority of cases are caused by viruses, the identification of a causal organism can be difficult. Encephalopathy that affects patients with immunodeficiency is particularly challenging to diagnose, since the clinical presentation may be atypical and the differential diagnosis may include unusual pathogens or a noninfective cause. Deep sequencing of clinical samples has the potential to identify the pathogens associated with encephalitis, particularly in cases in which traditional techniques have not identified the candidate causative pathogen.
1
Here we report the use of . . . |
| doi_str_mv | 10.1056/NEJMc1509458 |
| format | Article |
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To the Editor:
Encephalitis is a serious neurologic syndrome characterized by brain inflammation that may be fatal. Although the majority of cases are caused by viruses, the identification of a causal organism can be difficult. Encephalopathy that affects patients with immunodeficiency is particularly challenging to diagnose, since the clinical presentation may be atypical and the differential diagnosis may include unusual pathogens or a noninfective cause. Deep sequencing of clinical samples has the potential to identify the pathogens associated with encephalitis, particularly in cases in which traditional techniques have not identified the candidate causative pathogen.
1
Here we report the use of . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc1509458</identifier><identifier>PMID: 27518687</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Biopsy ; Brain research ; Coronavirus Infections - pathology ; Coronavirus Infections - virology ; Coronavirus OC43, Human - isolation & purification ; Coronaviruses ; Encephalitis ; Encephalitis, Viral - pathology ; Encephalitis, Viral - virology ; Fatal Outcome ; Humans ; Infant ; Infections ; Life Sciences ; Male ; Pathogens ; Severe acute respiratory syndrome ; Severe combined immunodeficiency ; Severe Combined Immunodeficiency - complications ; Transplants & implants</subject><ispartof>The New England journal of medicine, 2016-08, Vol.375 (5), p.497-498</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-2fbe7831ae32f1a426514c3c838a80c5b7319db7ca66c371efefb8f79674778e3</citedby><cites>FETCH-LOGICAL-c547t-2fbe7831ae32f1a426514c3c838a80c5b7319db7ca66c371efefb8f79674778e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc1509458$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1809588343?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,781,785,886,2760,2761,26108,27929,27930,52387,54069,64390,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27518687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://pasteur.hal.science/pasteur-01356388$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Morfopoulou, Sofia</creatorcontrib><creatorcontrib>Brown, Julianne R</creatorcontrib><creatorcontrib>Davies, E. Graham</creatorcontrib><creatorcontrib>Anderson, Glenn</creatorcontrib><creatorcontrib>Virasami, Alex</creatorcontrib><creatorcontrib>Qasim, Waseem</creatorcontrib><creatorcontrib>Chong, Wui K</creatorcontrib><creatorcontrib>Hubank, Michael</creatorcontrib><creatorcontrib>Plagnol, Vincent</creatorcontrib><creatorcontrib>Desforges, Marc</creatorcontrib><creatorcontrib>Jacques, Thomas S</creatorcontrib><creatorcontrib>Talbot, Pierre J</creatorcontrib><creatorcontrib>Breuer, Judith</creatorcontrib><title>Human Coronavirus OC43 Associated with Fatal Encephalitis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this case report, severe encephalitis with no established cause developed in a child with SCID. Through deep sequencing, human coronavirus OC43 was identified in brain tissue.
To the Editor:
Encephalitis is a serious neurologic syndrome characterized by brain inflammation that may be fatal. Although the majority of cases are caused by viruses, the identification of a causal organism can be difficult. Encephalopathy that affects patients with immunodeficiency is particularly challenging to diagnose, since the clinical presentation may be atypical and the differential diagnosis may include unusual pathogens or a noninfective cause. Deep sequencing of clinical samples has the potential to identify the pathogens associated with encephalitis, particularly in cases in which traditional techniques have not identified the candidate causative pathogen.
1
Here we report the use of . . .</description><subject>Biopsy</subject><subject>Brain research</subject><subject>Coronavirus Infections - pathology</subject><subject>Coronavirus Infections - virology</subject><subject>Coronavirus OC43, Human - isolation & purification</subject><subject>Coronaviruses</subject><subject>Encephalitis</subject><subject>Encephalitis, Viral - pathology</subject><subject>Encephalitis, Viral - virology</subject><subject>Fatal Outcome</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Pathogens</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe combined immunodeficiency</subject><subject>Severe Combined Immunodeficiency - complications</subject><subject>Transplants & implants</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0LtPwzAQBnALgWh5bMwoEowE7JxfGauopaBCF5gtx3VUV80DOynivycopWLgllt--u70IXRF8D3BjD-8Tp9fDGE4pUweoTFhADGlmB-jMcaJjKlIYYTOQtjgfghNT9EoEYxILsUYpfOu1FWU1b6u9M75LkTLjEI0CaE2Trd2FX26dh3NdKu30bQytlnrrWtduEAnhd4Ge7nf5-h9Nn3L5vFi-fiUTRaxYVS0cVLkVkgg2kJSEE0Tzgg1YCRILbFhuQCSrnJhNOcGBLGFLXJZiJQLKoS0cI7iIbe_qxrvSu2_VK2dmk8WqtGhtZ1XmADjIOWO9P5m8I2vPzobWrWpO1_1LyoiccqkBAq9uhuU8XUI3haHaILVT6_qb689v96HdnlpVwf8W2QPbgdQlkFVdlP-n_MNaFR7SQ</recordid><startdate>20160804</startdate><enddate>20160804</enddate><creator>Morfopoulou, Sofia</creator><creator>Brown, Julianne R</creator><creator>Davies, E. Graham</creator><creator>Anderson, Glenn</creator><creator>Virasami, Alex</creator><creator>Qasim, Waseem</creator><creator>Chong, Wui K</creator><creator>Hubank, Michael</creator><creator>Plagnol, Vincent</creator><creator>Desforges, Marc</creator><creator>Jacques, Thomas S</creator><creator>Talbot, Pierre J</creator><creator>Breuer, Judith</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>1XC</scope></search><sort><creationdate>20160804</creationdate><title>Human Coronavirus OC43 Associated with Fatal Encephalitis</title><author>Morfopoulou, Sofia ; Brown, Julianne R ; Davies, E. Graham ; Anderson, Glenn ; Virasami, Alex ; Qasim, Waseem ; Chong, Wui K ; Hubank, Michael ; Plagnol, Vincent ; Desforges, Marc ; Jacques, Thomas S ; Talbot, Pierre J ; Breuer, Judith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-2fbe7831ae32f1a426514c3c838a80c5b7319db7ca66c371efefb8f79674778e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biopsy</topic><topic>Brain research</topic><topic>Coronavirus Infections - pathology</topic><topic>Coronavirus Infections - virology</topic><topic>Coronavirus OC43, Human - isolation & purification</topic><topic>Coronaviruses</topic><topic>Encephalitis</topic><topic>Encephalitis, Viral - pathology</topic><topic>Encephalitis, Viral - virology</topic><topic>Fatal Outcome</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Pathogens</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe combined immunodeficiency</topic><topic>Severe Combined Immunodeficiency - complications</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morfopoulou, Sofia</creatorcontrib><creatorcontrib>Brown, Julianne R</creatorcontrib><creatorcontrib>Davies, E. Graham</creatorcontrib><creatorcontrib>Anderson, Glenn</creatorcontrib><creatorcontrib>Virasami, Alex</creatorcontrib><creatorcontrib>Qasim, Waseem</creatorcontrib><creatorcontrib>Chong, Wui K</creatorcontrib><creatorcontrib>Hubank, Michael</creatorcontrib><creatorcontrib>Plagnol, Vincent</creatorcontrib><creatorcontrib>Desforges, Marc</creatorcontrib><creatorcontrib>Jacques, Thomas S</creatorcontrib><creatorcontrib>Talbot, Pierre J</creatorcontrib><creatorcontrib>Breuer, Judith</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morfopoulou, Sofia</au><au>Brown, Julianne R</au><au>Davies, E. Graham</au><au>Anderson, Glenn</au><au>Virasami, Alex</au><au>Qasim, Waseem</au><au>Chong, Wui K</au><au>Hubank, Michael</au><au>Plagnol, Vincent</au><au>Desforges, Marc</au><au>Jacques, Thomas S</au><au>Talbot, Pierre J</au><au>Breuer, Judith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Coronavirus OC43 Associated with Fatal Encephalitis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2016-08-04</date><risdate>2016</risdate><volume>375</volume><issue>5</issue><spage>497</spage><epage>498</epage><pages>497-498</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>In this case report, severe encephalitis with no established cause developed in a child with SCID. Through deep sequencing, human coronavirus OC43 was identified in brain tissue.
To the Editor:
Encephalitis is a serious neurologic syndrome characterized by brain inflammation that may be fatal. Although the majority of cases are caused by viruses, the identification of a causal organism can be difficult. Encephalopathy that affects patients with immunodeficiency is particularly challenging to diagnose, since the clinical presentation may be atypical and the differential diagnosis may include unusual pathogens or a noninfective cause. Deep sequencing of clinical samples has the potential to identify the pathogens associated with encephalitis, particularly in cases in which traditional techniques have not identified the candidate causative pathogen.
1
Here we report the use of . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>27518687</pmid><doi>10.1056/NEJMc1509458</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2016-08, Vol.375 (5), p.497-498 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Biopsy Brain research Coronavirus Infections - pathology Coronavirus Infections - virology Coronavirus OC43, Human - isolation & purification Coronaviruses Encephalitis Encephalitis, Viral - pathology Encephalitis, Viral - virology Fatal Outcome Humans Infant Infections Life Sciences Male Pathogens Severe acute respiratory syndrome Severe combined immunodeficiency Severe Combined Immunodeficiency - complications Transplants & implants |
| title | Human Coronavirus OC43 Associated with Fatal Encephalitis |
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