Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication

The metabolic sensor mTOR broadly regulates cell growth and division in cancer cells, leading to a significant focus on studies of rapamycin and its analogues as candidate anticancer drugs. However, mTOR inhibitors have failed to produce useful clinical efficacy, potentially because mTOR is also cri...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-08, Vol.75 (16), p.3279-3291
Hauptverfasser:	Chaoul, Nada, Fayolle, Catherine, Desrues, Belinda, Oberkampf, Marine, Tang, Alexandre, Ladant, Daniel, Leclerc, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - immunology Antibiotics, Antineoplastic - pharmacology Cancer Vaccines - administration & dosage Cancer Vaccines - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Disease Models, Animal Female Flow Cytometry Humans Life Sciences Mice, Inbred C57BL Myeloid Cells - drug effects Myeloid Cells - immunology Myeloid Cells - metabolism Neoplasms - immunology Neoplasms - metabolism Neoplasms - prevention & control Papillomavirus E7 Proteins - immunology Sirolimus - immunology Sirolimus - pharmacology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - immunology TOR Serine-Threonine Kinases - metabolism Tumor Burden - drug effects Tumor Burden - immunology
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