A Complex Equilibrium among Partially Unfolded Conformations in Monomeric Transthyretin

Aggregation of transthyretin (TTR) is known to be linked to the development of systemic and localized amyloidoses. It also appears that TTR exerts a protective role against aggregation of the Aβ peptide, a process linked to Alzheimer’s disease. In vitro, both processes correlate with the ability of...

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Veröffentlicht in:	Biochemistry (Easton) 2014-07, Vol.53 (27), p.4381-4392
Hauptverfasser:	Conti, Simona, Li, Xinyi, Gianni, Stefano, Ghadami, Seyyed Abolghasem, Buxbaum, Joel, Cecchi, Cristina, Chiti, Fabrizio, Bemporad, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Humans Isomerism Kinetics Life Sciences Proline Proline - chemistry Protein Conformation Protein Denaturation Protein Folding Protein Multimerization Protein Unfolding Transferrin Transferrin - chemistry
Online-Zugang:	Volltext
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