Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children
Background Osteocalcin, a protein secreted by osteoblasts during bone formation, is negatively associated with adult periodontal disease. Little is known about this association in children. Aim To examine the extent to which plasma undercarboxylated osteocalcin (ucOC) is associated with gingival cre...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical periodontology 2014-05, Vol.41 (5), p.467-472 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 472 |
|---|---|
| container_issue | 5 |
| container_start_page | 467 |
| container_title | Journal of clinical periodontology |
| container_volume | 41 |
| creator | Kâ, Khady Rousseau, Marie-Claude Tran, Simon D. Kaartinen, Mari T. Myneni, Vamsee D. Henderson, Mélanie Nicolau, Belinda |
| description | Background
Osteocalcin, a protein secreted by osteoblasts during bone formation, is negatively associated with adult periodontal disease. Little is known about this association in children.
Aim
To examine the extent to which plasma undercarboxylated osteocalcin (ucOC) is associated with gingival crevicular fluid tumour necrosis factor‐alpha (GCF TNF‐α) – a potential marker of gingival inflammation – in children.
Methods
We used data from the Quebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study on the natural history of obesity among Caucasian children with a family history of obesity in Quebec, Canada. This cross‐sectional analysis from the baseline visit includes 120 children aged 8–10 years. Plasma ucOC and GCF TNF‐α levels were determined by enzyme‐linked immunosorbent assay. Linear regression analyses, adjusting for age, gender, family income, sexual maturity stage, daily physical activity, obesity, and fasting glucose were conducted, with TNF‐α level as the dependent variable.
Results
A 1‐ng/ml increase in ucOC was associated with a 0.96% decrease (95% confidence interval (CI): −1.69, −0.23) in GCF TNF‐α level.
Conclusion
A negative association between a marker of bone formation and a marker of gingival inflammation was observed as early as childhood among Caucasian children with a family history of obesity. |
| doi_str_mv | 10.1111/jcpe.12232 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_pasteur_01135751v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1524400073</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4742-efdf16019c190580c1713cb914221d3f22c78a4f81fecf941548060cad9e27e63</originalsourceid><addsrcrecordid>eNqFkcFuEzEYhC0EoqFw4QGQjwhpy__b3nX2WEUlAUVQBAjExXK8duvi3U3t3dA8Fi_CM-GQNEfwxZL1zcgzQ8hzhDPM5_WNWdszZIyzB2SCFUABJX57SCbAgRdVLesT8iSlGwCUnPPH5IQJUYGUYkLamY9mDHrw3RUdu8ZGo-Oqv9vmJ9vQPg22NzoY31HdNfQqY36jAzXRbvxOGKkLo2_oMLb9GGlnTeyTT9RpM_Sx-P2LZqm59qGJtntKHjkdkn12uE_JlzcXn2eLYvlh_nZ2viyMkIIV1jUu58DaYA3lFAxK5GZVo2AMG-4YM3KqhZuis8bVAksxhQqMbmrLpK34KSn2vtc6qHX0rY5b1WuvFudLtdY51BgVIPJSlrjBzL_c8-vY3442Dar1ydgQdGf7MSksc2MAkOv7P4pCsBq5yOirPbqrJEXrjl9BULvl1G459Xe5DL84-I6r1jZH9H6qDOAe-OmD3f7DSr2bXV7cmx568Dny3VGj4w9VSS5L9fX9XMHs43xx-V2oT_wPugSz4g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514429134</pqid></control><display><type>article</type><title>Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kâ, Khady ; Rousseau, Marie-Claude ; Tran, Simon D. ; Kaartinen, Mari T. ; Myneni, Vamsee D. ; Henderson, Mélanie ; Nicolau, Belinda</creator><creatorcontrib>Kâ, Khady ; Rousseau, Marie-Claude ; Tran, Simon D. ; Kaartinen, Mari T. ; Myneni, Vamsee D. ; Henderson, Mélanie ; Nicolau, Belinda</creatorcontrib><description>Background
Osteocalcin, a protein secreted by osteoblasts during bone formation, is negatively associated with adult periodontal disease. Little is known about this association in children.
Aim
To examine the extent to which plasma undercarboxylated osteocalcin (ucOC) is associated with gingival crevicular fluid tumour necrosis factor‐alpha (GCF TNF‐α) – a potential marker of gingival inflammation – in children.
Methods
We used data from the Quebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study on the natural history of obesity among Caucasian children with a family history of obesity in Quebec, Canada. This cross‐sectional analysis from the baseline visit includes 120 children aged 8–10 years. Plasma ucOC and GCF TNF‐α levels were determined by enzyme‐linked immunosorbent assay. Linear regression analyses, adjusting for age, gender, family income, sexual maturity stage, daily physical activity, obesity, and fasting glucose were conducted, with TNF‐α level as the dependent variable.
Results
A 1‐ng/ml increase in ucOC was associated with a 0.96% decrease (95% confidence interval (CI): −1.69, −0.23) in GCF TNF‐α level.
Conclusion
A negative association between a marker of bone formation and a marker of gingival inflammation was observed as early as childhood among Caucasian children with a family history of obesity.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12232</identifier><identifier>PMID: 24460774</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Biomarkers - analysis ; Blood Glucose - analysis ; Body Mass Index ; Body Weight ; bone ; Child ; Cohort Studies ; Cross-Sectional Studies ; Dental Calculus - classification ; Dental Plaque - classification ; Dentistry ; Fasting ; Female ; Gingival Crevicular Fluid - chemistry ; gingivitis ; Gingivitis - metabolism ; Human health and pathology ; Humans ; Income ; inflammation ; Life Sciences ; Longitudinal Studies ; Male ; Motor Activity ; obesity ; Obesity - blood ; Obesity - metabolism ; osteocalcin ; Osteocalcin - blood ; Osteogenesis - physiology ; periodontal diseases ; Periodontal Index ; Sexual Maturation ; Tumor Necrosis Factor-alpha - analysis ; tumour necrosis factor-alpha</subject><ispartof>Journal of clinical periodontology, 2014-05, Vol.41 (5), p.467-472</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4742-efdf16019c190580c1713cb914221d3f22c78a4f81fecf941548060cad9e27e63</citedby><cites>FETCH-LOGICAL-c4742-efdf16019c190580c1713cb914221d3f22c78a4f81fecf941548060cad9e27e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.12232$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.12232$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24460774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://riip.hal.science/pasteur-01135751$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Kâ, Khady</creatorcontrib><creatorcontrib>Rousseau, Marie-Claude</creatorcontrib><creatorcontrib>Tran, Simon D.</creatorcontrib><creatorcontrib>Kaartinen, Mari T.</creatorcontrib><creatorcontrib>Myneni, Vamsee D.</creatorcontrib><creatorcontrib>Henderson, Mélanie</creatorcontrib><creatorcontrib>Nicolau, Belinda</creatorcontrib><title>Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Background
Osteocalcin, a protein secreted by osteoblasts during bone formation, is negatively associated with adult periodontal disease. Little is known about this association in children.
Aim
To examine the extent to which plasma undercarboxylated osteocalcin (ucOC) is associated with gingival crevicular fluid tumour necrosis factor‐alpha (GCF TNF‐α) – a potential marker of gingival inflammation – in children.
Methods
We used data from the Quebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study on the natural history of obesity among Caucasian children with a family history of obesity in Quebec, Canada. This cross‐sectional analysis from the baseline visit includes 120 children aged 8–10 years. Plasma ucOC and GCF TNF‐α levels were determined by enzyme‐linked immunosorbent assay. Linear regression analyses, adjusting for age, gender, family income, sexual maturity stage, daily physical activity, obesity, and fasting glucose were conducted, with TNF‐α level as the dependent variable.
Results
A 1‐ng/ml increase in ucOC was associated with a 0.96% decrease (95% confidence interval (CI): −1.69, −0.23) in GCF TNF‐α level.
Conclusion
A negative association between a marker of bone formation and a marker of gingival inflammation was observed as early as childhood among Caucasian children with a family history of obesity.</description><subject>Biomarkers - analysis</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>bone</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Dental Calculus - classification</subject><subject>Dental Plaque - classification</subject><subject>Dentistry</subject><subject>Fasting</subject><subject>Female</subject><subject>Gingival Crevicular Fluid - chemistry</subject><subject>gingivitis</subject><subject>Gingivitis - metabolism</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Income</subject><subject>inflammation</subject><subject>Life Sciences</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Motor Activity</subject><subject>obesity</subject><subject>Obesity - blood</subject><subject>Obesity - metabolism</subject><subject>osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>Osteogenesis - physiology</subject><subject>periodontal diseases</subject><subject>Periodontal Index</subject><subject>Sexual Maturation</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>tumour necrosis factor-alpha</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuEzEYhC0EoqFw4QGQjwhpy__b3nX2WEUlAUVQBAjExXK8duvi3U3t3dA8Fi_CM-GQNEfwxZL1zcgzQ8hzhDPM5_WNWdszZIyzB2SCFUABJX57SCbAgRdVLesT8iSlGwCUnPPH5IQJUYGUYkLamY9mDHrw3RUdu8ZGo-Oqv9vmJ9vQPg22NzoY31HdNfQqY36jAzXRbvxOGKkLo2_oMLb9GGlnTeyTT9RpM_Sx-P2LZqm59qGJtntKHjkdkn12uE_JlzcXn2eLYvlh_nZ2viyMkIIV1jUu58DaYA3lFAxK5GZVo2AMG-4YM3KqhZuis8bVAksxhQqMbmrLpK34KSn2vtc6qHX0rY5b1WuvFudLtdY51BgVIPJSlrjBzL_c8-vY3442Dar1ydgQdGf7MSksc2MAkOv7P4pCsBq5yOirPbqrJEXrjl9BULvl1G459Xe5DL84-I6r1jZH9H6qDOAe-OmD3f7DSr2bXV7cmx568Dny3VGj4w9VSS5L9fX9XMHs43xx-V2oT_wPugSz4g</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Kâ, Khady</creator><creator>Rousseau, Marie-Claude</creator><creator>Tran, Simon D.</creator><creator>Kaartinen, Mari T.</creator><creator>Myneni, Vamsee D.</creator><creator>Henderson, Mélanie</creator><creator>Nicolau, Belinda</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>1XC</scope></search><sort><creationdate>201405</creationdate><title>Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children</title><author>Kâ, Khady ; Rousseau, Marie-Claude ; Tran, Simon D. ; Kaartinen, Mari T. ; Myneni, Vamsee D. ; Henderson, Mélanie ; Nicolau, Belinda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4742-efdf16019c190580c1713cb914221d3f22c78a4f81fecf941548060cad9e27e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomarkers - analysis</topic><topic>Blood Glucose - analysis</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>bone</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Dental Calculus - classification</topic><topic>Dental Plaque - classification</topic><topic>Dentistry</topic><topic>Fasting</topic><topic>Female</topic><topic>Gingival Crevicular Fluid - chemistry</topic><topic>gingivitis</topic><topic>Gingivitis - metabolism</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Income</topic><topic>inflammation</topic><topic>Life Sciences</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Motor Activity</topic><topic>obesity</topic><topic>Obesity - blood</topic><topic>Obesity - metabolism</topic><topic>osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>Osteogenesis - physiology</topic><topic>periodontal diseases</topic><topic>Periodontal Index</topic><topic>Sexual Maturation</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>tumour necrosis factor-alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kâ, Khady</creatorcontrib><creatorcontrib>Rousseau, Marie-Claude</creatorcontrib><creatorcontrib>Tran, Simon D.</creatorcontrib><creatorcontrib>Kaartinen, Mari T.</creatorcontrib><creatorcontrib>Myneni, Vamsee D.</creatorcontrib><creatorcontrib>Henderson, Mélanie</creatorcontrib><creatorcontrib>Nicolau, Belinda</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kâ, Khady</au><au>Rousseau, Marie-Claude</au><au>Tran, Simon D.</au><au>Kaartinen, Mari T.</au><au>Myneni, Vamsee D.</au><au>Henderson, Mélanie</au><au>Nicolau, Belinda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2014-05</date><risdate>2014</risdate><volume>41</volume><issue>5</issue><spage>467</spage><epage>472</epage><pages>467-472</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Background
Osteocalcin, a protein secreted by osteoblasts during bone formation, is negatively associated with adult periodontal disease. Little is known about this association in children.
Aim
To examine the extent to which plasma undercarboxylated osteocalcin (ucOC) is associated with gingival crevicular fluid tumour necrosis factor‐alpha (GCF TNF‐α) – a potential marker of gingival inflammation – in children.
Methods
We used data from the Quebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study on the natural history of obesity among Caucasian children with a family history of obesity in Quebec, Canada. This cross‐sectional analysis from the baseline visit includes 120 children aged 8–10 years. Plasma ucOC and GCF TNF‐α levels were determined by enzyme‐linked immunosorbent assay. Linear regression analyses, adjusting for age, gender, family income, sexual maturity stage, daily physical activity, obesity, and fasting glucose were conducted, with TNF‐α level as the dependent variable.
Results
A 1‐ng/ml increase in ucOC was associated with a 0.96% decrease (95% confidence interval (CI): −1.69, −0.23) in GCF TNF‐α level.
Conclusion
A negative association between a marker of bone formation and a marker of gingival inflammation was observed as early as childhood among Caucasian children with a family history of obesity.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24460774</pmid><doi>10.1111/jcpe.12232</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-6979 |
| ispartof | Journal of clinical periodontology, 2014-05, Vol.41 (5), p.467-472 |
| issn | 0303-6979 1600-051X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_pasteur_01135751v1 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biomarkers - analysis Blood Glucose - analysis Body Mass Index Body Weight bone Child Cohort Studies Cross-Sectional Studies Dental Calculus - classification Dental Plaque - classification Dentistry Fasting Female Gingival Crevicular Fluid - chemistry gingivitis Gingivitis - metabolism Human health and pathology Humans Income inflammation Life Sciences Longitudinal Studies Male Motor Activity obesity Obesity - blood Obesity - metabolism osteocalcin Osteocalcin - blood Osteogenesis - physiology periodontal diseases Periodontal Index Sexual Maturation Tumor Necrosis Factor-alpha - analysis tumour necrosis factor-alpha |
| title | Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T23%3A48%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20undercarboxylated%20osteocalcin%20and%20gingival%20crevicular%20fluid%20tumour%20necrosis%20factor-%CE%B1%20in%20children&rft.jtitle=Journal%20of%20clinical%20periodontology&rft.au=K%C3%A2,%20Khady&rft.date=2014-05&rft.volume=41&rft.issue=5&rft.spage=467&rft.epage=472&rft.pages=467-472&rft.issn=0303-6979&rft.eissn=1600-051X&rft_id=info:doi/10.1111/jcpe.12232&rft_dat=%3Cproquest_hal_p%3E1524400073%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1514429134&rft_id=info:pmid/24460774&rfr_iscdi=true |