The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae

The COP9 signalosome (CSN) is a highly conserved eukaryotic protein complex which regulates the cullin RING family of ubiquitin ligases and carries out a deneddylase activity that resides in subunit 5 (CSN5). Whereas CSN activity is essential for the development of higher eukaryotes, several unicell...

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Veröffentlicht in:	The FEBS journal 2014-01, Vol.281 (1), p.175-190
Hauptverfasser:	Licursi, Valerio, Salvi, Chiara, De Cesare, Virginia, Rinaldi, Teresa, Mattei, Benedetta, Fabbri, Claudia, Serino, Giovanna, Bramasole, Laylan, Zimbler, Jacob Z., Pick, Elah, Barnes, Brett M., Bard, Martin, Negri, Rodolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabidopsis thaliana Aspergillus nidulans Biochemistry, Molecular Biology Biological Markers Biomarkers - metabolism Biosynthesis Blotting, Western Chromatography, Gas Chromatography, Liquid COP9 signalosome COP9 Signalosome Complex Cullin Proteins Cullin Proteins - metabolism Drosophila melanogaster Ergosterol Ergosterol - metabolism ergosterol biosynthesis Eukaryotes Gene Expression Profiling Life Sciences Lipid Metabolism Lipids Metabolism Metalloendopeptidases Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Multiprotein Complexes Multiprotein Complexes - metabolism neddylation Oligonucleotide Array Sequence Analysis Peptide Hydrolases Peptide Hydrolases - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger RNA, Messenger - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Tandem Mass Spectrometry Transition Elements Transition Elements - metabolism Yeast Zinc Zinc - metabolism zinc uptake
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