Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor

► VEGFR2 is an important tumor-associated receptor on the endothelial cells. ► Blockade of the VEGFR2with nanobody lead to the inhibition of neovascularization. ► VEGFR2-specific nanobody can recognize antigen on the cell surface by FACS. ► VEGFR2 nanobody potently inhibited endothelial tube formati...

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Veröffentlicht in:	Molecular immunology 2012-02, Vol.50 (1-2), p.35-41
Hauptverfasser:	Behdani, Mahdi, Zeinali, Sirous, Khanahmad, Hossein, Karimipour, Morteza, Asadzadeh, Nader, Azadmanesh, Keyhan, Khabiri, Alireza, Schoonooghe, Steve, Habibi Anbouhi, Mahdi, Hassanzadeh-Ghassabeh, Gholamreza, Muyldermans, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiogenesis Angiogenesis Inhibitors Angiogenesis Inhibitors - immunology Angiogenesis Inhibitors - metabolism Angiogenesis Inhibitors - pharmacology Animals Antibody Specificity Antibody Specificity - immunology Camelids, New World Cells, Cultured Electrophoresis, Polyacrylamide Gel Flow Cytometry Genetics HEK293 Cells Human Umbilical Vein Endothelial Cells Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - immunology Human Umbilical Vein Endothelial Cells - physiology Humans Immune Sera Immune Sera - immunology Kinetics Life Sciences Male Molecular Sequence Data Nanobody Neovascularization, Physiologic Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - immunology Protein Binding Protein Binding - immunology Sequence Homology, Amino Acid Signal Transduction Signal Transduction - immunology Single-Chain Antibodies Single-Chain Antibodies - genetics Single-Chain Antibodies - immunology Single-Chain Antibodies - pharmacology Surface Plasmon Resonance Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factor Receptor-2 - immunology Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGFR2
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