Bidirectional interactions between bone metabolism and hematopoiesis
Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process oc...
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| Veröffentlicht in: | Experimental hematology 2011-08, Vol.39 (8), p.809-816 |
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| container_title | Experimental hematology |
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| creator | Despars, Geneviève St-Pierre, Yves |
| description | Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow. |
| doi_str_mv | 10.1016/j.exphem.2011.04.008 |
| format | Article |
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| ispartof | Experimental hematology, 2011-08, Vol.39 (8), p.809-816 |
| issn | 0301-472X 1873-2399 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Advanced Basic Science Animals Bone and Bones Bone and Bones - cytology Bone and Bones - metabolism Bone Marrow Bone Marrow - metabolism Bone Marrow Cells Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Adhesion Molecules Cell Adhesion Molecules - metabolism Hematology Hematology, Oncology and Palliative Medicine Hematopoiesis Hematopoietic Stem Cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Human health and pathology Humans Infectious diseases Life Sciences Mesenchymal Stem Cells Mesenchymal Stromal Cells - metabolism Models, Biological |
| title | Bidirectional interactions between bone metabolism and hematopoiesis |
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