A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε

Type I interferon （IFN） signaling is the principal response mediating antiviral innate immunity. IFN transcription is dependent upon the activation of transcription factors IRF3/IRF7 and NF-KB. Many viral proteins have been shown as being capable of interfering with IFN signaling to facilitate evasi...

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Veröffentlicht in:	Cell research 2011-05, Vol.21 (5), p.793-806
Hauptverfasser:	Liang, Deguang, Gao, Yuan, Lin, Xianzhi, He, Zhiheng, Zhao, Qinglan, Deng, Qiang, Lan, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 3' Untranslated Regions - genetics Animals Base Sequence Cell Line Data processing Down-Regulation HEK293 Cells Herpesvirus 8, Human Herpesvirus 8, Human - genetics Herpesvirus 8, Human - physiology Human herpesvirus Human herpesvirus 8 Humans I-kappa B Kinase I-kappa B Kinase - genetics I-kappa B Kinase - metabolism IKK Immune response Immunity Infection Interferon Interferon regulatory factor 3 Interferon regulatory factor 7 Interferons Interferons - metabolism Kaposi's sarcoma-associated herpesvirus Life Sciences Microbiology and Parasitology MicroRNAs MicroRNAs - metabolism miRNA Molecular Sequence Data NF- Kappa B protein Phosphorylation Sarcoma, Kaposi Sarcoma, Kaposi - virology Signal Transduction Transcription factors Vesicular stomatitis virus Virology Virus Activation Virus Latency 信号延迟干扰素抗病毒药物潜伏期疱疹病毒维护
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