Contribution of IL-17-producing {gamma}{delta} T cells to the efficacy of anticancer chemotherapy

By triggering immunogenic cell death, some anticancer compounds, including anthracyclines and oxaliplatin, elicit tumor-specific, interferon-γ-producing CD8(+) αβ T lymphocytes (Tc1 CTLs) that are pivotal for an optimal therapeutic outcome. Here, we demonstrate that chemotherapy induces a rapid and...

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Veröffentlicht in:The Journal of experimental medicine 2011-03, Vol.208 (3), p.491-503
Hauptverfasser: Ma, Yuting, Aymeric, Laetitia, Locher, Clara, Mattarollo, Stephen R, Delahaye, Nicolas F, Pereira, Pablo, Boucontet, Laurent, Apetoh, Lionel, Ghiringhelli, François, Casares, Noëlia, Lasarte, Juan José, Matsuzaki, Goro, Ikuta, Koichi, Ryffel, Bernhard, Benlagha, Kamel, Tesnière, Antoine, Ibrahim, Nicolas, Déchanet-Merville, Julie, Chaput, Nathalie, Smyth, Mark J, Kroemer, Guido, Zitvogel, Laurence
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Sprache:eng
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