Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells

Retinoic acid-related orphan receptor (ROR)γt(+) TCRαβ(+) cells expressing IL-17, termed Th17 cells, are most abundant in the intestinal lamina propria. Symbiotic microbiota are required for the generation of Th17 cells, but the requirement for microbiota-derived Ag is not documented. In this study,...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-02, Vol.186 (3), p.1531-1537
Hauptverfasser:	Lochner, Matthias, Bérard, Marion, Sawa, Shinichiro, Hauer, Siona, Gaboriau-Routhiau, Valérie, Fernandez, Tahia Diana, Snel, Johannes, Bousso, Philippe, Cerf-Bensussan, Nadine, Eberl, Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals CD4 Lymphocyte Count Cell Differentiation - genetics Cell Differentiation - immunology Cell Proliferation Female Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics Germ-Free Life - genetics Germ-Free Life - immunology Gram-Positive Bacterial Infections - immunology Gram-Positive Bacterial Infections - pathology Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics Immunology Interleukin-17 - biosynthesis Interleukin-17 - genetics Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Life Sciences Lymphocyte Activation - genetics Lymphocyte Activation - immunology Male Mice Mice, Knockout Mice, Transgenic Molecular Sequence Data Nuclear Receptor Subfamily 1, Group F, Member 3 - biosynthesis Nuclear Receptor Subfamily 1, Group F, Member 3 - deficiency Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Receptors, Antigen, T-Cell - deficiency Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - physiology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - microbiology T-Lymphocytes, Helper-Inducer - pathology
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