Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization

We have studied the effect of cyclosporin A (CSA) on the expression of genes involved in the immune response in mice bearing a transgenic T cell receptor specific for the peptide 88–104 of the pigeon cytochrome c. Immunization of mice treated with CSA resulted in the blockade of the IL2, IFN-γ, CXCR...

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Veröffentlicht in:	Immunology letters 2002-11, Vol.84 (2), p.137-143
Hauptverfasser:	Mascarell, Laurent, Truffa-Bachi, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Antigens, CD Antigens, CD - biosynthesis Antigens, CD - drug effects Cell surface molecule Cells, Cultured Cyclosporine Cyclosporine - pharmacology Cytochrome c Group Cytochrome c Group - genetics Cytochrome c Group - immunology Cytochrome c Group - pharmacology Cytokines Cytokines - drug effects Cytokines - genetics Cytokines - immunology Female Flow Cytometry Gene Expression Gene Expression - drug effects Immunization Immunology Immunomodulators Immunosuppressive Agents Immunosuppressive Agents - pharmacology Life Sciences Lymphocyte Activation Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Mice, Transgenic Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Chemokine Receptors, Chemokine - drug effects Receptors, Chemokine - genetics Receptors, Chemokine - immunology Receptors, Chemokine - metabolism Reverse Transcriptase Polymerase Chain Reaction T lymphocyte T-Lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology Transcription, Genetic Transcription, Genetic - drug effects
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