Apoptosis Inversely Correlates with Rabies Virus Neurotropism

: We report that non‐neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase‐dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat‐vect), but also a caspase‐independent pathway. Cell redistribution of the apoptosis‐in...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.598-603
Hauptverfasser: THOULOUZE, MARIA-ISABEL, LAFAGE, MIREILLE, YUSTE, VICTOR J., KROEMER, GUIDO, SUSIN, SANTOS A., ISRAEL, NICOLE, LAFON, MONIQUE
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container_title Annals of the New York Academy of Sciences
container_volume 1010
creator THOULOUZE, MARIA-ISABEL
LAFAGE, MIREILLE
YUSTE, VICTOR J.
KROEMER, GUIDO
SUSIN, SANTOS A.
ISRAEL, NICOLE
LAFON, MONIQUE
description : We report that non‐neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase‐dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat‐vect), but also a caspase‐independent pathway. Cell redistribution of the apoptosis‐inducing factor (AIF) was observed in Jurkat‐vect infected with RV vaccine strain. Bcl‐2 overproduction in Jurkat T cells (Jurkat‐Bcl‐2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system.
doi_str_mv 10.1196/annals.1299.112
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Cell redistribution of the apoptosis‐inducing factor (AIF) was observed in Jurkat‐vect infected with RV vaccine strain. Bcl‐2 overproduction in Jurkat T cells (Jurkat‐Bcl‐2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. 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subjects AIF
Apoptosis
Apoptosis - physiology
Apoptosis Inducing Factor
Bcl-2
Biochemistry, Molecular Biology
Brain
Brain - virology
caspase
Caspases
Caspases - metabolism
Flavoproteins
Flavoproteins - metabolism
Humans
Jurkat Cells
Jurkat T cells
Life Sciences
live virus vaccine
Membrane Proteins
Membrane Proteins - metabolism
Molecular biology
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-bcl-2 - genetics
Rabies virus
Rabies virus - pathogenicity
title Apoptosis Inversely Correlates with Rabies Virus Neurotropism
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