Apoptosis Inversely Correlates with Rabies Virus Neurotropism
: We report that non‐neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase‐dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat‐vect), but also a caspase‐independent pathway. Cell redistribution of the apoptosis‐in...
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Veröffentlicht in: | Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.598-603 |
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creator | THOULOUZE, MARIA-ISABEL LAFAGE, MIREILLE YUSTE, VICTOR J. KROEMER, GUIDO SUSIN, SANTOS A. ISRAEL, NICOLE LAFON, MONIQUE |
description | : We report that non‐neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase‐dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat‐vect), but also a caspase‐independent pathway. Cell redistribution of the apoptosis‐inducing factor (AIF) was observed in Jurkat‐vect infected with RV vaccine strain. Bcl‐2 overproduction in Jurkat T cells (Jurkat‐Bcl‐2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system. |
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Cell redistribution of the apoptosis‐inducing factor (AIF) was observed in Jurkat‐vect infected with RV vaccine strain. Bcl‐2 overproduction in Jurkat T cells (Jurkat‐Bcl‐2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1299.112</identifier><identifier>PMID: 15033799</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>AIF ; Apoptosis ; Apoptosis - physiology ; Apoptosis Inducing Factor ; Bcl-2 ; Biochemistry, Molecular Biology ; Brain ; Brain - virology ; caspase ; Caspases ; Caspases - metabolism ; Flavoproteins ; Flavoproteins - metabolism ; Humans ; Jurkat Cells ; Jurkat T cells ; Life Sciences ; live virus vaccine ; Membrane Proteins ; Membrane Proteins - metabolism ; Molecular biology ; Proto-Oncogene Proteins c-bcl-2 ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Rabies virus ; Rabies virus - pathogenicity</subject><ispartof>Annals of the New York Academy of Sciences, 2003-12, Vol.1010 (1), p.598-603</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4148-6433121188ce971275e591e484d3ccb2b1d03a2eb58acd49944d4aed31ef65623</citedby><cites>FETCH-LOGICAL-c4148-6433121188ce971275e591e484d3ccb2b1d03a2eb58acd49944d4aed31ef65623</cites><orcidid>0000-0002-9334-4405 ; 0000-0002-3366-1628 ; 0000-0002-4423-7996 ; 0000-0002-1780-0421</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1299.112$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1299.112$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15033799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://pasteur.hal.science/pasteur-00193959$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>THOULOUZE, MARIA-ISABEL</creatorcontrib><creatorcontrib>LAFAGE, MIREILLE</creatorcontrib><creatorcontrib>YUSTE, VICTOR J.</creatorcontrib><creatorcontrib>KROEMER, GUIDO</creatorcontrib><creatorcontrib>SUSIN, SANTOS A.</creatorcontrib><creatorcontrib>ISRAEL, NICOLE</creatorcontrib><creatorcontrib>LAFON, MONIQUE</creatorcontrib><title>Apoptosis Inversely Correlates with Rabies Virus Neurotropism</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: We report that non‐neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase‐dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat‐vect), but also a caspase‐independent pathway. Cell redistribution of the apoptosis‐inducing factor (AIF) was observed in Jurkat‐vect infected with RV vaccine strain. Bcl‐2 overproduction in Jurkat T cells (Jurkat‐Bcl‐2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system.</description><subject>AIF</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Apoptosis Inducing Factor</subject><subject>Bcl-2</subject><subject>Biochemistry, Molecular Biology</subject><subject>Brain</subject><subject>Brain - virology</subject><subject>caspase</subject><subject>Caspases</subject><subject>Caspases - metabolism</subject><subject>Flavoproteins</subject><subject>Flavoproteins - metabolism</subject><subject>Humans</subject><subject>Jurkat Cells</subject><subject>Jurkat T cells</subject><subject>Life Sciences</subject><subject>live virus vaccine</subject><subject>Membrane Proteins</subject><subject>Membrane Proteins - metabolism</subject><subject>Molecular biology</subject><subject>Proto-Oncogene Proteins c-bcl-2</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>Rabies virus</subject><subject>Rabies virus - pathogenicity</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1v2zAQxYmiReMknbsVmrop4fFDJIcOhtF8AIYLJE2LdiEo6YywlU2VlJL4vw8NGcnYhUccfvfu3iPkI9AzAFOdu-3WdekMmDG5wd6QGShhyqri7C2ZUapUqQ3jR-Q4pT-UAtNCvSdHICnnypgZ-TLvQz-E5FNxvX3AmLDbFYsQI3ZuwFQ8-uG-uHG1z_8fPo6pWOEYwxBD79PmlLxb5_344VBPyN3F1--Lq3L57fJ6MV-WjQChy0pwDgxA6waNAqYkSgMotGh509SshpZyx7CW2jWtMEaIVjhsOeC6khXjJ6ScdO9dZ_voNy7ubHDeXs2XtndpyDfZbM9wI80DZP7zxPcx_BsxDXbjU4Nd57YYxmQVyIrmJ4PnE9jEkFLE9Ys6ULtP2E4J233CubE_5dNBeqw32L7yh0gzICbg0Xe4-5-eXf2a30qjXy367ObpZczFv7ZSXEn7c3Vpb1cCfsONtow_Azp_lyE</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>THOULOUZE, MARIA-ISABEL</creator><creator>LAFAGE, MIREILLE</creator><creator>YUSTE, VICTOR J.</creator><creator>KROEMER, GUIDO</creator><creator>SUSIN, SANTOS A.</creator><creator>ISRAEL, NICOLE</creator><creator>LAFON, MONIQUE</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9334-4405</orcidid><orcidid>https://orcid.org/0000-0002-3366-1628</orcidid><orcidid>https://orcid.org/0000-0002-4423-7996</orcidid><orcidid>https://orcid.org/0000-0002-1780-0421</orcidid></search><sort><creationdate>200312</creationdate><title>Apoptosis Inversely Correlates with Rabies Virus Neurotropism</title><author>THOULOUZE, MARIA-ISABEL ; LAFAGE, MIREILLE ; YUSTE, VICTOR J. ; KROEMER, GUIDO ; SUSIN, SANTOS A. ; ISRAEL, NICOLE ; LAFON, MONIQUE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4148-6433121188ce971275e591e484d3ccb2b1d03a2eb58acd49944d4aed31ef65623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>AIF</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Apoptosis Inducing Factor</topic><topic>Bcl-2</topic><topic>Biochemistry, Molecular Biology</topic><topic>Brain</topic><topic>Brain - virology</topic><topic>caspase</topic><topic>Caspases</topic><topic>Caspases - metabolism</topic><topic>Flavoproteins</topic><topic>Flavoproteins - metabolism</topic><topic>Humans</topic><topic>Jurkat Cells</topic><topic>Jurkat T cells</topic><topic>Life Sciences</topic><topic>live virus vaccine</topic><topic>Membrane Proteins</topic><topic>Membrane Proteins - metabolism</topic><topic>Molecular biology</topic><topic>Proto-Oncogene Proteins c-bcl-2</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Rabies virus</topic><topic>Rabies virus - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOULOUZE, MARIA-ISABEL</creatorcontrib><creatorcontrib>LAFAGE, MIREILLE</creatorcontrib><creatorcontrib>YUSTE, VICTOR J.</creatorcontrib><creatorcontrib>KROEMER, GUIDO</creatorcontrib><creatorcontrib>SUSIN, SANTOS A.</creatorcontrib><creatorcontrib>ISRAEL, NICOLE</creatorcontrib><creatorcontrib>LAFON, MONIQUE</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THOULOUZE, MARIA-ISABEL</au><au>LAFAGE, MIREILLE</au><au>YUSTE, VICTOR J.</au><au>KROEMER, GUIDO</au><au>SUSIN, SANTOS A.</au><au>ISRAEL, NICOLE</au><au>LAFON, MONIQUE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis Inversely Correlates with Rabies Virus Neurotropism</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2003-12</date><risdate>2003</risdate><volume>1010</volume><issue>1</issue><spage>598</spage><epage>603</epage><pages>598-603</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: We report that non‐neurotropic rabies virus (RV) strains, currently used to immunize wildlife against rabies, induces not only a caspase‐dependent apoptosis in the human lymphoblastoid Jurkat T cell line (Jurkat‐vect), but also a caspase‐independent pathway. Cell redistribution of the apoptosis‐inducing factor (AIF) was observed in Jurkat‐vect infected with RV vaccine strain. Bcl‐2 overproduction in Jurkat T cells (Jurkat‐Bcl‐2) abolished both caspase activation and AIF distribution. In contrast, strain of neurotropic RV did not induce apoptosis. The inverse correlation of the induction of apoptosis and the capacity of a virus strain to invade the brain suggests that blockage of apoptosis could be a strategy selected by neurotropic virus to favor its progression through the nervous system.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15033799</pmid><doi>10.1196/annals.1299.112</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9334-4405</orcidid><orcidid>https://orcid.org/0000-0002-3366-1628</orcidid><orcidid>https://orcid.org/0000-0002-4423-7996</orcidid><orcidid>https://orcid.org/0000-0002-1780-0421</orcidid></addata></record> |
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subjects | AIF Apoptosis Apoptosis - physiology Apoptosis Inducing Factor Bcl-2 Biochemistry, Molecular Biology Brain Brain - virology caspase Caspases Caspases - metabolism Flavoproteins Flavoproteins - metabolism Humans Jurkat Cells Jurkat T cells Life Sciences live virus vaccine Membrane Proteins Membrane Proteins - metabolism Molecular biology Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-bcl-2 - genetics Rabies virus Rabies virus - pathogenicity |
title | Apoptosis Inversely Correlates with Rabies Virus Neurotropism |
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