Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

The chemical synthesis of new compounds designed as inhibitors of Mycobacterium tuberculosis TMP kinase (TMPK) is reported. The synthesis concerns TMP analogues modified at the 5-position of the thymine ring as well as a novel compound with a six-membered sugar ring. The binding properties of the an...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2003-02, Vol.278 (7), p.4963-4971
Hauptverfasser:	Haouz, Ahmed, Vanheusden, Veerle, Munier-Lehmann, Hélène, Froeyen, Mattheus, Herdewijn, Piet, Van Calenbergh, Serge, Delarue, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain Drug Design Enzyme Inhibitors Enzyme Inhibitors - analysis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Nucleoside-Phosphate Kinase Nucleoside-Phosphate Kinase - antagonists & inhibitors Protein Conformation Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!