Neuronal fate determinants of adult olfactory bulb neurogenesis
Adult neurogenesis in mammals is restricted to two small regions, including the olfactory bulb, where GABAergic and dopaminergic interneurons are newly generated throughout the entire lifespan. However, the mechanisms directing them towards a specific neuronal phenotype are not yet understood. Here,...
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| Veröffentlicht in: | Nature neuroscience 2005-07, Vol.8 (7), p.865-872 |
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| creator | Hack, Michael A Saghatelyan, Armen de Chevigny, Antoine Pfeifer, Alexander Ashery-Padan, Ruth Lledo, Pierre-Marie Götz, Magdalena |
| description | Adult neurogenesis in mammals is restricted to two small regions, including the olfactory bulb, where GABAergic and dopaminergic interneurons are newly generated throughout the entire lifespan. However, the mechanisms directing them towards a specific neuronal phenotype are not yet understood. Here, we demonstrate the dual role of the transcription factor Pax6 in generating neuronal progenitors and also in directing them towards a dopaminergic periglomerular phenotype in adult mice. We present further evidence that dopaminergic periglomerular neurons originate in a distinct niche, the rostral migratory stream, and are fewer derived from precursors in the zone lining the ventricle. This regionalization of the adult precursor cells is further supported by the restricted expression of the transcription factor Olig2, which specifies transit-amplifying precursor fate and opposes the neurogenic role of Pax6. Together, these data explain both extrinsic and intrinsic mechanisms controlling neuronal identity in adult neurogenesis. |
| doi_str_mv | 10.1038/nn1479 |
| format | Article |
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However, the mechanisms directing them towards a specific neuronal phenotype are not yet understood. Here, we demonstrate the dual role of the transcription factor Pax6 in generating neuronal progenitors and also in directing them towards a dopaminergic periglomerular phenotype in adult mice. We present further evidence that dopaminergic periglomerular neurons originate in a distinct niche, the rostral migratory stream, and are fewer derived from precursors in the zone lining the ventricle. This regionalization of the adult precursor cells is further supported by the restricted expression of the transcription factor Olig2, which specifies transit-amplifying precursor fate and opposes the neurogenic role of Pax6. 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hack, Michael A</au><au>Saghatelyan, Armen</au><au>de Chevigny, Antoine</au><au>Pfeifer, Alexander</au><au>Ashery-Padan, Ruth</au><au>Lledo, Pierre-Marie</au><au>Götz, Magdalena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuronal fate determinants of adult olfactory bulb neurogenesis</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>8</volume><issue>7</issue><spage>865</spage><epage>872</epage><pages>865-872</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Adult neurogenesis in mammals is restricted to two small regions, including the olfactory bulb, where GABAergic and dopaminergic interneurons are newly generated throughout the entire lifespan. However, the mechanisms directing them towards a specific neuronal phenotype are not yet understood. Here, we demonstrate the dual role of the transcription factor Pax6 in generating neuronal progenitors and also in directing them towards a dopaminergic periglomerular phenotype in adult mice. We present further evidence that dopaminergic periglomerular neurons originate in a distinct niche, the rostral migratory stream, and are fewer derived from precursors in the zone lining the ventricle. This regionalization of the adult precursor cells is further supported by the restricted expression of the transcription factor Olig2, which specifies transit-amplifying precursor fate and opposes the neurogenic role of Pax6. 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| subjects | Animal Genetics and Genomics Animals Animals, Newborn Basic Helix-Loop-Helix Transcription Factors Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell Division Cell Division - physiology Cell Line Cell Line - physiology Cellular therapy Dopamine Dopamine - metabolism Ependyma Ependyma - cytology Ependyma - growth & development Ependyma - metabolism Eye Proteins Eye Proteins - metabolism Eye Proteins - physiology Genotype & phenotype Health aspects Homeodomain Proteins Homeodomain Proteins - metabolism Homeodomain Proteins - physiology Life Sciences Localization Male Mice Mice, Inbred C57BL Nerve Tissue Proteins Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Neural transmission Neurobiology Neurogenesis Neurons Neurons - cytology Neurons - physiology Neurons and Cognition Neurosciences Olfactory Bulb Olfactory Bulb - cytology Olfactory Bulb - growth & development Olfactory Bulb - metabolism Oligodendrocyte Transcription Factor 2 Oligodendroglia Oligodendroglia - cytology Paired Box Transcription Factors PAX6 Transcription Factor Phenotype Regulation Repressor Proteins Repressor Proteins - metabolism Repressor Proteins - physiology Stem Cells Stem Cells - cytology Tissue Distribution Transcription factors Transplantation immunology |
| title | Neuronal fate determinants of adult olfactory bulb neurogenesis |
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