Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span
Through its antioxidant, anticarcinogenic, and anti‐inflammatory properties, resveratrol has become a candidate for drug development in the context of aging studies. Scientific evidence has highlighted its potential as a therapeutic agent for cardiovascular diseases and some cancers but also as an a...
Gespeichert in:
| Veröffentlicht in: | Annals of the New York Academy of Sciences 2013-07, Vol.1290 (1), p.67-73 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 73 |
|---|---|
| container_issue | 1 |
| container_start_page | 67 |
| container_title | Annals of the New York Academy of Sciences |
| container_volume | 1290 |
| creator | Marchal, Julia Pifferi, Fabien Aujard, Fabienne |
| description | Through its antioxidant, anticarcinogenic, and anti‐inflammatory properties, resveratrol has become a candidate for drug development in the context of aging studies. Scientific evidence has highlighted its potential as a therapeutic agent for cardiovascular diseases and some cancers but also as an antiaging molecule. Resveratrol is thought to mimic the beneficial effects of chronic and moderate calorie restriction. Nevertheless, no study has demonstrated the prolongation of life span in healthy nonobese mammal models. This review summarizes recent findings on the effects of resveratrol on aging and life span in mammals. In our opinion, more studies should be performed to assess the effects of a chronic dietary intake of resveratrol in long‐lived species close to humans, such as nonhuman primates. This will certainly generate more evidence about the ability of resveratrol to achieve the physiological benefits that have been observed in small mammal laboratory models and feature the eventual unwanted secondary effects that may occur under high levels of resveratrol. |
| doi_str_mv | 10.1111/nyas.12214 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_mnhn_02291903v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1400622042</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5294-8b12f21b4ec74e20b5f0ff067c52ba9de30257ebae3a38f5f63d519e7b41df323</originalsourceid><addsrcrecordid>eNqNkUtvEzEURi0EoqFlww9AltggxBQ_x2N2UR8JaigSDwEryzNz3brMeII9KeTf4zRtkFhUeGPp-tyjz_oQekbJIc3nTVjbdEgZo-IBmlAldFGWnD1EE0KUKirN-B56ktIVIZRVQj1Ge4xXUopSTdC3j5CuIdoxDh32Afe2722X3mJwDpox4SFge-HDBa790Nv4A2J6nSdQROjsCC1ufQKbYDMNLe68A5yWNhygRy6L4OntvY--nJ58PpoXiw-zd0fTRdFIpkVR1ZQ5RmsBjRLASC0dcY6UKj_XVrfACZMKagvc8spJV_JWUg2qFrR1nPF99GrrvbSdWUafM67NYL2ZTxemD5fBEMY01YRf0wy_3MLLOPxcQRpN71MDXWcDDKtkqGC6qrhk1X-ghJSMEbGJ8OIf9GpYxZB_bSjXWldESfI3aBOHlCK4XVpKzKZHs-nR3PSY4ee3ylXdQ7tD74rLAN0Cv3wH63tU5vz79NOdtNju-DTC791OLtVko5Lm6_nMlMfvz-bHM20I_wNkxrT2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1399980750</pqid></control><display><type>article</type><title>Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Marchal, Julia ; Pifferi, Fabien ; Aujard, Fabienne</creator><creatorcontrib>Marchal, Julia ; Pifferi, Fabien ; Aujard, Fabienne</creatorcontrib><description>Through its antioxidant, anticarcinogenic, and anti‐inflammatory properties, resveratrol has become a candidate for drug development in the context of aging studies. Scientific evidence has highlighted its potential as a therapeutic agent for cardiovascular diseases and some cancers but also as an antiaging molecule. Resveratrol is thought to mimic the beneficial effects of chronic and moderate calorie restriction. Nevertheless, no study has demonstrated the prolongation of life span in healthy nonobese mammal models. This review summarizes recent findings on the effects of resveratrol on aging and life span in mammals. In our opinion, more studies should be performed to assess the effects of a chronic dietary intake of resveratrol in long‐lived species close to humans, such as nonhuman primates. This will certainly generate more evidence about the ability of resveratrol to achieve the physiological benefits that have been observed in small mammal laboratory models and feature the eventual unwanted secondary effects that may occur under high levels of resveratrol.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/nyas.12214</identifier><identifier>PMID: 23855467</identifier><identifier>CODEN: ANYAA9</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aging ; Aging - drug effects ; Aging - physiology ; Animals ; antiaging strategy ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biomarkers ; Biomarkers - metabolism ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - prevention & control ; Chemical compounds ; Diseases ; Human ; Humans ; Intakes ; Life Sciences ; Life span ; Longevity - drug effects ; Longevity - physiology ; Mammals ; mimetic effect ; nutrition ; Pharmacology ; resveratrol ; Stilbenes - pharmacology ; Stilbenes - therapeutic use</subject><ispartof>Annals of the New York Academy of Sciences, 2013-07, Vol.1290 (1), p.67-73</ispartof><rights>2013 New York Academy of Sciences</rights><rights>2013 New York Academy of Sciences.</rights><rights>2013 The New York Academy of Sciences</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5294-8b12f21b4ec74e20b5f0ff067c52ba9de30257ebae3a38f5f63d519e7b41df323</citedby><cites>FETCH-LOGICAL-c5294-8b12f21b4ec74e20b5f0ff067c52ba9de30257ebae3a38f5f63d519e7b41df323</cites><orcidid>0000-0003-1074-7784 ; 0000-0001-9316-1935</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnyas.12214$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnyas.12214$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23855467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://mnhn.hal.science/mnhn-02291903$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchal, Julia</creatorcontrib><creatorcontrib>Pifferi, Fabien</creatorcontrib><creatorcontrib>Aujard, Fabienne</creatorcontrib><title>Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann. N.Y. Acad. Sci</addtitle><description>Through its antioxidant, anticarcinogenic, and anti‐inflammatory properties, resveratrol has become a candidate for drug development in the context of aging studies. Scientific evidence has highlighted its potential as a therapeutic agent for cardiovascular diseases and some cancers but also as an antiaging molecule. Resveratrol is thought to mimic the beneficial effects of chronic and moderate calorie restriction. Nevertheless, no study has demonstrated the prolongation of life span in healthy nonobese mammal models. This review summarizes recent findings on the effects of resveratrol on aging and life span in mammals. In our opinion, more studies should be performed to assess the effects of a chronic dietary intake of resveratrol in long‐lived species close to humans, such as nonhuman primates. This will certainly generate more evidence about the ability of resveratrol to achieve the physiological benefits that have been observed in small mammal laboratory models and feature the eventual unwanted secondary effects that may occur under high levels of resveratrol.</description><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>antiaging strategy</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Chemical compounds</subject><subject>Diseases</subject><subject>Human</subject><subject>Humans</subject><subject>Intakes</subject><subject>Life Sciences</subject><subject>Life span</subject><subject>Longevity - drug effects</subject><subject>Longevity - physiology</subject><subject>Mammals</subject><subject>mimetic effect</subject><subject>nutrition</subject><subject>Pharmacology</subject><subject>resveratrol</subject><subject>Stilbenes - pharmacology</subject><subject>Stilbenes - therapeutic use</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEURi0EoqFlww9AltggxBQ_x2N2UR8JaigSDwEryzNz3brMeII9KeTf4zRtkFhUeGPp-tyjz_oQekbJIc3nTVjbdEgZo-IBmlAldFGWnD1EE0KUKirN-B56ktIVIZRVQj1Ge4xXUopSTdC3j5CuIdoxDh32Afe2722X3mJwDpox4SFge-HDBa790Nv4A2J6nSdQROjsCC1ufQKbYDMNLe68A5yWNhygRy6L4OntvY--nJ58PpoXiw-zd0fTRdFIpkVR1ZQ5RmsBjRLASC0dcY6UKj_XVrfACZMKagvc8spJV_JWUg2qFrR1nPF99GrrvbSdWUafM67NYL2ZTxemD5fBEMY01YRf0wy_3MLLOPxcQRpN71MDXWcDDKtkqGC6qrhk1X-ghJSMEbGJ8OIf9GpYxZB_bSjXWldESfI3aBOHlCK4XVpKzKZHs-nR3PSY4ee3ylXdQ7tD74rLAN0Cv3wH63tU5vz79NOdtNju-DTC791OLtVko5Lm6_nMlMfvz-bHM20I_wNkxrT2</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Marchal, Julia</creator><creator>Pifferi, Fabien</creator><creator>Aujard, Fabienne</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>L7M</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1074-7784</orcidid><orcidid>https://orcid.org/0000-0001-9316-1935</orcidid></search><sort><creationdate>201307</creationdate><title>Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span</title><author>Marchal, Julia ; Pifferi, Fabien ; Aujard, Fabienne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5294-8b12f21b4ec74e20b5f0ff067c52ba9de30257ebae3a38f5f63d519e7b41df323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aging</topic><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>antiaging strategy</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Chemical compounds</topic><topic>Diseases</topic><topic>Human</topic><topic>Humans</topic><topic>Intakes</topic><topic>Life Sciences</topic><topic>Life span</topic><topic>Longevity - drug effects</topic><topic>Longevity - physiology</topic><topic>Mammals</topic><topic>mimetic effect</topic><topic>nutrition</topic><topic>Pharmacology</topic><topic>resveratrol</topic><topic>Stilbenes - pharmacology</topic><topic>Stilbenes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marchal, Julia</creatorcontrib><creatorcontrib>Pifferi, Fabien</creatorcontrib><creatorcontrib>Aujard, Fabienne</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marchal, Julia</au><au>Pifferi, Fabien</au><au>Aujard, Fabienne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann. N.Y. Acad. Sci</addtitle><date>2013-07</date><risdate>2013</risdate><volume>1290</volume><issue>1</issue><spage>67</spage><epage>73</epage><pages>67-73</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><coden>ANYAA9</coden><abstract>Through its antioxidant, anticarcinogenic, and anti‐inflammatory properties, resveratrol has become a candidate for drug development in the context of aging studies. Scientific evidence has highlighted its potential as a therapeutic agent for cardiovascular diseases and some cancers but also as an antiaging molecule. Resveratrol is thought to mimic the beneficial effects of chronic and moderate calorie restriction. Nevertheless, no study has demonstrated the prolongation of life span in healthy nonobese mammal models. This review summarizes recent findings on the effects of resveratrol on aging and life span in mammals. In our opinion, more studies should be performed to assess the effects of a chronic dietary intake of resveratrol in long‐lived species close to humans, such as nonhuman primates. This will certainly generate more evidence about the ability of resveratrol to achieve the physiological benefits that have been observed in small mammal laboratory models and feature the eventual unwanted secondary effects that may occur under high levels of resveratrol.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23855467</pmid><doi>10.1111/nyas.12214</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1074-7784</orcidid><orcidid>https://orcid.org/0000-0001-9316-1935</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2013-07, Vol.1290 (1), p.67-73 |
| issn | 0077-8923 1749-6632 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_mnhn_02291903v1 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aging Aging - drug effects Aging - physiology Animals antiaging strategy Antioxidants - pharmacology Antioxidants - therapeutic use Biomarkers Biomarkers - metabolism Cardiovascular Diseases - metabolism Cardiovascular Diseases - prevention & control Chemical compounds Diseases Human Humans Intakes Life Sciences Life span Longevity - drug effects Longevity - physiology Mammals mimetic effect nutrition Pharmacology resveratrol Stilbenes - pharmacology Stilbenes - therapeutic use |
| title | Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T10%3A16%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resveratrol%20in%20mammals:%20effects%20on%20aging%20biomarkers,%20age-related%20diseases,%20and%20life%20span&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=Marchal,%20Julia&rft.date=2013-07&rft.volume=1290&rft.issue=1&rft.spage=67&rft.epage=73&rft.pages=67-73&rft.issn=0077-8923&rft.eissn=1749-6632&rft.coden=ANYAA9&rft_id=info:doi/10.1111/nyas.12214&rft_dat=%3Cproquest_hal_p%3E1400622042%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1399980750&rft_id=info:pmid/23855467&rfr_iscdi=true |