Measuring the electrophysiological effects of direct electrical stimulation after awake brain surgery
Objective. Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain, and guide tumour resection during awake neurosurgery. Nonetheless, the electrophysiological effects of DES remain largely unknown, both locally and remotely. Approach. In this study,...
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| Veröffentlicht in: | Journal of neural engineering 2020-02, Vol.17 (1), p.016047-016047, Article 016047 |
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| creator | Vincent, M A Bonnetblanc, F Mandonnet, E Boyer, A Duffau, H Guiraud, D |
| description | Objective. Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain, and guide tumour resection during awake neurosurgery. Nonetheless, the electrophysiological effects of DES remain largely unknown, both locally and remotely. Approach. In this study, we lowered the DES frequency to 1-10 Hz and we used a differential recording mode of electro-corticographic (ECoG) signals to improve the focality with a simple algorithm to remove the artefacts due to the response of the acquisition chain. Main results. Doing so, we were able to observe different components in the evoked potentials triggered by simulating the cortex or the subcortical white matter pathways near the recording electrodes and by stimulating the cortex remotely from the recording site. More particularly, P0 and N1 components were repeatedly observed on raw ECoG signals without the need to average the data. Significance. This new methodology is important to probe the electrophysiological states and the connectivity of the brain in vivo and in real time, namely to perform electrophysiological brain mapping on human patients operated in the neurosurgical room and to better understand the electrophysiological spreading of DES. |
| doi_str_mv | 10.1088/1741-2552/ab5cdd |
| format | Article |
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Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain, and guide tumour resection during awake neurosurgery. Nonetheless, the electrophysiological effects of DES remain largely unknown, both locally and remotely. Approach. In this study, we lowered the DES frequency to 1-10 Hz and we used a differential recording mode of electro-corticographic (ECoG) signals to improve the focality with a simple algorithm to remove the artefacts due to the response of the acquisition chain. Main results. Doing so, we were able to observe different components in the evoked potentials triggered by simulating the cortex or the subcortical white matter pathways near the recording electrodes and by stimulating the cortex remotely from the recording site. More particularly, P0 and N1 components were repeatedly observed on raw ECoG signals without the need to average the data. Significance. This new methodology is important to probe the electrophysiological states and the connectivity of the brain in vivo and in real time, namely to perform electrophysiological brain mapping on human patients operated in the neurosurgical room and to better understand the electrophysiological spreading of DES.</description><identifier>ISSN: 1741-2560</identifier><identifier>ISSN: 1741-2552</identifier><identifier>EISSN: 1741-2552</identifier><identifier>DOI: 10.1088/1741-2552/ab5cdd</identifier><identifier>PMID: 31778987</identifier><identifier>CODEN: JNEIEZ</identifier><language>eng</language><publisher>BRISTOL: IOP Publishing</publisher><subject>Action Potentials - physiology ; Automatic ; awake brain surgery ; Brain - physiology ; Brain - surgery ; Brain Mapping - instrumentation ; Brain Mapping - methods ; direct electrical stimulation ; electrocorticography ; Electrocorticography - methods ; Engineering ; Engineering Sciences ; Engineering, Biomedical ; evoked potential ; Human health and pathology ; Humans ; Life Sciences ; Life Sciences & Biomedicine ; Neurobiology ; Neurons and Cognition ; Neurosciences ; Neurosciences & Neurology ; Neurosurgical Procedures - methods ; Science & Technology ; Stereotaxic Techniques ; Technology ; Tissues and Organs ; Wakefulness - physiology</subject><ispartof>Journal of neural engineering, 2020-02, Vol.17 (1), p.016047-016047, Article 016047</ispartof><rights>2020 IOP Publishing Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>11</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000530820600004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c438t-d328e75cc051aa04656dcf4770f35e6bd52ebd871d87ea055c4b066dda09f4c73</citedby><cites>FETCH-LOGICAL-c438t-d328e75cc051aa04656dcf4770f35e6bd52ebd871d87ea055c4b066dda09f4c73</cites><orcidid>0000-0002-4184-6243 ; 0000-0002-1761-7491 ; 0000-0003-0230-9282 ; 0000-0002-6558-2342 ; 0000-0002-7167-9183</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1741-2552/ab5cdd/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>230,315,782,786,887,27933,27934,28257,53855,53902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31778987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal-lirmm.ccsd.cnrs.fr/lirmm-02390467$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vincent, M A</creatorcontrib><creatorcontrib>Bonnetblanc, F</creatorcontrib><creatorcontrib>Mandonnet, E</creatorcontrib><creatorcontrib>Boyer, A</creatorcontrib><creatorcontrib>Duffau, H</creatorcontrib><creatorcontrib>Guiraud, D</creatorcontrib><title>Measuring the electrophysiological effects of direct electrical stimulation after awake brain surgery</title><title>Journal of neural engineering</title><addtitle>JNE</addtitle><addtitle>J NEURAL ENG</addtitle><addtitle>J. Neural Eng</addtitle><description>Objective. Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain, and guide tumour resection during awake neurosurgery. Nonetheless, the electrophysiological effects of DES remain largely unknown, both locally and remotely. Approach. In this study, we lowered the DES frequency to 1-10 Hz and we used a differential recording mode of electro-corticographic (ECoG) signals to improve the focality with a simple algorithm to remove the artefacts due to the response of the acquisition chain. Main results. Doing so, we were able to observe different components in the evoked potentials triggered by simulating the cortex or the subcortical white matter pathways near the recording electrodes and by stimulating the cortex remotely from the recording site. More particularly, P0 and N1 components were repeatedly observed on raw ECoG signals without the need to average the data. Significance. This new methodology is important to probe the electrophysiological states and the connectivity of the brain in vivo and in real time, namely to perform electrophysiological brain mapping on human patients operated in the neurosurgical room and to better understand the electrophysiological spreading of DES.</description><subject>Action Potentials - physiology</subject><subject>Automatic</subject><subject>awake brain surgery</subject><subject>Brain - physiology</subject><subject>Brain - surgery</subject><subject>Brain Mapping - instrumentation</subject><subject>Brain Mapping - methods</subject><subject>direct electrical stimulation</subject><subject>electrocorticography</subject><subject>Electrocorticography - methods</subject><subject>Engineering</subject><subject>Engineering Sciences</subject><subject>Engineering, Biomedical</subject><subject>evoked potential</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Neurobiology</subject><subject>Neurons and Cognition</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Neurosurgical Procedures - methods</subject><subject>Science & Technology</subject><subject>Stereotaxic Techniques</subject><subject>Technology</subject><subject>Tissues and Organs</subject><subject>Wakefulness - physiology</subject><issn>1741-2560</issn><issn>1741-2552</issn><issn>1741-2552</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhSNERUvhzgnliATbju04do7VCijSol7K2XLs8a5LEi920mr_Pd5mCSckDtaMxt97Gs0rincErghIeU1ERVaUc3qtW26sfVFcLKOXS1_DefE6pQcARkQDr4rzXIVspLgo8DvqNEU_bMtxhyV2aMYY9rtD8qELW290V6JzeZrK4ErrY25P2PNnGn0_dXr0YSi1GzGW-kn_xLKN2g9ltt5iPLwpzpzuEr491cvix5fP9-vb1ebu67f1zWZlKibHlWVUouDGACdaQ1Xz2hpXCQGOcaxbyym2VgqSH2rg3FQt1LW1GhpXGcEui4-z7053ah99r-NBBe3V7c1GdT72vQLKmuwsHkmmP8z0PoZfE6ZR9T4Z7Do9YJiSoowCE7VoaEZhRk0MKUV0izsBdYxCHW-tjndXcxRZ8v7kPrU92kXw5_Z_l33CNrhkPA4GFwwAOANJoc4dVJmW_0-v_ficyDpMw5iln2apD3v1EKY45Az-vfhvf3y1gw</recordid><startdate>20200205</startdate><enddate>20200205</enddate><creator>Vincent, M A</creator><creator>Bonnetblanc, F</creator><creator>Mandonnet, E</creator><creator>Boyer, A</creator><creator>Duffau, H</creator><creator>Guiraud, D</creator><general>IOP Publishing</general><general>Iop Publishing Ltd</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-4184-6243</orcidid><orcidid>https://orcid.org/0000-0002-1761-7491</orcidid><orcidid>https://orcid.org/0000-0003-0230-9282</orcidid><orcidid>https://orcid.org/0000-0002-6558-2342</orcidid><orcidid>https://orcid.org/0000-0002-7167-9183</orcidid></search><sort><creationdate>20200205</creationdate><title>Measuring the electrophysiological effects of direct electrical stimulation after awake brain surgery</title><author>Vincent, M A ; Bonnetblanc, F ; Mandonnet, E ; Boyer, A ; Duffau, H ; Guiraud, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-d328e75cc051aa04656dcf4770f35e6bd52ebd871d87ea055c4b066dda09f4c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Action Potentials - physiology</topic><topic>Automatic</topic><topic>awake brain surgery</topic><topic>Brain - physiology</topic><topic>Brain - surgery</topic><topic>Brain Mapping - instrumentation</topic><topic>Brain Mapping - methods</topic><topic>direct electrical stimulation</topic><topic>electrocorticography</topic><topic>Electrocorticography - methods</topic><topic>Engineering</topic><topic>Engineering Sciences</topic><topic>Engineering, Biomedical</topic><topic>evoked potential</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Life Sciences & Biomedicine</topic><topic>Neurobiology</topic><topic>Neurons and Cognition</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Neurosurgical Procedures - methods</topic><topic>Science & Technology</topic><topic>Stereotaxic Techniques</topic><topic>Technology</topic><topic>Tissues and Organs</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vincent, M A</creatorcontrib><creatorcontrib>Bonnetblanc, F</creatorcontrib><creatorcontrib>Mandonnet, E</creatorcontrib><creatorcontrib>Boyer, A</creatorcontrib><creatorcontrib>Duffau, H</creatorcontrib><creatorcontrib>Guiraud, D</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of neural engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vincent, M A</au><au>Bonnetblanc, F</au><au>Mandonnet, E</au><au>Boyer, A</au><au>Duffau, H</au><au>Guiraud, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measuring the electrophysiological effects of direct electrical stimulation after awake brain surgery</atitle><jtitle>Journal of neural engineering</jtitle><stitle>JNE</stitle><stitle>J NEURAL ENG</stitle><addtitle>J. Neural Eng</addtitle><date>2020-02-05</date><risdate>2020</risdate><volume>17</volume><issue>1</issue><spage>016047</spage><epage>016047</epage><pages>016047-016047</pages><artnum>016047</artnum><issn>1741-2560</issn><issn>1741-2552</issn><eissn>1741-2552</eissn><coden>JNEIEZ</coden><abstract>Objective. Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain, and guide tumour resection during awake neurosurgery. Nonetheless, the electrophysiological effects of DES remain largely unknown, both locally and remotely. Approach. In this study, we lowered the DES frequency to 1-10 Hz and we used a differential recording mode of electro-corticographic (ECoG) signals to improve the focality with a simple algorithm to remove the artefacts due to the response of the acquisition chain. Main results. Doing so, we were able to observe different components in the evoked potentials triggered by simulating the cortex or the subcortical white matter pathways near the recording electrodes and by stimulating the cortex remotely from the recording site. More particularly, P0 and N1 components were repeatedly observed on raw ECoG signals without the need to average the data. Significance. This new methodology is important to probe the electrophysiological states and the connectivity of the brain in vivo and in real time, namely to perform electrophysiological brain mapping on human patients operated in the neurosurgical room and to better understand the electrophysiological spreading of DES.</abstract><cop>BRISTOL</cop><pub>IOP Publishing</pub><pmid>31778987</pmid><doi>10.1088/1741-2552/ab5cdd</doi><tpages>25</tpages><orcidid>https://orcid.org/0000-0002-4184-6243</orcidid><orcidid>https://orcid.org/0000-0002-1761-7491</orcidid><orcidid>https://orcid.org/0000-0003-0230-9282</orcidid><orcidid>https://orcid.org/0000-0002-6558-2342</orcidid><orcidid>https://orcid.org/0000-0002-7167-9183</orcidid></addata></record> |
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| subjects | Action Potentials - physiology Automatic awake brain surgery Brain - physiology Brain - surgery Brain Mapping - instrumentation Brain Mapping - methods direct electrical stimulation electrocorticography Electrocorticography - methods Engineering Engineering Sciences Engineering, Biomedical evoked potential Human health and pathology Humans Life Sciences Life Sciences & Biomedicine Neurobiology Neurons and Cognition Neurosciences Neurosciences & Neurology Neurosurgical Procedures - methods Science & Technology Stereotaxic Techniques Technology Tissues and Organs Wakefulness - physiology |
| title | Measuring the electrophysiological effects of direct electrical stimulation after awake brain surgery |
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