Increased risk of cardiac ischaemia in a pan-European cohort of 36 205 childhood cancer survivors: a PanCareSurFup study
ObjectiveIn this report, we determine the cumulative incidence of symptomatic cardiac ischaemia and its risk factors among European 5-year childhood cancer survivors (CCS) participating in the PanCareSurFup study.MethodsEight data providers (France, Hungary, Italy (two cohorts), the Netherlands, Slo...
Gespeichert in:
| Veröffentlicht in: | Heart (British Cardiac Society) 2021-01, Vol.107 (1), p.33-41 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 41 |
|---|---|
| container_issue | 1 |
| container_start_page | 33 |
| container_title | Heart (British Cardiac Society) |
| container_volume | 107 |
| creator | Feijen, Elizabeth Arnoldina Maria van Dalen, Elvira C van der Pal, Heleen J H Reulen, Raoul C Winter, David L Kuehni, Claudia E Morsellino, Vera Alessi, Daniela Allodji, Rodrigue S Byrne, Julliana Bardi, Edit Jakab, Zsuzsanna Grabow, Desiree Garwicz, Stanislaw Haddy, Nadia Jankovic, Momcilo Kaatsch, Peter Levitt, Gill A Ronckers, Cecile M Schindera, Christina Skinner, Roderick Zalatel, Lorna Hjorth, Lars Tissing, Wim J E De Vathaire, Florent Hawkins, Mike M Kremer, Leontien C M |
| description | ObjectiveIn this report, we determine the cumulative incidence of symptomatic cardiac ischaemia and its risk factors among European 5-year childhood cancer survivors (CCS) participating in the PanCareSurFup study.MethodsEight data providers (France, Hungary, Italy (two cohorts), the Netherlands, Slovenia, Switzerland and the UK) participating in PanCareSurFup ascertained and validated symptomatic cardiac events among their 36 205 eligible CCS. Data on symptomatic cardiac ischaemia were graded according to the Criteria for Adverse Events V.3.0 (grade 3–5). We calculated cumulative incidences, both overall and for different subgroups based on treatment and malignancy, and used multivariable Cox regression to analyse risk factors.ResultsOverall, 302 out of the 36 205 CCS developed symptomatic cardiac ischaemia during follow-up (median follow-up time after primary cancer diagnosis: 23.0 years). The cumulative incidence by age 60 was 5.4% (95% CI 4.6% to 6.2%). Men (7.1% (95% CI 5.8 to 8.4)) had higher rates than women (3.4% (95% CI 2.4 to 4.4)) (p |
| doi_str_mv | 10.1136/heartjnl-2020-316655 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_inserm_04439043v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2436392865</sourcerecordid><originalsourceid>FETCH-LOGICAL-b499t-36b33953d7769ea01ba5e0563c54c2840f45b320b114a520e550522fcafcee4f3</originalsourceid><addsrcrecordid>eNqNkV2L1DAUhoso7of-A5GAN15YN8lJMq13y7DrLgwoqOBdOE1TmrFNxqQd3H9vZrs7ghfiVUJ4npdz8hbFK0bfMwbqorcYp60fSk45LYEpJeWT4pQJVeUn9v1pvoOUpaKwOinOUtpSSkVdqefFCfCKK17J0-LXrTfRYrItiS79IKEjBmPr0BCXTI92dEicJ0h26MurOYadRU9M6EOcDjQowqkkpndD24fQZt0bG0ma497tQ0wfsvsZ_Rqj_TLH63lH0jS3dy-KZx0Oyb58OM-Lb9dXX9c35ebTx9v15aZsRF1PJagGoJbQrlaqtkhZg9JSqcBIYXglaCdkA5w2jAmUnFopqeS8M9gZa0UH58W7JbfHQe-iGzHe6YBO31xutPPJxlFTIaCmAvYs428XfBfDz9mmSY_5H-wwoLdhTpoLUFDzSsmMvvkL3YY5-rxMplQtVgD3lFgoE0NK0XbHIRjVhyL1Y5H6UKReisza64fwuRlte5Qem8vAxQI04_Z_I-kf4zjqP5XfRxm4Fg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2469473365</pqid></control><display><type>article</type><title>Increased risk of cardiac ischaemia in a pan-European cohort of 36 205 childhood cancer survivors: a PanCareSurFup study</title><source>PubMed Central</source><creator>Feijen, Elizabeth Arnoldina Maria ; van Dalen, Elvira C ; van der Pal, Heleen J H ; Reulen, Raoul C ; Winter, David L ; Kuehni, Claudia E ; Morsellino, Vera ; Alessi, Daniela ; Allodji, Rodrigue S ; Byrne, Julliana ; Bardi, Edit ; Jakab, Zsuzsanna ; Grabow, Desiree ; Garwicz, Stanislaw ; Haddy, Nadia ; Jankovic, Momcilo ; Kaatsch, Peter ; Levitt, Gill A ; Ronckers, Cecile M ; Schindera, Christina ; Skinner, Roderick ; Zalatel, Lorna ; Hjorth, Lars ; Tissing, Wim J E ; De Vathaire, Florent ; Hawkins, Mike M ; Kremer, Leontien C M</creator><creatorcontrib>Feijen, Elizabeth Arnoldina Maria ; van Dalen, Elvira C ; van der Pal, Heleen J H ; Reulen, Raoul C ; Winter, David L ; Kuehni, Claudia E ; Morsellino, Vera ; Alessi, Daniela ; Allodji, Rodrigue S ; Byrne, Julliana ; Bardi, Edit ; Jakab, Zsuzsanna ; Grabow, Desiree ; Garwicz, Stanislaw ; Haddy, Nadia ; Jankovic, Momcilo ; Kaatsch, Peter ; Levitt, Gill A ; Ronckers, Cecile M ; Schindera, Christina ; Skinner, Roderick ; Zalatel, Lorna ; Hjorth, Lars ; Tissing, Wim J E ; De Vathaire, Florent ; Hawkins, Mike M ; Kremer, Leontien C M ; PanCareSurFup consortium</creatorcontrib><description>ObjectiveIn this report, we determine the cumulative incidence of symptomatic cardiac ischaemia and its risk factors among European 5-year childhood cancer survivors (CCS) participating in the PanCareSurFup study.MethodsEight data providers (France, Hungary, Italy (two cohorts), the Netherlands, Slovenia, Switzerland and the UK) participating in PanCareSurFup ascertained and validated symptomatic cardiac events among their 36 205 eligible CCS. Data on symptomatic cardiac ischaemia were graded according to the Criteria for Adverse Events V.3.0 (grade 3–5). We calculated cumulative incidences, both overall and for different subgroups based on treatment and malignancy, and used multivariable Cox regression to analyse risk factors.ResultsOverall, 302 out of the 36 205 CCS developed symptomatic cardiac ischaemia during follow-up (median follow-up time after primary cancer diagnosis: 23.0 years). The cumulative incidence by age 60 was 5.4% (95% CI 4.6% to 6.2%). Men (7.1% (95% CI 5.8 to 8.4)) had higher rates than women (3.4% (95% CI 2.4 to 4.4)) (p<0.0001). Of importance is that a significant number of patients (41/302) were affected as teens or young adults (14–30 years). Treatment with radiotherapy/chemotherapy conferred twofold risk (95% CI 1.5 to 3.0) and cases in these patients appeared earlier than in CCS without treatment/surgery only (15% vs 3% prior to age 30 years, respectively (p=0.04)).ConclusionsIn this very large European childhood cancer cohort, we found that by age 60 years, 1 in 18 CCS will develop a severe, life-threatening or fatal cardiac ischaemia, especially in lymphoma survivors and CCS treated with radiotherapy and chemotherapy increases the risk significantly.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2020-316655</identifier><identifier>PMID: 32826285</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Age ; Asymptomatic ; Cancer therapies ; Chemotherapy ; Childhood ; Collaboration ; Coronary artery disease ; Heart failure ; Hospitals ; Ischemia ; Life Sciences ; Medical diagnosis ; myocardial disease ; Population ; Questionnaires ; Radiation therapy ; Risk factors ; Santé publique et épidémiologie</subject><ispartof>Heart (British Cardiac Society), 2021-01, Vol.107 (1), p.33-41</ispartof><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b499t-36b33953d7769ea01ba5e0563c54c2840f45b320b114a520e550522fcafcee4f3</citedby><cites>FETCH-LOGICAL-b499t-36b33953d7769ea01ba5e0563c54c2840f45b320b114a520e550522fcafcee4f3</cites><orcidid>0000-0001-8930-3160</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32826285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-04439043$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Feijen, Elizabeth Arnoldina Maria</creatorcontrib><creatorcontrib>van Dalen, Elvira C</creatorcontrib><creatorcontrib>van der Pal, Heleen J H</creatorcontrib><creatorcontrib>Reulen, Raoul C</creatorcontrib><creatorcontrib>Winter, David L</creatorcontrib><creatorcontrib>Kuehni, Claudia E</creatorcontrib><creatorcontrib>Morsellino, Vera</creatorcontrib><creatorcontrib>Alessi, Daniela</creatorcontrib><creatorcontrib>Allodji, Rodrigue S</creatorcontrib><creatorcontrib>Byrne, Julliana</creatorcontrib><creatorcontrib>Bardi, Edit</creatorcontrib><creatorcontrib>Jakab, Zsuzsanna</creatorcontrib><creatorcontrib>Grabow, Desiree</creatorcontrib><creatorcontrib>Garwicz, Stanislaw</creatorcontrib><creatorcontrib>Haddy, Nadia</creatorcontrib><creatorcontrib>Jankovic, Momcilo</creatorcontrib><creatorcontrib>Kaatsch, Peter</creatorcontrib><creatorcontrib>Levitt, Gill A</creatorcontrib><creatorcontrib>Ronckers, Cecile M</creatorcontrib><creatorcontrib>Schindera, Christina</creatorcontrib><creatorcontrib>Skinner, Roderick</creatorcontrib><creatorcontrib>Zalatel, Lorna</creatorcontrib><creatorcontrib>Hjorth, Lars</creatorcontrib><creatorcontrib>Tissing, Wim J E</creatorcontrib><creatorcontrib>De Vathaire, Florent</creatorcontrib><creatorcontrib>Hawkins, Mike M</creatorcontrib><creatorcontrib>Kremer, Leontien C M</creatorcontrib><creatorcontrib>PanCareSurFup consortium</creatorcontrib><title>Increased risk of cardiac ischaemia in a pan-European cohort of 36 205 childhood cancer survivors: a PanCareSurFup study</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><addtitle>Heart</addtitle><description>ObjectiveIn this report, we determine the cumulative incidence of symptomatic cardiac ischaemia and its risk factors among European 5-year childhood cancer survivors (CCS) participating in the PanCareSurFup study.MethodsEight data providers (France, Hungary, Italy (two cohorts), the Netherlands, Slovenia, Switzerland and the UK) participating in PanCareSurFup ascertained and validated symptomatic cardiac events among their 36 205 eligible CCS. Data on symptomatic cardiac ischaemia were graded according to the Criteria for Adverse Events V.3.0 (grade 3–5). We calculated cumulative incidences, both overall and for different subgroups based on treatment and malignancy, and used multivariable Cox regression to analyse risk factors.ResultsOverall, 302 out of the 36 205 CCS developed symptomatic cardiac ischaemia during follow-up (median follow-up time after primary cancer diagnosis: 23.0 years). The cumulative incidence by age 60 was 5.4% (95% CI 4.6% to 6.2%). Men (7.1% (95% CI 5.8 to 8.4)) had higher rates than women (3.4% (95% CI 2.4 to 4.4)) (p<0.0001). Of importance is that a significant number of patients (41/302) were affected as teens or young adults (14–30 years). Treatment with radiotherapy/chemotherapy conferred twofold risk (95% CI 1.5 to 3.0) and cases in these patients appeared earlier than in CCS without treatment/surgery only (15% vs 3% prior to age 30 years, respectively (p=0.04)).ConclusionsIn this very large European childhood cancer cohort, we found that by age 60 years, 1 in 18 CCS will develop a severe, life-threatening or fatal cardiac ischaemia, especially in lymphoma survivors and CCS treated with radiotherapy and chemotherapy increases the risk significantly.</description><subject>Age</subject><subject>Asymptomatic</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Childhood</subject><subject>Collaboration</subject><subject>Coronary artery disease</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Ischemia</subject><subject>Life Sciences</subject><subject>Medical diagnosis</subject><subject>myocardial disease</subject><subject>Population</subject><subject>Questionnaires</subject><subject>Radiation therapy</subject><subject>Risk factors</subject><subject>Santé publique et épidémiologie</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNkV2L1DAUhoso7of-A5GAN15YN8lJMq13y7DrLgwoqOBdOE1TmrFNxqQd3H9vZrs7ghfiVUJ4npdz8hbFK0bfMwbqorcYp60fSk45LYEpJeWT4pQJVeUn9v1pvoOUpaKwOinOUtpSSkVdqefFCfCKK17J0-LXrTfRYrItiS79IKEjBmPr0BCXTI92dEicJ0h26MurOYadRU9M6EOcDjQowqkkpndD24fQZt0bG0ma497tQ0wfsvsZ_Rqj_TLH63lH0jS3dy-KZx0Oyb58OM-Lb9dXX9c35ebTx9v15aZsRF1PJagGoJbQrlaqtkhZg9JSqcBIYXglaCdkA5w2jAmUnFopqeS8M9gZa0UH58W7JbfHQe-iGzHe6YBO31xutPPJxlFTIaCmAvYs428XfBfDz9mmSY_5H-wwoLdhTpoLUFDzSsmMvvkL3YY5-rxMplQtVgD3lFgoE0NK0XbHIRjVhyL1Y5H6UKReisza64fwuRlte5Qem8vAxQI04_Z_I-kf4zjqP5XfRxm4Fg</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Feijen, Elizabeth Arnoldina Maria</creator><creator>van Dalen, Elvira C</creator><creator>van der Pal, Heleen J H</creator><creator>Reulen, Raoul C</creator><creator>Winter, David L</creator><creator>Kuehni, Claudia E</creator><creator>Morsellino, Vera</creator><creator>Alessi, Daniela</creator><creator>Allodji, Rodrigue S</creator><creator>Byrne, Julliana</creator><creator>Bardi, Edit</creator><creator>Jakab, Zsuzsanna</creator><creator>Grabow, Desiree</creator><creator>Garwicz, Stanislaw</creator><creator>Haddy, Nadia</creator><creator>Jankovic, Momcilo</creator><creator>Kaatsch, Peter</creator><creator>Levitt, Gill A</creator><creator>Ronckers, Cecile M</creator><creator>Schindera, Christina</creator><creator>Skinner, Roderick</creator><creator>Zalatel, Lorna</creator><creator>Hjorth, Lars</creator><creator>Tissing, Wim J E</creator><creator>De Vathaire, Florent</creator><creator>Hawkins, Mike M</creator><creator>Kremer, Leontien C M</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-8930-3160</orcidid></search><sort><creationdate>20210101</creationdate><title>Increased risk of cardiac ischaemia in a pan-European cohort of 36 205 childhood cancer survivors: a PanCareSurFup study</title><author>Feijen, Elizabeth Arnoldina Maria ; van Dalen, Elvira C ; van der Pal, Heleen J H ; Reulen, Raoul C ; Winter, David L ; Kuehni, Claudia E ; Morsellino, Vera ; Alessi, Daniela ; Allodji, Rodrigue S ; Byrne, Julliana ; Bardi, Edit ; Jakab, Zsuzsanna ; Grabow, Desiree ; Garwicz, Stanislaw ; Haddy, Nadia ; Jankovic, Momcilo ; Kaatsch, Peter ; Levitt, Gill A ; Ronckers, Cecile M ; Schindera, Christina ; Skinner, Roderick ; Zalatel, Lorna ; Hjorth, Lars ; Tissing, Wim J E ; De Vathaire, Florent ; Hawkins, Mike M ; Kremer, Leontien C M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b499t-36b33953d7769ea01ba5e0563c54c2840f45b320b114a520e550522fcafcee4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Asymptomatic</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Childhood</topic><topic>Collaboration</topic><topic>Coronary artery disease</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Ischemia</topic><topic>Life Sciences</topic><topic>Medical diagnosis</topic><topic>myocardial disease</topic><topic>Population</topic><topic>Questionnaires</topic><topic>Radiation therapy</topic><topic>Risk factors</topic><topic>Santé publique et épidémiologie</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feijen, Elizabeth Arnoldina Maria</creatorcontrib><creatorcontrib>van Dalen, Elvira C</creatorcontrib><creatorcontrib>van der Pal, Heleen J H</creatorcontrib><creatorcontrib>Reulen, Raoul C</creatorcontrib><creatorcontrib>Winter, David L</creatorcontrib><creatorcontrib>Kuehni, Claudia E</creatorcontrib><creatorcontrib>Morsellino, Vera</creatorcontrib><creatorcontrib>Alessi, Daniela</creatorcontrib><creatorcontrib>Allodji, Rodrigue S</creatorcontrib><creatorcontrib>Byrne, Julliana</creatorcontrib><creatorcontrib>Bardi, Edit</creatorcontrib><creatorcontrib>Jakab, Zsuzsanna</creatorcontrib><creatorcontrib>Grabow, Desiree</creatorcontrib><creatorcontrib>Garwicz, Stanislaw</creatorcontrib><creatorcontrib>Haddy, Nadia</creatorcontrib><creatorcontrib>Jankovic, Momcilo</creatorcontrib><creatorcontrib>Kaatsch, Peter</creatorcontrib><creatorcontrib>Levitt, Gill A</creatorcontrib><creatorcontrib>Ronckers, Cecile M</creatorcontrib><creatorcontrib>Schindera, Christina</creatorcontrib><creatorcontrib>Skinner, Roderick</creatorcontrib><creatorcontrib>Zalatel, Lorna</creatorcontrib><creatorcontrib>Hjorth, Lars</creatorcontrib><creatorcontrib>Tissing, Wim J E</creatorcontrib><creatorcontrib>De Vathaire, Florent</creatorcontrib><creatorcontrib>Hawkins, Mike M</creatorcontrib><creatorcontrib>Kremer, Leontien C M</creatorcontrib><creatorcontrib>PanCareSurFup consortium</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feijen, Elizabeth Arnoldina Maria</au><au>van Dalen, Elvira C</au><au>van der Pal, Heleen J H</au><au>Reulen, Raoul C</au><au>Winter, David L</au><au>Kuehni, Claudia E</au><au>Morsellino, Vera</au><au>Alessi, Daniela</au><au>Allodji, Rodrigue S</au><au>Byrne, Julliana</au><au>Bardi, Edit</au><au>Jakab, Zsuzsanna</au><au>Grabow, Desiree</au><au>Garwicz, Stanislaw</au><au>Haddy, Nadia</au><au>Jankovic, Momcilo</au><au>Kaatsch, Peter</au><au>Levitt, Gill A</au><au>Ronckers, Cecile M</au><au>Schindera, Christina</au><au>Skinner, Roderick</au><au>Zalatel, Lorna</au><au>Hjorth, Lars</au><au>Tissing, Wim J E</au><au>De Vathaire, Florent</au><au>Hawkins, Mike M</au><au>Kremer, Leontien C M</au><aucorp>PanCareSurFup consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased risk of cardiac ischaemia in a pan-European cohort of 36 205 childhood cancer survivors: a PanCareSurFup study</atitle><jtitle>Heart (British Cardiac Society)</jtitle><stitle>Heart</stitle><addtitle>Heart</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>107</volume><issue>1</issue><spage>33</spage><epage>41</epage><pages>33-41</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>ObjectiveIn this report, we determine the cumulative incidence of symptomatic cardiac ischaemia and its risk factors among European 5-year childhood cancer survivors (CCS) participating in the PanCareSurFup study.MethodsEight data providers (France, Hungary, Italy (two cohorts), the Netherlands, Slovenia, Switzerland and the UK) participating in PanCareSurFup ascertained and validated symptomatic cardiac events among their 36 205 eligible CCS. Data on symptomatic cardiac ischaemia were graded according to the Criteria for Adverse Events V.3.0 (grade 3–5). We calculated cumulative incidences, both overall and for different subgroups based on treatment and malignancy, and used multivariable Cox regression to analyse risk factors.ResultsOverall, 302 out of the 36 205 CCS developed symptomatic cardiac ischaemia during follow-up (median follow-up time after primary cancer diagnosis: 23.0 years). The cumulative incidence by age 60 was 5.4% (95% CI 4.6% to 6.2%). Men (7.1% (95% CI 5.8 to 8.4)) had higher rates than women (3.4% (95% CI 2.4 to 4.4)) (p<0.0001). Of importance is that a significant number of patients (41/302) were affected as teens or young adults (14–30 years). Treatment with radiotherapy/chemotherapy conferred twofold risk (95% CI 1.5 to 3.0) and cases in these patients appeared earlier than in CCS without treatment/surgery only (15% vs 3% prior to age 30 years, respectively (p=0.04)).ConclusionsIn this very large European childhood cancer cohort, we found that by age 60 years, 1 in 18 CCS will develop a severe, life-threatening or fatal cardiac ischaemia, especially in lymphoma survivors and CCS treated with radiotherapy and chemotherapy increases the risk significantly.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>32826285</pmid><doi>10.1136/heartjnl-2020-316655</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8930-3160</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 2021-01, Vol.107 (1), p.33-41 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_04439043v1 |
| source | PubMed Central |
| subjects | Age Asymptomatic Cancer therapies Chemotherapy Childhood Collaboration Coronary artery disease Heart failure Hospitals Ischemia Life Sciences Medical diagnosis myocardial disease Population Questionnaires Radiation therapy Risk factors Santé publique et épidémiologie |
| title | Increased risk of cardiac ischaemia in a pan-European cohort of 36 205 childhood cancer survivors: a PanCareSurFup study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T13%3A56%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20risk%20of%20cardiac%20ischaemia%20in%20a%20pan-European%20cohort%20of%2036%20205%20childhood%20cancer%20survivors:%20a%20PanCareSurFup%20study&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Feijen,%20Elizabeth%20Arnoldina%20Maria&rft.aucorp=PanCareSurFup%20consortium&rft.date=2021-01-01&rft.volume=107&rft.issue=1&rft.spage=33&rft.epage=41&rft.pages=33-41&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2020-316655&rft_dat=%3Cproquest_hal_p%3E2436392865%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2469473365&rft_id=info:pmid/32826285&rfr_iscdi=true |