Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup
Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup)...
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| Veröffentlicht in: | European journal of cancer (1990) 2019-08, Vol.117, p.71-83 |
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| creator | Allodji, Rodrigue Hawkins, Mike Bright, Chloe Fidler-Benaoudia, Miranda Winter, David Alessi, Daniela Fresneau, Brice Journy, Neige Morsellino, Vera Bárdi, Edit Bautz, Andrea Byrne, Julianne Feijen, Elizabeth Lieke Am Teepen, Jop Vu-Bezin, Giao Rubino, Carole Garwicz, Stanislaw Grabow, Desiree Gudmundsdottir, Thorgerdur Guha, Joyeeta Hau, Eva-Maria Jankovic, Momcilo Kaatsch, Peter Kaiser, Melanie Linge, Helena Muraca, Monica Llanas, Damien Veres, Cristina Øfstaas, Hilde Diallo, Ibrahima Mansouri, Imene Ronckers, Cecile Skinner, Roderick Terenziani, Monica Wesenberg, Finn Wiebe, Thomas Sacerdote, Carlotta Jakab, Zsuzsanna Haupt, Riccardo Lähteenmäki, Päivi Zaletel, Lorna Zadravec Kuehni, Claudia Winther, Jeanette Michel, Gisela Kremer, Leontien C.M. Hjorth, Lars Haddy, Nadia de Vathaire, Florent Reulen, Raoul |
| description | Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors.Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs.Conclusions: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL. |
| doi_str_mv | 10.1016/j.ejca.2019.05.013 |
| format | Article |
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We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors.Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs.Conclusions: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL.</description><identifier>ISSN: 0959-8049</identifier><identifier>DOI: 10.1016/j.ejca.2019.05.013</identifier><identifier>PMID: 31260818</identifier><language>eng</language><publisher>Elsevier</publisher><subject>Life Sciences ; Santé publique et épidémiologie</subject><ispartof>European journal of cancer (1990), 2019-08, Vol.117, p.71-83</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1597-4081 ; 0000-0002-4423-0276 ; 0000-0001-7424-6255 ; 0000-0001-6396-1018 ; 0000-0001-6496-4800 ; 0000-0002-9589-0928 ; 0000-0002-1555-8627 ; 0000-0002-3440-5108 ; 0000-0002-6192-7518 ; 0000-0002-8919-0300 ; 0000-0001-5259-7046 ; 0000-0003-3524-4657 ; 0000-0002-4853-3303 ; 0000-0001-8190-2871 ; 0000-0001-9773-0576 ; 0000-0003-0571-8460 ; 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0000-0002-1597-4081 ; 0000-0002-7328-0467 ; 0000-0001-9316-8280 ; 0000-0002-1162-675X ; 0000-0002-1895-8415 ; 0000-0002-3362-2530 ; 0000-0003-3524-4657 ; 0000-0001-9879-7051 ; 0000-0002-4423-0276 ; 0000-0001-7603-7828 ; 0000-0002-8565-0832 ; 0000-0002-8919-0300 ; 0000-0001-6811-8695 ; 0000-0002-6583-0334 ; 0000-0002-2647-2677 ; 0000-0002-6192-7518 ; 0000-0002-7879-0300 ; 0000-0001-8957-2002</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://inserm.hal.science/inserm-04434214$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Allodji, Rodrigue</creatorcontrib><creatorcontrib>Hawkins, Mike</creatorcontrib><creatorcontrib>Bright, Chloe</creatorcontrib><creatorcontrib>Fidler-Benaoudia, Miranda</creatorcontrib><creatorcontrib>Winter, David</creatorcontrib><creatorcontrib>Alessi, Daniela</creatorcontrib><creatorcontrib>Fresneau, Brice</creatorcontrib><creatorcontrib>Journy, Neige</creatorcontrib><creatorcontrib>Morsellino, Vera</creatorcontrib><creatorcontrib>Bárdi, Edit</creatorcontrib><creatorcontrib>Bautz, Andrea</creatorcontrib><creatorcontrib>Byrne, Julianne</creatorcontrib><creatorcontrib>Feijen, Elizabeth Lieke Am</creatorcontrib><creatorcontrib>Teepen, Jop</creatorcontrib><creatorcontrib>Vu-Bezin, Giao</creatorcontrib><creatorcontrib>Rubino, Carole</creatorcontrib><creatorcontrib>Garwicz, Stanislaw</creatorcontrib><creatorcontrib>Grabow, Desiree</creatorcontrib><creatorcontrib>Gudmundsdottir, Thorgerdur</creatorcontrib><creatorcontrib>Guha, Joyeeta</creatorcontrib><creatorcontrib>Hau, Eva-Maria</creatorcontrib><creatorcontrib>Jankovic, Momcilo</creatorcontrib><creatorcontrib>Kaatsch, Peter</creatorcontrib><creatorcontrib>Kaiser, Melanie</creatorcontrib><creatorcontrib>Linge, Helena</creatorcontrib><creatorcontrib>Muraca, Monica</creatorcontrib><creatorcontrib>Llanas, Damien</creatorcontrib><creatorcontrib>Veres, Cristina</creatorcontrib><creatorcontrib>Øfstaas, Hilde</creatorcontrib><creatorcontrib>Diallo, Ibrahima</creatorcontrib><creatorcontrib>Mansouri, Imene</creatorcontrib><creatorcontrib>Ronckers, Cecile</creatorcontrib><creatorcontrib>Skinner, Roderick</creatorcontrib><creatorcontrib>Terenziani, Monica</creatorcontrib><creatorcontrib>Wesenberg, Finn</creatorcontrib><creatorcontrib>Wiebe, Thomas</creatorcontrib><creatorcontrib>Sacerdote, Carlotta</creatorcontrib><creatorcontrib>Jakab, Zsuzsanna</creatorcontrib><creatorcontrib>Haupt, Riccardo</creatorcontrib><creatorcontrib>Lähteenmäki, Päivi</creatorcontrib><creatorcontrib>Zaletel, Lorna Zadravec</creatorcontrib><creatorcontrib>Kuehni, Claudia</creatorcontrib><creatorcontrib>Winther, Jeanette</creatorcontrib><creatorcontrib>Michel, Gisela</creatorcontrib><creatorcontrib>Kremer, Leontien C.M.</creatorcontrib><creatorcontrib>Hjorth, Lars</creatorcontrib><creatorcontrib>Haddy, Nadia</creatorcontrib><creatorcontrib>de Vathaire, Florent</creatorcontrib><creatorcontrib>Reulen, Raoul</creatorcontrib><title>Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup</title><title>European journal of cancer (1990)</title><description>Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors.Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs.Conclusions: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL.</description><subject>Life Sciences</subject><subject>Santé publique et épidémiologie</subject><issn>0959-8049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqVjk1OwzAQhb0A0fJzAVZzgDaMEzck7KqqVRcsELCPhmTSuE3sYsdBORD3bJF6AVZv8b736QnxKDGSKNOnfcT7kqIYZR7hIkKZXIkp5ot8nqHKJ-LW-z0iPmcKb8QkkXGKmcym4vdd-wPYGnz48vwd2PRwdLojN0LL4UDcafJAnTU7SPOZShFqPfB8ZHLnkRv0YJ3_M5SNbqvG2gpKMiU7qDTtjPVcQe1sBzJXCL2FGDEDbWAdnD3yCyyhtI11Pfg-VCP86L45t29kVuT4I7hNON6L65pazw-XvBOzzfpztZ031BaXu4UlXWyXr4U2nl1XoFKJiqUaZPJP_ARm02mx</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Allodji, Rodrigue</creator><creator>Hawkins, Mike</creator><creator>Bright, Chloe</creator><creator>Fidler-Benaoudia, Miranda</creator><creator>Winter, David</creator><creator>Alessi, 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of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup</title><author>Allodji, Rodrigue ; Hawkins, Mike ; Bright, Chloe ; Fidler-Benaoudia, Miranda ; Winter, David ; Alessi, Daniela ; Fresneau, Brice ; Journy, Neige ; Morsellino, Vera ; Bárdi, Edit ; Bautz, Andrea ; Byrne, Julianne ; Feijen, Elizabeth Lieke Am ; Teepen, Jop ; Vu-Bezin, Giao ; Rubino, Carole ; Garwicz, Stanislaw ; Grabow, Desiree ; Gudmundsdottir, Thorgerdur ; Guha, Joyeeta ; Hau, Eva-Maria ; Jankovic, Momcilo ; Kaatsch, Peter ; Kaiser, Melanie ; Linge, Helena ; Muraca, Monica ; Llanas, Damien ; Veres, Cristina ; Øfstaas, Hilde ; Diallo, Ibrahima ; Mansouri, Imene ; Ronckers, Cecile ; Skinner, Roderick ; Terenziani, Monica ; Wesenberg, Finn ; Wiebe, Thomas ; Sacerdote, Carlotta ; Jakab, Zsuzsanna ; Haupt, Riccardo ; Lähteenmäki, Päivi ; Zaletel, Lorna Zadravec ; Kuehni, Claudia ; Winther, Jeanette ; Michel, Gisela ; Kremer, Leontien C.M. ; Hjorth, Lars ; Haddy, Nadia ; de Vathaire, Florent ; Reulen, Raoul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-hal_primary_oai_HAL_inserm_04434214v13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Life Sciences</topic><topic>Santé publique et épidémiologie</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allodji, Rodrigue</creatorcontrib><creatorcontrib>Hawkins, Mike</creatorcontrib><creatorcontrib>Bright, Chloe</creatorcontrib><creatorcontrib>Fidler-Benaoudia, Miranda</creatorcontrib><creatorcontrib>Winter, David</creatorcontrib><creatorcontrib>Alessi, Daniela</creatorcontrib><creatorcontrib>Fresneau, Brice</creatorcontrib><creatorcontrib>Journy, Neige</creatorcontrib><creatorcontrib>Morsellino, Vera</creatorcontrib><creatorcontrib>Bárdi, Edit</creatorcontrib><creatorcontrib>Bautz, Andrea</creatorcontrib><creatorcontrib>Byrne, Julianne</creatorcontrib><creatorcontrib>Feijen, Elizabeth Lieke Am</creatorcontrib><creatorcontrib>Teepen, Jop</creatorcontrib><creatorcontrib>Vu-Bezin, Giao</creatorcontrib><creatorcontrib>Rubino, Carole</creatorcontrib><creatorcontrib>Garwicz, Stanislaw</creatorcontrib><creatorcontrib>Grabow, Desiree</creatorcontrib><creatorcontrib>Gudmundsdottir, Thorgerdur</creatorcontrib><creatorcontrib>Guha, Joyeeta</creatorcontrib><creatorcontrib>Hau, Eva-Maria</creatorcontrib><creatorcontrib>Jankovic, Momcilo</creatorcontrib><creatorcontrib>Kaatsch, Peter</creatorcontrib><creatorcontrib>Kaiser, Melanie</creatorcontrib><creatorcontrib>Linge, Helena</creatorcontrib><creatorcontrib>Muraca, Monica</creatorcontrib><creatorcontrib>Llanas, Damien</creatorcontrib><creatorcontrib>Veres, Cristina</creatorcontrib><creatorcontrib>Øfstaas, Hilde</creatorcontrib><creatorcontrib>Diallo, Ibrahima</creatorcontrib><creatorcontrib>Mansouri, Imene</creatorcontrib><creatorcontrib>Ronckers, Cecile</creatorcontrib><creatorcontrib>Skinner, Roderick</creatorcontrib><creatorcontrib>Terenziani, Monica</creatorcontrib><creatorcontrib>Wesenberg, Finn</creatorcontrib><creatorcontrib>Wiebe, Thomas</creatorcontrib><creatorcontrib>Sacerdote, Carlotta</creatorcontrib><creatorcontrib>Jakab, Zsuzsanna</creatorcontrib><creatorcontrib>Haupt, Riccardo</creatorcontrib><creatorcontrib>Lähteenmäki, Päivi</creatorcontrib><creatorcontrib>Zaletel, Lorna Zadravec</creatorcontrib><creatorcontrib>Kuehni, Claudia</creatorcontrib><creatorcontrib>Winther, Jeanette</creatorcontrib><creatorcontrib>Michel, Gisela</creatorcontrib><creatorcontrib>Kremer, Leontien C.M.</creatorcontrib><creatorcontrib>Hjorth, Lars</creatorcontrib><creatorcontrib>Haddy, Nadia</creatorcontrib><creatorcontrib>de Vathaire, Florent</creatorcontrib><creatorcontrib>Reulen, Raoul</creatorcontrib><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allodji, Rodrigue</au><au>Hawkins, Mike</au><au>Bright, Chloe</au><au>Fidler-Benaoudia, Miranda</au><au>Winter, David</au><au>Alessi, Daniela</au><au>Fresneau, Brice</au><au>Journy, Neige</au><au>Morsellino, Vera</au><au>Bárdi, Edit</au><au>Bautz, Andrea</au><au>Byrne, Julianne</au><au>Feijen, Elizabeth Lieke Am</au><au>Teepen, Jop</au><au>Vu-Bezin, Giao</au><au>Rubino, Carole</au><au>Garwicz, Stanislaw</au><au>Grabow, Desiree</au><au>Gudmundsdottir, Thorgerdur</au><au>Guha, Joyeeta</au><au>Hau, Eva-Maria</au><au>Jankovic, Momcilo</au><au>Kaatsch, Peter</au><au>Kaiser, Melanie</au><au>Linge, Helena</au><au>Muraca, Monica</au><au>Llanas, Damien</au><au>Veres, Cristina</au><au>Øfstaas, Hilde</au><au>Diallo, Ibrahima</au><au>Mansouri, Imene</au><au>Ronckers, Cecile</au><au>Skinner, Roderick</au><au>Terenziani, Monica</au><au>Wesenberg, Finn</au><au>Wiebe, Thomas</au><au>Sacerdote, Carlotta</au><au>Jakab, Zsuzsanna</au><au>Haupt, Riccardo</au><au>Lähteenmäki, Päivi</au><au>Zaletel, Lorna Zadravec</au><au>Kuehni, Claudia</au><au>Winther, Jeanette</au><au>Michel, Gisela</au><au>Kremer, Leontien C.M.</au><au>Hjorth, Lars</au><au>Haddy, Nadia</au><au>de Vathaire, Florent</au><au>Reulen, Raoul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup</atitle><jtitle>European journal of cancer (1990)</jtitle><date>2019-08</date><risdate>2019</risdate><volume>117</volume><spage>71</spage><epage>83</epage><pages>71-83</pages><issn>0959-8049</issn><abstract>Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors.Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs.Conclusions: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL.</abstract><pub>Elsevier</pub><pmid>31260818</pmid><doi>10.1016/j.ejca.2019.05.013</doi><orcidid>https://orcid.org/0000-0002-1597-4081</orcidid><orcidid>https://orcid.org/0000-0002-4423-0276</orcidid><orcidid>https://orcid.org/0000-0001-7424-6255</orcidid><orcidid>https://orcid.org/0000-0001-6396-1018</orcidid><orcidid>https://orcid.org/0000-0001-6496-4800</orcidid><orcidid>https://orcid.org/0000-0002-9589-0928</orcidid><orcidid>https://orcid.org/0000-0002-1555-8627</orcidid><orcidid>https://orcid.org/0000-0002-3440-5108</orcidid><orcidid>https://orcid.org/0000-0002-6192-7518</orcidid><orcidid>https://orcid.org/0000-0002-8919-0300</orcidid><orcidid>https://orcid.org/0000-0001-5259-7046</orcidid><orcidid>https://orcid.org/0000-0003-3524-4657</orcidid><orcidid>https://orcid.org/0000-0002-4853-3303</orcidid><orcidid>https://orcid.org/0000-0001-8190-2871</orcidid><orcidid>https://orcid.org/0000-0001-9773-0576</orcidid><orcidid>https://orcid.org/0000-0003-0571-8460</orcidid><orcidid>https://orcid.org/0000-0002-3362-2530</orcidid><orcidid>https://orcid.org/0000-0002-8008-5096</orcidid><orcidid>https://orcid.org/0000-0002-5500-9606</orcidid><orcidid>https://orcid.org/0000-0001-7603-7828</orcidid><orcidid>https://orcid.org/0000-0001-8957-2002</orcidid><orcidid>https://orcid.org/0000-0002-2647-2677</orcidid><orcidid>https://orcid.org/0000-0001-9879-7051</orcidid><orcidid>https://orcid.org/0000-0002-1070-3004</orcidid><orcidid>https://orcid.org/0000-0002-7080-6718</orcidid><orcidid>https://orcid.org/0000-0002-9553-0527</orcidid><orcidid>https://orcid.org/0000-0002-6583-0334</orcidid><orcidid>https://orcid.org/0000-0002-8302-7174</orcidid><orcidid>https://orcid.org/0000-0001-9594-9881</orcidid><orcidid>https://orcid.org/0000-0002-8272-8817</orcidid><orcidid>https://orcid.org/0000-0002-7567-9076</orcidid><orcidid>https://orcid.org/0000-0002-9850-3495</orcidid><orcidid>https://orcid.org/0000-0001-6811-8695</orcidid><orcidid>https://orcid.org/0000-0002-7328-0467</orcidid><orcidid>https://orcid.org/0000-0002-1895-8415</orcidid><orcidid>https://orcid.org/0000-0002-7879-0300</orcidid><orcidid>https://orcid.org/0000-0002-1162-675X</orcidid><orcidid>https://orcid.org/0000-0001-9316-8280</orcidid><orcidid>https://orcid.org/0000-0002-8565-0832</orcidid><orcidid>https://orcid.org/0000-0002-8374-9281</orcidid><orcidid>https://orcid.org/0000-0002-8272-8817</orcidid><orcidid>https://orcid.org/0000-0001-5259-7046</orcidid><orcidid>https://orcid.org/0000-0003-0571-8460</orcidid><orcidid>https://orcid.org/0000-0001-8190-2871</orcidid><orcidid>https://orcid.org/0000-0002-9850-3495</orcidid><orcidid>https://orcid.org/0000-0002-4853-3303</orcidid><orcidid>https://orcid.org/0000-0002-7080-6718</orcidid><orcidid>https://orcid.org/0000-0002-1070-3004</orcidid><orcidid>https://orcid.org/0000-0001-9594-9881</orcidid><orcidid>https://orcid.org/0000-0002-7567-9076</orcidid><orcidid>https://orcid.org/0000-0002-1555-8627</orcidid><orcidid>https://orcid.org/0000-0002-8374-9281</orcidid><orcidid>https://orcid.org/0000-0001-7424-6255</orcidid><orcidid>https://orcid.org/0000-0002-5500-9606</orcidid><orcidid>https://orcid.org/0000-0002-8008-5096</orcidid><orcidid>https://orcid.org/0000-0002-3440-5108</orcidid><orcidid>https://orcid.org/0000-0001-9773-0576</orcidid><orcidid>https://orcid.org/0000-0002-9589-0928</orcidid><orcidid>https://orcid.org/0000-0002-8302-7174</orcidid><orcidid>https://orcid.org/0000-0002-9553-0527</orcidid><orcidid>https://orcid.org/0000-0001-6496-4800</orcidid><orcidid>https://orcid.org/0000-0001-6396-1018</orcidid><orcidid>https://orcid.org/0000-0002-1597-4081</orcidid><orcidid>https://orcid.org/0000-0002-7328-0467</orcidid><orcidid>https://orcid.org/0000-0001-9316-8280</orcidid><orcidid>https://orcid.org/0000-0002-1162-675X</orcidid><orcidid>https://orcid.org/0000-0002-1895-8415</orcidid><orcidid>https://orcid.org/0000-0002-3362-2530</orcidid><orcidid>https://orcid.org/0000-0003-3524-4657</orcidid><orcidid>https://orcid.org/0000-0001-9879-7051</orcidid><orcidid>https://orcid.org/0000-0002-4423-0276</orcidid><orcidid>https://orcid.org/0000-0001-7603-7828</orcidid><orcidid>https://orcid.org/0000-0002-8565-0832</orcidid><orcidid>https://orcid.org/0000-0002-8919-0300</orcidid><orcidid>https://orcid.org/0000-0001-6811-8695</orcidid><orcidid>https://orcid.org/0000-0002-6583-0334</orcidid><orcidid>https://orcid.org/0000-0002-2647-2677</orcidid><orcidid>https://orcid.org/0000-0002-6192-7518</orcidid><orcidid>https://orcid.org/0000-0002-7879-0300</orcidid><orcidid>https://orcid.org/0000-0001-8957-2002</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 2019-08, Vol.117, p.71-83 |
| issn | 0959-8049 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_04434214v1 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Life Sciences Santé publique et épidémiologie |
| title | Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup |
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