A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death

Apoptosis triggered by endoplasmic reticulum (ER) stress has been implicated in many diseases but its cellular regulation remains poorly understood. Previously, we identified salubrinal (sal), a small molecule that protects cells from ER stress-induced apoptosis by selectively activating a subset of...

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Veröffentlicht in:	Cell death and differentiation 2008-03, Vol.15 (3), p.589-599
Hauptverfasser:	Boyce, M, Py, B F, Ryazanov, A G, Minden, J S, Long, K, Ma, D, Yuan, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cells, Cultured Cinnamates - pharmacology Elongation Factor 2 Kinase - metabolism Endoplasmic Reticulum - metabolism Eukaryotic Initiation Factor-2 - metabolism Life Sciences Mice original-paper PC12 Cells Peptide Elongation Factor 2 - metabolism Proteomics Rats Signal Transduction Stem Cells Thiourea - analogs & derivatives Thiourea - pharmacology
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