Right ventricular function and iron deficiency in acute heart failure
Iron deficiency (ID) is a frequent finding in patients with chronic and acute heart failure (AHF) along the full spectrum of left ventricular ejection fraction (LVEF). Iron deficiency has been related to ventricular systolic dysfunction, but its role in right ventricular function has not been evalua...
Gespeichert in:
| Veröffentlicht in: | European heart journal. Acute cardiovascular care 2021-04, Vol.10 (4), p.406-414 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 414 |
|---|---|
| container_issue | 4 |
| container_start_page | 406 |
| container_title | European heart journal. Acute cardiovascular care |
| container_volume | 10 |
| creator | Miñana, Gema Santas, Enrique de la Espriella, Rafael Núñez, Eduardo Lorenzo, Miguel Núñez, Gonzalo Valero, Ernesto Bodí, Vicent Chorro, Francisco J Sanchis, Juan Cohen-Solal, Alain Bayés-Genís, Antoni Núñez, Julio |
| description | Iron deficiency (ID) is a frequent finding in patients with chronic and acute heart failure (AHF) along the full spectrum of left ventricular ejection fraction (LVEF). Iron deficiency has been related to ventricular systolic dysfunction, but its role in right ventricular function has not been evaluated. We sought to evaluate whether ID identifies patients with greater right ventricular dysfunction in the setting of AHF.
We prospectively included 903 patients admitted with AHF. Right systolic function was evaluated by tricuspid annular plane systolic excursion (TAPSE) and the ratio TAPSE/pulmonary artery systolic pressure (TAPSE/PASP). Iron deficiency was defined, according to European Society of Cardiology criteria, as serum ferritin |
| doi_str_mv | 10.1093/ehjacc/zuaa028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_inserm_03934955v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2492660338</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-d04c9c5677ecf398096e3cdeee5aca3505a7ff0b809adf86ab8c6e9cba4b035c3</originalsourceid><addsrcrecordid>eNo9kEFPwkAQhTdGIwS5ejQ9erCwdLvb7ZEQFBMSE6PnzXQ6K0tKi7stCf56a0DmMi_zvnmHx9j9jE9mPBdT2mwBcfrTAfBEX7FhwlMd60yk1xedqAEbh7Dl_WRcpVrcsoEQqrelHLLlu_vatNGB6tY77Crwke1qbF1TR1CXkfO9KMk6dFTjMXL9GbuWog2BbyMLruo83bEbC1Wg8XmP2Ofz8mOxitdvL6-L-TrGVOg2LnmKOUqVZYRW5JrnigSWRCQBQUguIbOWF70BpdUKCo2KciwgLbiQKEbs6ZS7gcrsvduBP5oGnFnN18bVgfzOcJGLNJfyMOvxxxO-9813R6E1OxeQqgpqarpgkjRPlOJC6B6dnFD0TQie7CV-xs1f2eZUtjmX3T88nLO7YkflBf-vVvwCGXx9Ww</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2492660338</pqid></control><display><type>article</type><title>Right ventricular function and iron deficiency in acute heart failure</title><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Miñana, Gema ; Santas, Enrique ; de la Espriella, Rafael ; Núñez, Eduardo ; Lorenzo, Miguel ; Núñez, Gonzalo ; Valero, Ernesto ; Bodí, Vicent ; Chorro, Francisco J ; Sanchis, Juan ; Cohen-Solal, Alain ; Bayés-Genís, Antoni ; Núñez, Julio</creator><creatorcontrib>Miñana, Gema ; Santas, Enrique ; de la Espriella, Rafael ; Núñez, Eduardo ; Lorenzo, Miguel ; Núñez, Gonzalo ; Valero, Ernesto ; Bodí, Vicent ; Chorro, Francisco J ; Sanchis, Juan ; Cohen-Solal, Alain ; Bayés-Genís, Antoni ; Núñez, Julio</creatorcontrib><description>Iron deficiency (ID) is a frequent finding in patients with chronic and acute heart failure (AHF) along the full spectrum of left ventricular ejection fraction (LVEF). Iron deficiency has been related to ventricular systolic dysfunction, but its role in right ventricular function has not been evaluated. We sought to evaluate whether ID identifies patients with greater right ventricular dysfunction in the setting of AHF.
We prospectively included 903 patients admitted with AHF. Right systolic function was evaluated by tricuspid annular plane systolic excursion (TAPSE) and the ratio TAPSE/pulmonary artery systolic pressure (TAPSE/PASP). Iron deficiency was defined, according to European Society of Cardiology criteria, as serum ferritin <100 mg/dL (absolute ID) or ferritin 100-299 mg/dL and transferrin saturation (TSAT) <20% (functional ID). The relationships among the exposures with right ventricular systolic function were evaluated by multivariate linear regression analyses. The mean age of the sample was 74.3 ± 10.6 years, 441 (48.8%) were female, 471 (52.2%) exhibited heart failure with preserved ejection fraction, and 677 (75.0%) showed ID. The mean LVEF, TAPSE, and TAPSE/PASP were 49 ± 15%, 18.6 ± 3.9 mm, and 0.45 ± 0.18, respectively. The median (interquartile range) amino-terminal pro-brain natriuretic peptide was 4015 (1807-8775) pg/mL. In a multivariable setting, lower TSAT and ferritin were independently associated with lower TAPSE (P < 0.05 for both comparisons). Transferrin saturation (P = 0.017), and not ferritin (P = 0.633), was independently associated with TAPSE/PASP.
In AHF, proxies of ID were associated with right ventricular dysfunction. Further studies should confirm these findings and evaluate the pathophysiological facts behind this association.</description><identifier>ISSN: 2048-8726</identifier><identifier>EISSN: 2048-8734</identifier><identifier>DOI: 10.1093/ehjacc/zuaa028</identifier><identifier>PMID: 33620455</identifier><language>eng</language><publisher>England: SAGE Publications</publisher><subject>Cardiology and cardiovascular system ; Human health and pathology ; Life Sciences</subject><ispartof>European heart journal. Acute cardiovascular care, 2021-04, Vol.10 (4), p.406-414</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-d04c9c5677ecf398096e3cdeee5aca3505a7ff0b809adf86ab8c6e9cba4b035c3</citedby><cites>FETCH-LOGICAL-c438t-d04c9c5677ecf398096e3cdeee5aca3505a7ff0b809adf86ab8c6e9cba4b035c3</cites><orcidid>0000-0003-1672-7119 ; 0000-0001-8777-2588</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33620455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-03934955$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Miñana, Gema</creatorcontrib><creatorcontrib>Santas, Enrique</creatorcontrib><creatorcontrib>de la Espriella, Rafael</creatorcontrib><creatorcontrib>Núñez, Eduardo</creatorcontrib><creatorcontrib>Lorenzo, Miguel</creatorcontrib><creatorcontrib>Núñez, Gonzalo</creatorcontrib><creatorcontrib>Valero, Ernesto</creatorcontrib><creatorcontrib>Bodí, Vicent</creatorcontrib><creatorcontrib>Chorro, Francisco J</creatorcontrib><creatorcontrib>Sanchis, Juan</creatorcontrib><creatorcontrib>Cohen-Solal, Alain</creatorcontrib><creatorcontrib>Bayés-Genís, Antoni</creatorcontrib><creatorcontrib>Núñez, Julio</creatorcontrib><title>Right ventricular function and iron deficiency in acute heart failure</title><title>European heart journal. Acute cardiovascular care</title><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><description>Iron deficiency (ID) is a frequent finding in patients with chronic and acute heart failure (AHF) along the full spectrum of left ventricular ejection fraction (LVEF). Iron deficiency has been related to ventricular systolic dysfunction, but its role in right ventricular function has not been evaluated. We sought to evaluate whether ID identifies patients with greater right ventricular dysfunction in the setting of AHF.
We prospectively included 903 patients admitted with AHF. Right systolic function was evaluated by tricuspid annular plane systolic excursion (TAPSE) and the ratio TAPSE/pulmonary artery systolic pressure (TAPSE/PASP). Iron deficiency was defined, according to European Society of Cardiology criteria, as serum ferritin <100 mg/dL (absolute ID) or ferritin 100-299 mg/dL and transferrin saturation (TSAT) <20% (functional ID). The relationships among the exposures with right ventricular systolic function were evaluated by multivariate linear regression analyses. The mean age of the sample was 74.3 ± 10.6 years, 441 (48.8%) were female, 471 (52.2%) exhibited heart failure with preserved ejection fraction, and 677 (75.0%) showed ID. The mean LVEF, TAPSE, and TAPSE/PASP were 49 ± 15%, 18.6 ± 3.9 mm, and 0.45 ± 0.18, respectively. The median (interquartile range) amino-terminal pro-brain natriuretic peptide was 4015 (1807-8775) pg/mL. In a multivariable setting, lower TSAT and ferritin were independently associated with lower TAPSE (P < 0.05 for both comparisons). Transferrin saturation (P = 0.017), and not ferritin (P = 0.633), was independently associated with TAPSE/PASP.
In AHF, proxies of ID were associated with right ventricular dysfunction. Further studies should confirm these findings and evaluate the pathophysiological facts behind this association.</description><subject>Cardiology and cardiovascular system</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><issn>2048-8726</issn><issn>2048-8734</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9kEFPwkAQhTdGIwS5ejQ9erCwdLvb7ZEQFBMSE6PnzXQ6K0tKi7stCf56a0DmMi_zvnmHx9j9jE9mPBdT2mwBcfrTAfBEX7FhwlMd60yk1xedqAEbh7Dl_WRcpVrcsoEQqrelHLLlu_vatNGB6tY77Crwke1qbF1TR1CXkfO9KMk6dFTjMXL9GbuWog2BbyMLruo83bEbC1Wg8XmP2Ofz8mOxitdvL6-L-TrGVOg2LnmKOUqVZYRW5JrnigSWRCQBQUguIbOWF70BpdUKCo2KciwgLbiQKEbs6ZS7gcrsvduBP5oGnFnN18bVgfzOcJGLNJfyMOvxxxO-9813R6E1OxeQqgpqarpgkjRPlOJC6B6dnFD0TQie7CV-xs1f2eZUtjmX3T88nLO7YkflBf-vVvwCGXx9Ww</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Miñana, Gema</creator><creator>Santas, Enrique</creator><creator>de la Espriella, Rafael</creator><creator>Núñez, Eduardo</creator><creator>Lorenzo, Miguel</creator><creator>Núñez, Gonzalo</creator><creator>Valero, Ernesto</creator><creator>Bodí, Vicent</creator><creator>Chorro, Francisco J</creator><creator>Sanchis, Juan</creator><creator>Cohen-Solal, Alain</creator><creator>Bayés-Genís, Antoni</creator><creator>Núñez, Julio</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1672-7119</orcidid><orcidid>https://orcid.org/0000-0001-8777-2588</orcidid></search><sort><creationdate>20210401</creationdate><title>Right ventricular function and iron deficiency in acute heart failure</title><author>Miñana, Gema ; Santas, Enrique ; de la Espriella, Rafael ; Núñez, Eduardo ; Lorenzo, Miguel ; Núñez, Gonzalo ; Valero, Ernesto ; Bodí, Vicent ; Chorro, Francisco J ; Sanchis, Juan ; Cohen-Solal, Alain ; Bayés-Genís, Antoni ; Núñez, Julio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-d04c9c5677ecf398096e3cdeee5aca3505a7ff0b809adf86ab8c6e9cba4b035c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiology and cardiovascular system</topic><topic>Human health and pathology</topic><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miñana, Gema</creatorcontrib><creatorcontrib>Santas, Enrique</creatorcontrib><creatorcontrib>de la Espriella, Rafael</creatorcontrib><creatorcontrib>Núñez, Eduardo</creatorcontrib><creatorcontrib>Lorenzo, Miguel</creatorcontrib><creatorcontrib>Núñez, Gonzalo</creatorcontrib><creatorcontrib>Valero, Ernesto</creatorcontrib><creatorcontrib>Bodí, Vicent</creatorcontrib><creatorcontrib>Chorro, Francisco J</creatorcontrib><creatorcontrib>Sanchis, Juan</creatorcontrib><creatorcontrib>Cohen-Solal, Alain</creatorcontrib><creatorcontrib>Bayés-Genís, Antoni</creatorcontrib><creatorcontrib>Núñez, Julio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European heart journal. Acute cardiovascular care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miñana, Gema</au><au>Santas, Enrique</au><au>de la Espriella, Rafael</au><au>Núñez, Eduardo</au><au>Lorenzo, Miguel</au><au>Núñez, Gonzalo</au><au>Valero, Ernesto</au><au>Bodí, Vicent</au><au>Chorro, Francisco J</au><au>Sanchis, Juan</au><au>Cohen-Solal, Alain</au><au>Bayés-Genís, Antoni</au><au>Núñez, Julio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right ventricular function and iron deficiency in acute heart failure</atitle><jtitle>European heart journal. Acute cardiovascular care</jtitle><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>10</volume><issue>4</issue><spage>406</spage><epage>414</epage><pages>406-414</pages><issn>2048-8726</issn><eissn>2048-8734</eissn><abstract>Iron deficiency (ID) is a frequent finding in patients with chronic and acute heart failure (AHF) along the full spectrum of left ventricular ejection fraction (LVEF). Iron deficiency has been related to ventricular systolic dysfunction, but its role in right ventricular function has not been evaluated. We sought to evaluate whether ID identifies patients with greater right ventricular dysfunction in the setting of AHF.
We prospectively included 903 patients admitted with AHF. Right systolic function was evaluated by tricuspid annular plane systolic excursion (TAPSE) and the ratio TAPSE/pulmonary artery systolic pressure (TAPSE/PASP). Iron deficiency was defined, according to European Society of Cardiology criteria, as serum ferritin <100 mg/dL (absolute ID) or ferritin 100-299 mg/dL and transferrin saturation (TSAT) <20% (functional ID). The relationships among the exposures with right ventricular systolic function were evaluated by multivariate linear regression analyses. The mean age of the sample was 74.3 ± 10.6 years, 441 (48.8%) were female, 471 (52.2%) exhibited heart failure with preserved ejection fraction, and 677 (75.0%) showed ID. The mean LVEF, TAPSE, and TAPSE/PASP were 49 ± 15%, 18.6 ± 3.9 mm, and 0.45 ± 0.18, respectively. The median (interquartile range) amino-terminal pro-brain natriuretic peptide was 4015 (1807-8775) pg/mL. In a multivariable setting, lower TSAT and ferritin were independently associated with lower TAPSE (P < 0.05 for both comparisons). Transferrin saturation (P = 0.017), and not ferritin (P = 0.633), was independently associated with TAPSE/PASP.
In AHF, proxies of ID were associated with right ventricular dysfunction. Further studies should confirm these findings and evaluate the pathophysiological facts behind this association.</abstract><cop>England</cop><pub>SAGE Publications</pub><pmid>33620455</pmid><doi>10.1093/ehjacc/zuaa028</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1672-7119</orcidid><orcidid>https://orcid.org/0000-0001-8777-2588</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2048-8726 |
| ispartof | European heart journal. Acute cardiovascular care, 2021-04, Vol.10 (4), p.406-414 |
| issn | 2048-8726 2048-8734 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_03934955v1 |
| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Cardiology and cardiovascular system Human health and pathology Life Sciences |
| title | Right ventricular function and iron deficiency in acute heart failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T06%3A10%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Right%20ventricular%20function%20and%20iron%20deficiency%20in%20acute%20heart%20failure&rft.jtitle=European%20heart%20journal.%20Acute%20cardiovascular%20care&rft.au=Mi%C3%B1ana,%20Gema&rft.date=2021-04-01&rft.volume=10&rft.issue=4&rft.spage=406&rft.epage=414&rft.pages=406-414&rft.issn=2048-8726&rft.eissn=2048-8734&rft_id=info:doi/10.1093/ehjacc/zuaa028&rft_dat=%3Cproquest_hal_p%3E2492660338%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2492660338&rft_id=info:pmid/33620455&rfr_iscdi=true |