Meta-analyses frequently include old trials that are associated with a larger intervention effect: a meta-epidemiological study

•Trials published before 2000 represented one fourth of all trials included in meta-analyses and trials published before 1990 almost 10%. The oldest trial was published in 1951.•Intervention effects were, on average, significantly larger for older than recent trials.•Results were consistent in sensi...

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Veröffentlicht in:	Journal of clinical epidemiology 2022-05, Vol.145, p.144-153
Hauptverfasser:	Smail-Faugeron, Violaine, Tan, Aidan, Caille, Agnès, Yordanov, Youri, Hajage, David, Tubach, Florence, Martin, Guillaume, Dechartres, Agnès
Format:	Artikel
Sprache:	eng
Schlagworte:	Bias Clinical medicine Confidence intervals Epidemiology Estimates External validity Intervention Life Sciences Meta-analysis Meta-epidemiology Publication date Systematic review
Online-Zugang:	Volltext
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