A re‐examination of antidepressant treatment‐emergent mania in bipolar disorders: evidence of gender differences
Objective To explore the prevalence and clinical profile of males and females who develop antidepressant treatment‐emergent mania (ATEM). Method From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM‐ controls (n = 135) that met stringent criteria. We specifical...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2017-05, Vol.135 (5), p.479-488 |
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| container_title | Acta psychiatrica Scandinavica |
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| creator | Scott, J. Brichant‐Petitjean, C. Etain, B. Henry, C. Kahn, J.‐P. Azorin, J.‐M. Leboyer, M. Bellivier, F. |
| description | Objective
To explore the prevalence and clinical profile of males and females who develop antidepressant treatment‐emergent mania (ATEM).
Method
From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM‐ controls (n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases.
Results
Seventy‐five individuals were classified as ATEM+; 87% of ATEM events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and/or substance use disorder [Odds Ratio (OR) 6.37], a history of one or more suicide attempts (OR 4.19) and higher number of depressive episodes per year of illness (OR 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder (OR 3.23), a positive family history of BD I (OR 2.68) and depressive onset polarity (OR 2.01).
Conclusion
Using stringent definitions of ATEM status to reduce the probability of inclusion of false‐positive cases and false‐negative controls, we identified for the first time that the risk profiles for the development of an ATEM differ significantly according to gender. |
| doi_str_mv | 10.1111/acps.12728 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_inserm_03854505v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1884167535</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4278-81ab34393b0780abc07157e459e894058f7dcbb2eb6576863c6ae4916c4334e13</originalsourceid><addsrcrecordid>eNqN0c1qFTEYBuAgij1WN16ABNxIcWoy-Xd3OFQrHFBQwV3IZL7RlJnMmMypducleI1eiZlO7cKFmE3-nrxJ-BB6TMkpLe2F81M-pbWq9R20oZKQinCu7qINIYRW0pBPR-hBzhdlKijR99FRrZk0ipgNmrc4wa8fP-G7G0J0cxgjHjvs4hxamBLkXIZ4TuDmAeK8yAHS5zLEg4vB4RBxE6axdwm3IY-phZRfYrgsx6OHJavgslh2uw7Sspgfonud6zM8uumP0cdXZx9259X-7es3u-2-8rxWutLUNYwzwxqiNHGNJ4oKBVwY0IYToTvV-qapoZFCSS2Zlw64odJzxjhQdoyer7lfXG-nFAaXruzogj3f7m2IGdJgCdOCCyIuF_5s5VMavx4gz3YI2UPfuwjjIVuqDdWKl7v-g2pOpRJMFPr0L3oxHlIs_75WzIha1kWdrMqnMecE3e17KbFLle1SZXtd5YKf3EQemgHaW_qnrAXQFXwLPVz9I8pud-_er6G_AeI8s1I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1884395262</pqid></control><display><type>article</type><title>A re‐examination of antidepressant treatment‐emergent mania in bipolar disorders: evidence of gender differences</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Scott, J. ; Brichant‐Petitjean, C. ; Etain, B. ; Henry, C. ; Kahn, J.‐P. ; Azorin, J.‐M. ; Leboyer, M. ; Bellivier, F.</creator><creatorcontrib>Scott, J. ; Brichant‐Petitjean, C. ; Etain, B. ; Henry, C. ; Kahn, J.‐P. ; Azorin, J.‐M. ; Leboyer, M. ; Bellivier, F.</creatorcontrib><description>Objective
To explore the prevalence and clinical profile of males and females who develop antidepressant treatment‐emergent mania (ATEM).
Method
From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM‐ controls (n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases.
Results
Seventy‐five individuals were classified as ATEM+; 87% of ATEM events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and/or substance use disorder [Odds Ratio (OR) 6.37], a history of one or more suicide attempts (OR 4.19) and higher number of depressive episodes per year of illness (OR 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder (OR 3.23), a positive family history of BD I (OR 2.68) and depressive onset polarity (OR 2.01).
Conclusion
Using stringent definitions of ATEM status to reduce the probability of inclusion of false‐positive cases and false‐negative controls, we identified for the first time that the risk profiles for the development of an ATEM differ significantly according to gender.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/acps.12728</identifier><identifier>PMID: 28369709</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; antidepressant treatment‐emergent mania ; Antidepressants ; antidepressant‐induced mania ; Antidepressive Agents ; Antidepressive Agents - adverse effects ; Antidepressive Agents - therapeutic use ; Bipolar Disorder ; Bipolar Disorder - drug therapy ; Bipolar Disorder - psychology ; clinical predictors ; depression ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; gender ; Gender differences ; Health risk assessment ; Human health and pathology ; Humans ; Life Sciences ; Male ; Psychiatric Status Rating Scales ; Psychiatrics and mental health ; Psychopharmacology ; Regression Analysis ; Sex Characteristics ; thyroid disease ; treatment‐emergent affective switch ; Young Adult</subject><ispartof>Acta psychiatrica Scandinavica, 2017-05, Vol.135 (5), p.479-488</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2017 John Wiley & Sons A/S, Published by John Wiley & Sons Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4278-81ab34393b0780abc07157e459e894058f7dcbb2eb6576863c6ae4916c4334e13</citedby><cites>FETCH-LOGICAL-c4278-81ab34393b0780abc07157e459e894058f7dcbb2eb6576863c6ae4916c4334e13</cites><orcidid>0000-0002-5377-1488 ; 0000-0002-3660-6640 ; 0000-0002-7203-8601 ; 0000-0001-5473-3697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facps.12728$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facps.12728$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28369709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-03854505$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott, J.</creatorcontrib><creatorcontrib>Brichant‐Petitjean, C.</creatorcontrib><creatorcontrib>Etain, B.</creatorcontrib><creatorcontrib>Henry, C.</creatorcontrib><creatorcontrib>Kahn, J.‐P.</creatorcontrib><creatorcontrib>Azorin, J.‐M.</creatorcontrib><creatorcontrib>Leboyer, M.</creatorcontrib><creatorcontrib>Bellivier, F.</creatorcontrib><title>A re‐examination of antidepressant treatment‐emergent mania in bipolar disorders: evidence of gender differences</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective
To explore the prevalence and clinical profile of males and females who develop antidepressant treatment‐emergent mania (ATEM).
Method
From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM‐ controls (n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases.
Results
Seventy‐five individuals were classified as ATEM+; 87% of ATEM events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and/or substance use disorder [Odds Ratio (OR) 6.37], a history of one or more suicide attempts (OR 4.19) and higher number of depressive episodes per year of illness (OR 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder (OR 3.23), a positive family history of BD I (OR 2.68) and depressive onset polarity (OR 2.01).
Conclusion
Using stringent definitions of ATEM status to reduce the probability of inclusion of false‐positive cases and false‐negative controls, we identified for the first time that the risk profiles for the development of an ATEM differ significantly according to gender.</description><subject>Adolescent</subject><subject>Adult</subject><subject>antidepressant treatment‐emergent mania</subject><subject>Antidepressants</subject><subject>antidepressant‐induced mania</subject><subject>Antidepressive Agents</subject><subject>Antidepressive Agents - adverse effects</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Bipolar Disorder</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - psychology</subject><subject>clinical predictors</subject><subject>depression</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Female</subject><subject>gender</subject><subject>Gender differences</subject><subject>Health risk assessment</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatrics and mental health</subject><subject>Psychopharmacology</subject><subject>Regression Analysis</subject><subject>Sex Characteristics</subject><subject>thyroid disease</subject><subject>treatment‐emergent affective switch</subject><subject>Young Adult</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c1qFTEYBuAgij1WN16ABNxIcWoy-Xd3OFQrHFBQwV3IZL7RlJnMmMypducleI1eiZlO7cKFmE3-nrxJ-BB6TMkpLe2F81M-pbWq9R20oZKQinCu7qINIYRW0pBPR-hBzhdlKijR99FRrZk0ipgNmrc4wa8fP-G7G0J0cxgjHjvs4hxamBLkXIZ4TuDmAeK8yAHS5zLEg4vB4RBxE6axdwm3IY-phZRfYrgsx6OHJavgslh2uw7Sspgfonud6zM8uumP0cdXZx9259X-7es3u-2-8rxWutLUNYwzwxqiNHGNJ4oKBVwY0IYToTvV-qapoZFCSS2Zlw64odJzxjhQdoyer7lfXG-nFAaXruzogj3f7m2IGdJgCdOCCyIuF_5s5VMavx4gz3YI2UPfuwjjIVuqDdWKl7v-g2pOpRJMFPr0L3oxHlIs_75WzIha1kWdrMqnMecE3e17KbFLle1SZXtd5YKf3EQemgHaW_qnrAXQFXwLPVz9I8pud-_er6G_AeI8s1I</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Scott, J.</creator><creator>Brichant‐Petitjean, C.</creator><creator>Etain, B.</creator><creator>Henry, C.</creator><creator>Kahn, J.‐P.</creator><creator>Azorin, J.‐M.</creator><creator>Leboyer, M.</creator><creator>Bellivier, F.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0002-3660-6640</orcidid><orcidid>https://orcid.org/0000-0002-7203-8601</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid></search><sort><creationdate>201705</creationdate><title>A re‐examination of antidepressant treatment‐emergent mania in bipolar disorders: evidence of gender differences</title><author>Scott, J. ; Brichant‐Petitjean, C. ; Etain, B. ; Henry, C. ; Kahn, J.‐P. ; Azorin, J.‐M. ; Leboyer, M. ; Bellivier, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4278-81ab34393b0780abc07157e459e894058f7dcbb2eb6576863c6ae4916c4334e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>antidepressant treatment‐emergent mania</topic><topic>Antidepressants</topic><topic>antidepressant‐induced mania</topic><topic>Antidepressive Agents</topic><topic>Antidepressive Agents - adverse effects</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Bipolar Disorder</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - psychology</topic><topic>clinical predictors</topic><topic>depression</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Female</topic><topic>gender</topic><topic>Gender differences</topic><topic>Health risk assessment</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatrics and mental health</topic><topic>Psychopharmacology</topic><topic>Regression Analysis</topic><topic>Sex Characteristics</topic><topic>thyroid disease</topic><topic>treatment‐emergent affective switch</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scott, J.</creatorcontrib><creatorcontrib>Brichant‐Petitjean, C.</creatorcontrib><creatorcontrib>Etain, B.</creatorcontrib><creatorcontrib>Henry, C.</creatorcontrib><creatorcontrib>Kahn, J.‐P.</creatorcontrib><creatorcontrib>Azorin, J.‐M.</creatorcontrib><creatorcontrib>Leboyer, M.</creatorcontrib><creatorcontrib>Bellivier, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott, J.</au><au>Brichant‐Petitjean, C.</au><au>Etain, B.</au><au>Henry, C.</au><au>Kahn, J.‐P.</au><au>Azorin, J.‐M.</au><au>Leboyer, M.</au><au>Bellivier, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A re‐examination of antidepressant treatment‐emergent mania in bipolar disorders: evidence of gender differences</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2017-05</date><risdate>2017</risdate><volume>135</volume><issue>5</issue><spage>479</spage><epage>488</epage><pages>479-488</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><abstract>Objective
To explore the prevalence and clinical profile of males and females who develop antidepressant treatment‐emergent mania (ATEM).
Method
From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM‐ controls (n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases.
Results
Seventy‐five individuals were classified as ATEM+; 87% of ATEM events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and/or substance use disorder [Odds Ratio (OR) 6.37], a history of one or more suicide attempts (OR 4.19) and higher number of depressive episodes per year of illness (OR 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder (OR 3.23), a positive family history of BD I (OR 2.68) and depressive onset polarity (OR 2.01).
Conclusion
Using stringent definitions of ATEM status to reduce the probability of inclusion of false‐positive cases and false‐negative controls, we identified for the first time that the risk profiles for the development of an ATEM differ significantly according to gender.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>28369709</pmid><doi>10.1111/acps.12728</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0002-3660-6640</orcidid><orcidid>https://orcid.org/0000-0002-7203-8601</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid></addata></record> |
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| ispartof | Acta psychiatrica Scandinavica, 2017-05, Vol.135 (5), p.479-488 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult antidepressant treatment‐emergent mania Antidepressants antidepressant‐induced mania Antidepressive Agents Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Bipolar Disorder Bipolar Disorder - drug therapy Bipolar Disorder - psychology clinical predictors depression Diagnostic and Statistical Manual of Mental Disorders Female gender Gender differences Health risk assessment Human health and pathology Humans Life Sciences Male Psychiatric Status Rating Scales Psychiatrics and mental health Psychopharmacology Regression Analysis Sex Characteristics thyroid disease treatment‐emergent affective switch Young Adult |
| title | A re‐examination of antidepressant treatment‐emergent mania in bipolar disorders: evidence of gender differences |
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