Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells

T cell development is orchestrated by transcription factors that regulate the expression of genes initially buried within inaccessible chromatin, but the transcription factors that establish the regulatory landscape of the T cell lineage remain unknown. Profiling chromatin accessibility at eight sta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2018-02, Vol.48 (2), p.243-257.e10
Hauptverfasser:	Johnson, John L., Georgakilas, Georgios, Petrovic, Jelena, Kurachi, Makoto, Cai, Stanley, Harly, Christelle, Pear, Warren S., Bhandoola, Avinash, Wherry, E. John, Vahedi, Golnaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessibility Animals Binding sites Cell fate Cell Lineage Chromatin Chromatin - physiology chromatin accessibility Chromatin Assembly and Disassembly Deoxyribonucleic acid Developmental stages DNA Epigenetics Epigenomics Fibroblasts Fibroblasts - metabolism Gene expression Genes Genomes Hepatocyte nuclear factor 1 Hepatocyte Nuclear Factor 1-alpha - physiology Life Sciences Lineage-determining transcription factor Lymphocytes Lymphocytes T Mice NIH 3T3 Cells nucleosomes Regulatory sequences repressed chromatin reprogramming single-cell epigenomics Stem cells T cell development T cell receptors T Cell Transcription Factor 1 - physiology T-Lymphocytes - physiology TCF-1 Transcription factors Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!