Up-regulation of cytolytic functions of human Vδ2− γδ T lymphocytes through engagement of ILT2 expressed by tumor target cells

In humans, the majority of peripheral blood γδ T cells expresses Vγ9Vδ2 T-cell receptors (TCR) and recognize nonpeptidic phosphorylated antigens. In contrast, most tissue-derived γδ T cells, which are located mainly in spleen and epithelia, preferentially use Vδ1 or Vδ3 chains paired with diverse Vγ...

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Veröffentlicht in:	Blood 2011-03, Vol.117 (10), p.2864-2873
Hauptverfasser:	Harly, Christelle, Peyrat, Marie-Alix, Netzer, Sonia, Déchanet-Merville, Julie, Bonneville, Marc, Scotet, Emmanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Hematologic and hematopoietic diseases Life Sciences Medical sciences
Online-Zugang:	Volltext
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