Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

In melanoma, as well as in other solid tumors, the cells within a given tumor exhibit strong morphological, functional and molecular heterogeneity that might reflect the existence of different cancer cell populations, among which are melanoma-initiating cells (MICs) with ‘stemness’ properties and th...

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Veröffentlicht in:	Oncogene 2011-05, Vol.30 (20), p.2307-2318
Hauptverfasser:	Cheli, Y, Guiliano, S, Botton, T, Rocchi, S, Hofman, V, Hofman, P, Bahadoran, P, Bertolotto, C, Ballotti, R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/767/1424 692/420/755 692/699/67/1813/1634 Animals Apoptosis Biological and medical sciences Cancer Cancer cells Cell Biology Cell cycle Cell differentiation Cell Differentiation - genetics Cell Division Cell Line, Tumor Cell physiology Cell Transdifferentiation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin-dependent kinase inhibitor p27 Cyclin-Dependent Kinase Inhibitor p27 - metabolism Dermatology Fundamental and applied biological sciences. Psychology Gene expression Gene Silencing Genetic aspects Human Genetics Human subjects Humans Internal Medicine Life Sciences Lymph nodes Lymphatic Metastasis Medical sciences Medicine Medicine & Public Health Melanoma Melanoma - metabolism Melanoma - pathology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Metastases Mice Mice, Inbred C57BL Microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism Molecular and cellular biology Molecular biology Molecular modelling Neoplasm Transplantation Neoplastic Stem Cells - pathology Oct-4 protein Oncology original-article Physiological aspects Proteins Risk factors Rodents Skin cancer Skin Neoplasms - metabolism Skin Neoplasms - pathology Solid tumors Stem cells Transcription factors Tumors of the skin and soft tissue. Premalignant lesions
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