Metformin blocks melanoma invasion and metastasis development in AMPK/p53-dependent manner

Metformin was reported to inhibit the proliferation of many cancer cells, including melanoma cells. In this report, we investigated the effect of metformin on melanoma invasion and metastasis development. Using different in vitro approaches, we found that metformin inhibits cell invasion without aff...

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Veröffentlicht in:	Molecular cancer therapeutics 2013-08, Vol.12 (8), p.1605-1615
Hauptverfasser:	Cerezo, Michaël, Tichet, Mélanie, Abbe, Patricia, Ohanna, Mickaël, Lehraiki, Abdelali, Rouaud, Florian, Allegra, Maryline, Giacchero, Damien, Bahadoran, Philippe, Bertolotto, Corine, Tartare-Deckert, Sophie, Ballotti, Robert, Rocchi, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Cancer Cell Line, Tumor Cell Movement - drug effects Disease Models, Animal Enzyme Activation - drug effects Epithelial-Mesenchymal Transition - genetics Female Humans Life Sciences Melanoma - genetics Melanoma - metabolism Melanoma - pathology Metalloendopeptidases - metabolism Metformin - pharmacology Mice Neoplasm Invasiveness Neoplasm Metastasis Tumor Suppressor Protein p53 - metabolism
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