Inhibition of Melanogenesis by the Antidiabetic Metformin

Several reports have demonstrated the inhibitory effect of metformin, a widely used drug in the treatment of type 2 diabetes, on the proliferation of many cancers including melanoma. Recently, it has been shown that metformin is able to modulate the cAMP level in the liver. As cAMP has a crucial rol...

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Veröffentlicht in:	Journal of investigative dermatology 2014-10, Vol.134 (10), p.2589-2597
Hauptverfasser:	Lehraiki, Abdelali, Abbe, Patricia, Cerezo, Michael, Rouaud, Florian, Regazzetti, Claire, Chignon-Sicard, Bérengère, Passeron, Thierry, Bertolotto, Corine, Ballotti, Robert, Rocchi, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy Cancer Cell Line, Tumor Cell Proliferation Cells, Cultured Cyclic AMP - metabolism Dose-Response Relationship, Drug Humans Hypoglycemic Agents - pharmacology In Vitro Techniques Life Sciences Melanins - metabolism Melanocytes - drug effects Melanocytes - metabolism Melanocytes - pathology Melanoma - metabolism Melanoma - pathology Metformin - pharmacology Mice Mice, Inbred C57BL Microphthalmia-Associated Transcription Factor - metabolism Skin - drug effects Skin - metabolism Skin - pathology Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Pigmentation - drug effects Time Factors
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