Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells

Phenotypic plasticity and subsequent generation of intratumoral heterogeneity underly key traits in malignant melanoma such as drug resistance and metastasis. Melanoma plasticity promotes a switch between proliferative and invasive phenotypes characterized by different transcriptional programs of wh...

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Veröffentlicht in:	Oncogene 2019-02, Vol.38 (8), p.1282-1295
Hauptverfasser:	Leclerc, Justine, Garandeau, David, Pandiani, Charlotte, Gaudel, Céline, Bille, Karine, Nottet, Nicolas, Garcia, Virginie, Colosetti, Pascal, Pagnotta, Sophie, Bahadoran, Philippe, Tondeur, Garance, Mograbi, Baharia, Dalle, Stéphane, Caramel, Julie, Levade, Thierry, Ballotti, Robert, Andrieu-Abadie, Nathalie, Bertolotto, Corine
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/51 38 38/109 38/39 38/61 38/89 631/67/1813/1634 631/67/70 96/1 96/63 96/95 Acid Ceramidase - genetics Apoptosis Cancer Cancer metastasis Care and treatment Cell Biology Cell Line, Tumor Cell Proliferation - genetics Ceramidase Development and progression Drug resistance Female Focal Adhesion Kinase 1 - genetics Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Human Genetics Humans Hydrolases Integrins Internal Medicine Life Sciences Lipid metabolism Lipids Male Medicine Medicine & Public Health Melanoma Melanoma - genetics Melanoma - pathology Metabolism Metastases Microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - genetics Neoplasm Invasiveness - genetics Oncology Phenotypes Phenotypic plasticity Proto-Oncogene Proteins B-raf Receptors, Vitronectin - genetics Signal Transduction Skin cancer Transcription
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