Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

BACKGROUND:Spontaneous deep intracerebral hemorrhage (ICH) is a devastating subtype of stroke without specific treatments. It has been thought that smooth muscle cell (SMC) degeneration at the site of arteriolar wall rupture may be sufficient to cause hemorrhage. However, deep ICHs are rare in some...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2020-06, Vol.141 (25), p.2078-2094
Hauptverfasser:	Ratelade, Julien, Klug, Nicholas R., Lombardi, Damiano, Angelim, Monara Kaelle Servulo Cruz, Dabertrand, Fabrice, Domenga-Denier, Valérie, Salman, Rustam Al-Shahi, Smith, Colin, Gerbeau, Jean-Frédéric, Nelson, Mark T., Joutel, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Biomarkers Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - etiology Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - prevention & control Collagen Type IV - genetics Collagen Type IV - metabolism Disease Models, Animal Disease Susceptibility Gene Expression Genotype Human health and pathology Humans Immunohistochemistry Life Sciences Life Sciences & Biomedicine Mice Mice, Knockout Microvessels - metabolism Microvessels - physiopathology Molecular Imaging Muscle, Smooth, Vascular - metabolism Mutation Myocytes, Smooth Muscle - metabolism Neurons and Cognition Peripheral Vascular Disease Receptor, Notch3 - metabolism Retina - metabolism Retina - pathology Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Science & Technology
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