Immunologic and Clinical Effects of Injecting Mature Peptide-Loaded Dendritic Cells by Intralymphatic and Intranodal Routes in Metastatic Melanoma Patients

Purpose: A phase I/II trial was conducted to evaluate clinical and immunologic responses after intralymphatic and intranodal injections of mature dendritic cells. Experimental Design: Fourteen patients with a metastatic melanoma received matured dendritic cells, loaded with Melan-A/MART-1 and/or NA1...

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Veröffentlicht in:	Clinical cancer research 2006-12, Vol.12 (24), p.7380-7388
Hauptverfasser:	LESIMPLE, Thierry, NEIDHARD, Eve-Marie, BIREBENT, Brigitte, PHILIP, Irène, TOUJAS, Louis, CHOKRI, Mohamed, QUILLIEN, Véronique, VIGNARD, Virginie, LEFEUVRE, Claudia, ADAMSKI, Henri, LABARRIERE, Nathalie, CARSIN, André, MONNIER, Delphine, COLLET, Brigitte, CLAPISSON, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibody Formation Antigens, Neoplasm - chemistry Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences Cancer Cancer Vaccines - adverse effects Cancer Vaccines - analysis Cancer Vaccines - therapeutic use clinical trial dendritic cells Dendritic Cells - chemistry Dendritic Cells - transplantation Dermatology Disease-Free Survival Female Humans Immunity, Cellular Immunology Immunotherapy Immunotherapy, Adoptive - adverse effects Immunotherapy, Adoptive - methods Injections, Intralymphatic - methods intralymphatic injection intranodal injection Life Sciences Lymphatic Metastasis - immunology Lymphatic Metastasis - pathology Male MART-1 Antigen Medical sciences melanoma Melanoma - immunology Melanoma - mortality Melanoma - therapy Middle Aged Neoplasm Proteins - chemistry Neoplasm Proteins - immunology Peptides - chemistry Peptides - immunology Pharmacology. Drug treatments Skin Neoplasms - immunology Skin Neoplasms - mortality Skin Neoplasms - therapy Survival Analysis Treatment Outcome Tumors of the skin and soft tissue. Premalignant lesions
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