Evidence that up-regulation of the parotid Na(+)-K(+)-2Cl- cotransporter by hypertonic shrinkage is not duplicated by isotonic shrinkage

The application of Ca2+ mobilizing secretagogues to rat parotid acini results in a significant decrease in cell volume (15-30%) due to isotonic salt loss. It is often assumed that the effects of such an isotonic volume decrease can be mimicked by anisotonic cell shrinkage. We demonstrate that the Na...

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Veröffentlicht in:	Molecular and cellular biochemistry 1997-04, Vol.169 (1-2), p.21-25
Hauptverfasser:	Ferri, C, Evans, R L, Paulais, M, Tanimura, A, Turner, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Chloride - pharmacology Animals Calcium - metabolism Carbachol - pharmacology Carrier Proteins - metabolism Cell Size Cells Cellular Biology Chlorides - metabolism Kinases Life Sciences Membrane Proteins - metabolism Muscarinic Agonists - pharmacology Parotid Gland - cytology Parotid Gland - drug effects Potassium - metabolism Protein Kinase Inhibitors Proteins Rats Rats, Wistar Sodium - metabolism Sodium-Potassium-Chloride Symporters Staurosporine - pharmacology Subcellular Processes Up-Regulation
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