Strong Smooth Muscle Differentiation Is Dependent on Myocardin Gene Amplification in Most Human Retroperitoneal Leiomyosarcomas

Myocardin (MYOCD), a serum response factor (SRF) transcriptional cofactor, is essential for cardiac and smooth muscle development and differentiation. We show here by array-based comparative genomic hybridization, fluorescence in situ hybridization, and expression analysis approaches that MYOCD gene...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-03, Vol.69 (6), p.2269-2278
Hauptverfasser:	PEROT, Gaëlle, DERRE, Josette, COINDRE, Jean-Michel, TIRODE, Franck, LUCCHESI, Carlo, MARIANI, Odette, GIBAULT, Laure, GUIHOU, Louis, TERRIER, Philippe, AURIAS, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biochemistry, Molecular Biology Biological and medical sciences Cancer Cell Differentiation - physiology Cell Line, Tumor Cell Movement - physiology Chromosomes, Human, Pair 17 Dermatology Gene Amplification Gene Expression Regulation, Neoplastic Gene Silencing Genomics Humans Leiomyosarcoma - genetics Leiomyosarcoma - metabolism Leiomyosarcoma - pathology Life Sciences Medical sciences Molecular biology Muscle, Smooth - pathology Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Pharmacology. Drug treatments Retroperitoneal Neoplasms - genetics Retroperitoneal Neoplasms - metabolism Retroperitoneal Neoplasms - pathology RNA, Small Interfering - genetics Trans-Activators - antagonists & inhibitors Trans-Activators - biosynthesis Trans-Activators - genetics Tumors Tumors of the skin and soft tissue. Premalignant lesions Up-Regulation
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