Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I

Abasic sites and deamination of cytosine to uracil are probably the most common types of endogenous DNA damage. The effects of such lesions on DNA topoisomerase I (top1) activity were examined in oligonucleotides containing a unique top1 cleavage site. The presence of uracils and abasic sites within...

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Veröffentlicht in:	The Journal of biological chemistry 1997-03, Vol.272 (12), p.7792-7796
Hauptverfasser:	Pourquier, Philippe, Ueng, Li-Ming, Kohlhagen, Glenda, Mazumder, Abhijit, Gupta, Malini, Kohn, Kurt W., Pommier, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites DNA - genetics DNA Topoisomerases, Type I - metabolism Hydrolysis Life Sciences Mammals Nucleic Acid Heteroduplexes Uracil - metabolism
Online-Zugang:	Volltext
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