Structural Analysis of the Human Rad51 Protein-DNA Complex Filament by Tryptophan Fluorescence Scanning Analysis: Transmission of Allosteric Effects between ATP Binding and DNA Binding

Human Rad51 (HsRad51) catalyzes the strand exchange reaction, a crucial step in homologous recombination, by forming a filamentous complex with DNA. The structure of this filament is modified by ATP, which is required and hydrolyzed for the reaction. We analyzed the structure and the ATP-promoted co...

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Veröffentlicht in:	Journal of molecular biology 2008, Vol.383, p.575-587
Hauptverfasser:	Renodon-Cornière, Axelle, Takizawa, Yoshimasa, Conilleau, Sébastien, Tran, Vinh, Iwai, Shigenori, Kurumizaka, Hitoshi, Takahashi, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Life Sciences
Online-Zugang:	Volltext
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