Post-Translational Regulation of the Glucose-6-Phosphatase Complex by Cyclic Adenosine Monophosphate Is a Crucial Determinant of Endogenous Glucose Production and Is Controlled by the Glucose-6-Phosphate Transporter

The excessive endogenous glucose production (EGP) induced by glucagon participates in the development of type 2 diabetes. To further understand this hormonal control, we studied the short-term regulation by cyclic adenosine monophosphate (cAMP) of the glucose-6-phosphatase (G6Pase) enzyme, which cat...

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Veröffentlicht in:	Journal of proteome research 2016-04, Vol.15 (4), p.1342-1349
Hauptverfasser:	Soty, Maud, Chilloux, Julien, Delalande, François, Zitoun, Carine, Bertile, Fabrice, Mithieux, Gilles, Gautier-Stein, Amandine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - genetics Adenoviruses, Human - metabolism Animals Antiporters - genetics Antiporters - metabolism Caco-2 Cells Cell Line Colforsin - pharmacology Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation Genetic Vectors - chemistry Genetic Vectors - metabolism Glucagon - pharmacology Glucose - biosynthesis Glucose-6-Phosphatase - genetics Glucose-6-Phosphatase - metabolism Glucose-6-Phosphate - metabolism Hep G2 Cells Humans Life Sciences Monosaccharide Transport Proteins - genetics Monosaccharide Transport Proteins - metabolism Mutagenesis, Site-Directed Neurons and Cognition Phosphorylation Protein Biosynthesis Protein Subunits - genetics Protein Subunits - metabolism Rats Signal Transduction
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