A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis

Objective The two related tumor necrosis factor members a proliferation‐inducing ligand (APRIL) and B‐cell activation factor (BAFF) are currently targeted in autoimmune diseases as B‐cell regulators. In multiple sclerosis (MS), combined APRIL/BAFF blockade led to unexpected exacerbated inflammation...

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Veröffentlicht in:	Annals of neurology 2019-03, Vol.85 (3), p.406-420
Hauptverfasser:	Baert, Laurie, Benkhoucha, Mahdia, Popa, Natalia, Ahmed, Mashal C., Manfroi, Benoit, Boutonnat, Jean, Sturm, Nathalie, Raguenez, Gilda, Tessier, Marine, Casez, Olivier, Marignier, Romain, Ahmadi, Mitra, Broisat, Alexis, Ghezzi, Catherine, Rivat, Cyril, Sonrier, Corinne, Hahne, Michael, Baeten, Dominique, Vives, Romain R., Lortat‐Jacob, Hugues, Marche, Patrice N., Schneider, Pascal, Lassmann, Hans P., Boucraut, Jose, Lalive, Patrice H., Huard, Bertrand
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals APRIL protein Astrocytes Astrocytes - immunology Astrocytes - metabolism Astrocytes - pathology Autoimmune diseases B-Cell Activating Factor - metabolism Biochemistry, Molecular Biology BLyS protein Cell activation Cell Proliferation Central nervous system Chondroitin sulfate Chondroitin Sulfate Proteoglycans - metabolism Chondroitin Sulfates - metabolism Cytokines - immunology Disease Disease Models, Animal Encephalitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Female Human performance Humans Immunohistochemistry Immunology Infiltration Inflammation Inflammatory response Interleukin-10 - immunology Intravenous administration Lesions Life Sciences Ligands Lymphocytes B Macrophages Macrophages - pathology Male Metastases Mice Mice, Knockout Middle Aged Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Patients Proteoglycans Regulators Reverse Transcriptase Polymerase Chain Reaction Selectivity Signs and symptoms Sugar Sulfates T-Lymphocytes - immunology Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism Tumor Necrosis Factor Ligand Superfamily Member 13 - pharmacology
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