Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness

TLR repertoire and in vitro responsiveness of blood classical DC subsets. Human blood DCs encompass pDCs and two subsets of mDCs: CD1c+ mDCs and CD141+ mDCs. The rare CD141+ DC population is thought to be the equivalent of mouse CD8α+ cDCs that play a significant role in antigen cross‐presentation....

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Veröffentlicht in:	Journal of leukocyte biology 2013-04, Vol.93 (4), p.599-609
Hauptverfasser:	Hémont, Caroline, Neel, Antoine, Heslan, Michèle, Braudeau, Cécile, Josien, Régis
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation Antigens, CD - genetics Antigens, CD - immunology Antigens, CD1 - genetics Antigens, CD1 - immunology CD141 Cells, Cultured cytokines Cytokines - immunology Cytokines - secretion dendritic cells Dendritic Cells - classification Dendritic Cells - cytology Dendritic Cells - immunology Flow Cytometry Glycoproteins - genetics Glycoproteins - immunology Human health and pathology Humans Immunomagnetic Separation Immunophenotyping Life Sciences Protein Isoforms - classification Protein Isoforms - genetics Protein Isoforms - immunology Toll-Like Receptors - classification Toll-Like Receptors - genetics Toll-Like Receptors - immunology Toll‐like receptors
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